| Full name: PNKD metallo-beta-lactamase domain containing | Alias Symbol: DYT8|PDC|DKFZp564N1362|FPD1|MR-1|BRP17|FKSG19|TAHCCP2|KIAA1184|KIPP1184|MGC31943|PKND1|MR-1S | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 25953 | HGNC ID: HGNC:9153 | Ensembl Gene: ENSG00000127838 | OMIM ID: 609023 |
| Drug and gene relationship at DGIdb | |||
Expression of PNKD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNKD | 25953 | 225298_at | -0.2834 | 0.5785 | |
| GSE26886 | PNKD | 25953 | 225298_at | 0.3567 | 0.0584 | |
| GSE45670 | PNKD | 25953 | 225298_at | -0.3854 | 0.0111 | |
| GSE53622 | PNKD | 25953 | 28662 | -0.1607 | 0.0837 | |
| GSE53624 | PNKD | 25953 | 28662 | 0.0097 | 0.9271 | |
| GSE63941 | PNKD | 25953 | 225298_at | -0.4656 | 0.4803 | |
| GSE77861 | PNKD | 25953 | 225298_at | -0.0704 | 0.7801 | |
| GSE97050 | PNKD | 25953 | A_23_P90732 | -0.2092 | 0.4963 | |
| SRP007169 | PNKD | 25953 | RNAseq | -0.1485 | 0.7144 | |
| SRP008496 | PNKD | 25953 | RNAseq | -0.1905 | 0.4184 | |
| SRP064894 | PNKD | 25953 | RNAseq | 0.1027 | 0.7636 | |
| SRP133303 | PNKD | 25953 | RNAseq | -0.1490 | 0.2368 | |
| SRP159526 | PNKD | 25953 | RNAseq | 0.1827 | 0.3634 | |
| SRP193095 | PNKD | 25953 | RNAseq | -0.2911 | 0.0211 | |
| SRP219564 | PNKD | 25953 | RNAseq | -0.2816 | 0.5499 | |
| TCGA | PNKD | 25953 | RNAseq | -0.2930 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PNKD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNKD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNKD | 25953 | 1 | 14 | 15 | |
| GSE20123 | PNKD | 25953 | 1 | 13 | 16 | |
| GSE43470 | PNKD | 25953 | 1 | 7 | 35 | |
| GSE46452 | PNKD | 25953 | 0 | 5 | 54 | |
| GSE47630 | PNKD | 25953 | 4 | 5 | 31 | |
| GSE54993 | PNKD | 25953 | 1 | 2 | 67 | |
| GSE54994 | PNKD | 25953 | 8 | 10 | 35 | |
| GSE60625 | PNKD | 25953 | 0 | 3 | 8 | |
| GSE74703 | PNKD | 25953 | 1 | 5 | 30 | |
| GSE74704 | PNKD | 25953 | 1 | 7 | 12 | |
| TCGA | PNKD | 25953 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 100; Total Number of normals: 359.
Somatic mutations of PNKD:
Generating mutation plots.
Highly correlated genes for PNKD:
Showing top 20/296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNKD | MKLN1 | 0.825314 | 3 | 0 | 3 |
| PNKD | ICA1L | 0.797184 | 3 | 0 | 3 |
| PNKD | PNN | 0.785719 | 3 | 0 | 3 |
| PNKD | CDC26 | 0.785259 | 3 | 0 | 3 |
| PNKD | BRAP | 0.780792 | 3 | 0 | 3 |
| PNKD | SRI | 0.778132 | 3 | 0 | 3 |
| PNKD | SPRYD3 | 0.773383 | 3 | 0 | 3 |
| PNKD | FAM122B | 0.771444 | 3 | 0 | 3 |
| PNKD | RRAGB | 0.764273 | 3 | 0 | 3 |
| PNKD | ZNF510 | 0.754669 | 3 | 0 | 3 |
| PNKD | MIF4GD | 0.751711 | 3 | 0 | 3 |
| PNKD | EPS8 | 0.738327 | 3 | 0 | 3 |
| PNKD | ALDH1A1 | 0.732062 | 3 | 0 | 3 |
| PNKD | DOCK7 | 0.731907 | 3 | 0 | 3 |
| PNKD | SENP8 | 0.730547 | 4 | 0 | 3 |
| PNKD | TRAK1 | 0.726662 | 3 | 0 | 3 |
| PNKD | PRKAG2 | 0.726293 | 3 | 0 | 3 |
| PNKD | STXBP4 | 0.726135 | 3 | 0 | 3 |
| PNKD | UXT | 0.725618 | 4 | 0 | 4 |
| PNKD | STX10 | 0.722046 | 3 | 0 | 3 |
For details and further investigation, click here
