| Full name: Ras association domain family member 1 | Alias Symbol: NORE2A|REH3P21|RDA32|123F2 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 11186 | HGNC ID: HGNC:9882 | Ensembl Gene: ENSG00000068028 | OMIM ID: 605082 |
| Drug and gene relationship at DGIdb | |||
RASSF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04390 | Hippo signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05219 | Bladder cancer | |
| hsa05223 | Non-small cell lung cancer |
Expression of RASSF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASSF1 | 11186 | 204346_s_at | -0.1914 | 0.6524 | |
| GSE20347 | RASSF1 | 11186 | 204346_s_at | -0.2039 | 0.0903 | |
| GSE23400 | RASSF1 | 11186 | 204346_s_at | -0.1022 | 0.0485 | |
| GSE26886 | RASSF1 | 11186 | 204346_s_at | -0.3435 | 0.1109 | |
| GSE29001 | RASSF1 | 11186 | 204346_s_at | -0.0655 | 0.6722 | |
| GSE38129 | RASSF1 | 11186 | 204346_s_at | -0.3254 | 0.0469 | |
| GSE45670 | RASSF1 | 11186 | 204346_s_at | -0.2085 | 0.0271 | |
| GSE53622 | RASSF1 | 11186 | 47742 | -0.4346 | 0.0000 | |
| GSE53624 | RASSF1 | 11186 | 47742 | -0.1682 | 0.0007 | |
| GSE63941 | RASSF1 | 11186 | 204346_s_at | -1.9155 | 0.0011 | |
| GSE77861 | RASSF1 | 11186 | 204346_s_at | -0.0941 | 0.6530 | |
| GSE97050 | RASSF1 | 11186 | A_33_P3316934 | 0.1757 | 0.4712 | |
| SRP007169 | RASSF1 | 11186 | RNAseq | -0.1421 | 0.7540 | |
| SRP008496 | RASSF1 | 11186 | RNAseq | -0.1016 | 0.7302 | |
| SRP064894 | RASSF1 | 11186 | RNAseq | 0.3509 | 0.1030 | |
| SRP133303 | RASSF1 | 11186 | RNAseq | -0.3437 | 0.0129 | |
| SRP159526 | RASSF1 | 11186 | RNAseq | -0.6251 | 0.0000 | |
| SRP193095 | RASSF1 | 11186 | RNAseq | -0.1075 | 0.4147 | |
| SRP219564 | RASSF1 | 11186 | RNAseq | -0.2869 | 0.3980 | |
| TCGA | RASSF1 | 11186 | RNAseq | -0.2413 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RASSF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASSF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASSF1 | 11186 | 0 | 18 | 12 | |
| GSE20123 | RASSF1 | 11186 | 0 | 19 | 11 | |
| GSE43470 | RASSF1 | 11186 | 0 | 19 | 24 | |
| GSE46452 | RASSF1 | 11186 | 2 | 16 | 41 | |
| GSE47630 | RASSF1 | 11186 | 1 | 24 | 15 | |
| GSE54993 | RASSF1 | 11186 | 6 | 2 | 62 | |
| GSE54994 | RASSF1 | 11186 | 0 | 34 | 19 | |
| GSE60625 | RASSF1 | 11186 | 5 | 0 | 6 | |
| GSE74703 | RASSF1 | 11186 | 0 | 15 | 21 | |
| GSE74704 | RASSF1 | 11186 | 0 | 12 | 8 | |
| TCGA | RASSF1 | 11186 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of RASSF1:
Generating mutation plots.
Highly correlated genes for RASSF1:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASSF1 | ALDH8A1 | 0.750835 | 3 | 0 | 3 |
| RASSF1 | DCN | 0.712142 | 3 | 0 | 3 |
| RASSF1 | TNFSF13B | 0.71107 | 3 | 0 | 3 |
| RASSF1 | FSIP1 | 0.707667 | 3 | 0 | 3 |
| RASSF1 | NAV3 | 0.688124 | 3 | 0 | 3 |
| RASSF1 | RASGRF2 | 0.684035 | 3 | 0 | 3 |
| RASSF1 | ENTPD1 | 0.683706 | 4 | 0 | 4 |
| RASSF1 | GPR88 | 0.66988 | 4 | 0 | 4 |
| RASSF1 | MOB1B | 0.668061 | 3 | 0 | 3 |
| RASSF1 | MYO1C | 0.663438 | 4 | 0 | 3 |
| RASSF1 | NPR2 | 0.663336 | 5 | 0 | 4 |
| RASSF1 | BICC1 | 0.661386 | 3 | 0 | 3 |
| RASSF1 | POLR3G | 0.660911 | 3 | 0 | 3 |
| RASSF1 | GINM1 | 0.660073 | 3 | 0 | 3 |
| RASSF1 | SIGIRR | 0.659639 | 3 | 0 | 3 |
| RASSF1 | WDFY3-AS2 | 0.650745 | 3 | 0 | 3 |
| RASSF1 | ACE | 0.646028 | 3 | 0 | 3 |
| RASSF1 | LINC-PINT | 0.639724 | 3 | 0 | 3 |
| RASSF1 | TBX5-AS1 | 0.630029 | 3 | 0 | 3 |
| RASSF1 | HDC | 0.627649 | 4 | 0 | 3 |
For details and further investigation, click here
