| Full name: natriuretic peptide receptor 2 | Alias Symbol: GUCY2B|ANPb | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 4882 | HGNC ID: HGNC:7944 | Ensembl Gene: ENSG00000159899 | OMIM ID: 108961 |
| Drug and gene relationship at DGIdb | |||
NPR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction | |
| hsa04921 | Oxytocin signaling pathway |
Expression of NPR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPR2 | 4882 | 204310_s_at | -0.4354 | 0.4305 | |
| GSE20347 | NPR2 | 4882 | 204310_s_at | -0.0642 | 0.4728 | |
| GSE23400 | NPR2 | 4882 | 214066_x_at | -0.0036 | 0.9046 | |
| GSE26886 | NPR2 | 4882 | 214066_x_at | 0.0772 | 0.6601 | |
| GSE29001 | NPR2 | 4882 | 214066_x_at | 0.0808 | 0.7012 | |
| GSE38129 | NPR2 | 4882 | 204310_s_at | -0.3595 | 0.0595 | |
| GSE45670 | NPR2 | 4882 | 204310_s_at | -0.6588 | 0.0035 | |
| GSE53622 | NPR2 | 4882 | 64071 | -0.0987 | 0.3526 | |
| GSE53624 | NPR2 | 4882 | 64071 | -0.0203 | 0.8291 | |
| GSE63941 | NPR2 | 4882 | 204310_s_at | -2.3925 | 0.0001 | |
| GSE77861 | NPR2 | 4882 | 204310_s_at | -0.0290 | 0.8550 | |
| GSE97050 | NPR2 | 4882 | A_23_P123622 | -0.2993 | 0.2813 | |
| SRP064894 | NPR2 | 4882 | RNAseq | 0.1746 | 0.4865 | |
| SRP133303 | NPR2 | 4882 | RNAseq | -0.1176 | 0.7369 | |
| SRP159526 | NPR2 | 4882 | RNAseq | 0.3844 | 0.3334 | |
| SRP193095 | NPR2 | 4882 | RNAseq | 1.4349 | 0.0001 | |
| SRP219564 | NPR2 | 4882 | RNAseq | -0.2326 | 0.7394 | |
| TCGA | NPR2 | 4882 | RNAseq | -0.2645 | 0.2131 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by NPR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPR2 | 4882 | 3 | 12 | 15 | |
| GSE20123 | NPR2 | 4882 | 3 | 12 | 15 | |
| GSE43470 | NPR2 | 4882 | 3 | 10 | 30 | |
| GSE46452 | NPR2 | 4882 | 6 | 15 | 38 | |
| GSE47630 | NPR2 | 4882 | 1 | 20 | 19 | |
| GSE54993 | NPR2 | 4882 | 6 | 0 | 64 | |
| GSE54994 | NPR2 | 4882 | 5 | 12 | 36 | |
| GSE60625 | NPR2 | 4882 | 0 | 0 | 11 | |
| GSE74703 | NPR2 | 4882 | 2 | 7 | 27 | |
| GSE74704 | NPR2 | 4882 | 0 | 10 | 10 | |
| TCGA | NPR2 | 4882 | 17 | 44 | 35 |
Total number of gains: 46; Total number of losses: 142; Total Number of normals: 300.
Somatic mutations of NPR2:
Generating mutation plots.
Highly correlated genes for NPR2:
Showing top 20/277 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPR2 | HRC | 0.809023 | 3 | 0 | 3 |
| NPR2 | ADAMTS19 | 0.800375 | 3 | 0 | 3 |
| NPR2 | SPTBN4 | 0.788753 | 3 | 0 | 3 |
| NPR2 | PDZRN3 | 0.7833 | 4 | 0 | 4 |
| NPR2 | NRXN1 | 0.765787 | 6 | 0 | 6 |
| NPR2 | PGM5-AS1 | 0.755203 | 3 | 0 | 3 |
| NPR2 | RBM24 | 0.729381 | 4 | 0 | 3 |
| NPR2 | TMEM59L | 0.729167 | 3 | 0 | 3 |
| NPR2 | LENG1 | 0.724299 | 3 | 0 | 3 |
| NPR2 | ANKDD1A | 0.722834 | 4 | 0 | 4 |
| NPR2 | TNXB | 0.712859 | 3 | 0 | 3 |
| NPR2 | MEG3 | 0.709541 | 4 | 0 | 4 |
| NPR2 | ALDH8A1 | 0.701689 | 5 | 0 | 4 |
| NPR2 | NICN1 | 0.701319 | 3 | 0 | 3 |
| NPR2 | GRIN1 | 0.697275 | 4 | 0 | 3 |
| NPR2 | PKDCC | 0.696438 | 5 | 0 | 4 |
| NPR2 | INSC | 0.695753 | 4 | 0 | 3 |
| NPR2 | FBLN7 | 0.694484 | 3 | 0 | 3 |
| NPR2 | SIGLEC11 | 0.69123 | 3 | 0 | 3 |
| NPR2 | PEG3-AS1 | 0.689079 | 3 | 0 | 3 |
For details and further investigation, click here
