| Full name: aldehyde dehydrogenase 8 family member A1 | Alias Symbol: ALDH12 | ||
| Type: protein-coding gene | Cytoband: 6q23.3 | ||
| Entrez ID: 64577 | HGNC ID: HGNC:15471 | Ensembl Gene: ENSG00000118514 | OMIM ID: 606467 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH8A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH8A1 | 64577 | 220148_at | -0.5368 | 0.4053 | |
| GSE20347 | ALDH8A1 | 64577 | 220148_at | 0.1539 | 0.2923 | |
| GSE23400 | ALDH8A1 | 64577 | 220148_at | -0.0638 | 0.1228 | |
| GSE26886 | ALDH8A1 | 64577 | 220148_at | 0.8983 | 0.0168 | |
| GSE29001 | ALDH8A1 | 64577 | 220148_at | -0.0197 | 0.9730 | |
| GSE38129 | ALDH8A1 | 64577 | 220148_at | 0.1996 | 0.5629 | |
| GSE45670 | ALDH8A1 | 64577 | 220148_at | -0.0066 | 0.9950 | |
| GSE53622 | ALDH8A1 | 64577 | 66778 | 0.0186 | 0.8720 | |
| GSE53624 | ALDH8A1 | 64577 | 66778 | 0.1844 | 0.0980 | |
| GSE63941 | ALDH8A1 | 64577 | 220148_at | -1.1994 | 0.0000 | |
| GSE77861 | ALDH8A1 | 64577 | 220148_at | 0.5305 | 0.4412 | |
| GSE97050 | ALDH8A1 | 64577 | A_24_P283324 | -0.2329 | 0.4284 | |
| SRP007169 | ALDH8A1 | 64577 | RNAseq | -1.2390 | 0.0441 | |
| SRP008496 | ALDH8A1 | 64577 | RNAseq | -0.9967 | 0.0104 | |
| SRP064894 | ALDH8A1 | 64577 | RNAseq | -0.0927 | 0.7421 | |
| SRP133303 | ALDH8A1 | 64577 | RNAseq | -0.2511 | 0.2283 | |
| SRP159526 | ALDH8A1 | 64577 | RNAseq | 0.8556 | 0.1100 | |
| SRP219564 | ALDH8A1 | 64577 | RNAseq | -0.4712 | 0.5883 | |
| TCGA | ALDH8A1 | 64577 | RNAseq | -0.4702 | 0.2285 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ALDH8A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH8A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH8A1 | 64577 | 5 | 4 | 21 | |
| GSE20123 | ALDH8A1 | 64577 | 5 | 3 | 22 | |
| GSE43470 | ALDH8A1 | 64577 | 5 | 0 | 38 | |
| GSE46452 | ALDH8A1 | 64577 | 3 | 10 | 46 | |
| GSE47630 | ALDH8A1 | 64577 | 10 | 4 | 26 | |
| GSE54993 | ALDH8A1 | 64577 | 3 | 2 | 65 | |
| GSE54994 | ALDH8A1 | 64577 | 9 | 7 | 37 | |
| GSE60625 | ALDH8A1 | 64577 | 0 | 1 | 10 | |
| GSE74703 | ALDH8A1 | 64577 | 4 | 0 | 32 | |
| GSE74704 | ALDH8A1 | 64577 | 2 | 1 | 17 | |
| TCGA | ALDH8A1 | 64577 | 12 | 18 | 66 |
Total number of gains: 58; Total number of losses: 50; Total Number of normals: 380.
Somatic mutations of ALDH8A1:
Generating mutation plots.
Highly correlated genes for ALDH8A1:
Showing top 20/87 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH8A1 | LDB2 | 0.771849 | 3 | 0 | 3 |
| ALDH8A1 | RASSF1 | 0.750835 | 3 | 0 | 3 |
| ALDH8A1 | SHISA3 | 0.75017 | 3 | 0 | 3 |
| ALDH8A1 | NRXN1 | 0.749594 | 3 | 0 | 3 |
| ALDH8A1 | OR2D2 | 0.741609 | 3 | 0 | 3 |
| ALDH8A1 | TCEAL7 | 0.733875 | 3 | 0 | 3 |
| ALDH8A1 | JAZF1-AS1 | 0.729368 | 3 | 0 | 3 |
| ALDH8A1 | CCL27 | 0.72884 | 3 | 0 | 3 |
| ALDH8A1 | DLK1 | 0.724334 | 3 | 0 | 3 |
| ALDH8A1 | OR56A5 | 0.721919 | 3 | 0 | 3 |
| ALDH8A1 | OR2B11 | 0.718307 | 3 | 0 | 3 |
| ALDH8A1 | PRODH2 | 0.714585 | 3 | 0 | 3 |
| ALDH8A1 | CDC42EP2 | 0.712978 | 4 | 0 | 3 |
| ALDH8A1 | PRDM6 | 0.708462 | 3 | 0 | 3 |
| ALDH8A1 | GOLGA6L6 | 0.704628 | 3 | 0 | 3 |
| ALDH8A1 | NPR2 | 0.701689 | 5 | 0 | 4 |
| ALDH8A1 | CNTN4 | 0.69963 | 3 | 0 | 3 |
| ALDH8A1 | FREM1 | 0.698091 | 3 | 0 | 3 |
| ALDH8A1 | ZCCHC18 | 0.696672 | 4 | 0 | 4 |
| ALDH8A1 | RASSF8-AS1 | 0.694143 | 3 | 0 | 3 |
For details and further investigation, click here
