| Full name: neurexin 1 | Alias Symbol: KIAA0578|Hs.22998 | ||
| Type: protein-coding gene | Cytoband: 2p16.3 | ||
| Entrez ID: 9378 | HGNC ID: HGNC:8008 | Ensembl Gene: ENSG00000179915 | OMIM ID: 600565 |
| Drug and gene relationship at DGIdb | |||
Expression of NRXN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRXN1 | 9378 | 209914_s_at | -0.8146 | 0.4482 | |
| GSE20347 | NRXN1 | 9378 | 209914_s_at | -0.1118 | 0.0974 | |
| GSE23400 | NRXN1 | 9378 | 209915_s_at | -0.0300 | 0.5497 | |
| GSE26886 | NRXN1 | 9378 | 209914_s_at | 0.4539 | 0.0122 | |
| GSE29001 | NRXN1 | 9378 | 209914_s_at | 0.0212 | 0.9571 | |
| GSE38129 | NRXN1 | 9378 | 209914_s_at | -0.5679 | 0.0053 | |
| GSE45670 | NRXN1 | 9378 | 209914_s_at | -0.9005 | 0.0450 | |
| GSE53622 | NRXN1 | 9378 | 61317 | 0.3740 | 0.1164 | |
| GSE53624 | NRXN1 | 9378 | 89201 | -1.9147 | 0.0000 | |
| GSE63941 | NRXN1 | 9378 | 209914_s_at | 0.1577 | 0.3938 | |
| GSE77861 | NRXN1 | 9378 | 237535_x_at | -0.0521 | 0.7554 | |
| GSE97050 | NRXN1 | 9378 | A_33_P3273679 | -0.2018 | 0.8338 | |
| SRP064894 | NRXN1 | 9378 | RNAseq | -0.0130 | 0.9813 | |
| SRP133303 | NRXN1 | 9378 | RNAseq | -0.9665 | 0.0527 | |
| SRP159526 | NRXN1 | 9378 | RNAseq | 0.3150 | 0.7021 | |
| SRP219564 | NRXN1 | 9378 | RNAseq | -0.6565 | 0.5862 | |
| TCGA | NRXN1 | 9378 | RNAseq | -1.6266 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NRXN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NRXN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRXN1 | 9378 | 5 | 2 | 23 | |
| GSE20123 | NRXN1 | 9378 | 4 | 2 | 24 | |
| GSE43470 | NRXN1 | 9378 | 5 | 0 | 38 | |
| GSE46452 | NRXN1 | 9378 | 1 | 4 | 54 | |
| GSE47630 | NRXN1 | 9378 | 8 | 0 | 32 | |
| GSE54993 | NRXN1 | 9378 | 0 | 5 | 65 | |
| GSE54994 | NRXN1 | 9378 | 12 | 0 | 41 | |
| GSE60625 | NRXN1 | 9378 | 0 | 3 | 8 | |
| GSE74703 | NRXN1 | 9378 | 5 | 0 | 31 | |
| GSE74704 | NRXN1 | 9378 | 5 | 2 | 13 | |
| TCGA | NRXN1 | 9378 | 36 | 2 | 58 |
Total number of gains: 81; Total number of losses: 20; Total Number of normals: 387.
Somatic mutations of NRXN1:
Generating mutation plots.
Highly correlated genes for NRXN1:
Showing top 20/276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRXN1 | NPR2 | 0.765787 | 6 | 0 | 6 |
| NRXN1 | FAM71F1 | 0.754834 | 3 | 0 | 3 |
| NRXN1 | GDNF | 0.753739 | 3 | 0 | 3 |
| NRXN1 | TEF | 0.753322 | 3 | 0 | 3 |
| NRXN1 | ALDH8A1 | 0.749594 | 3 | 0 | 3 |
| NRXN1 | PRDM6 | 0.725656 | 3 | 0 | 3 |
| NRXN1 | TRPM8 | 0.724984 | 3 | 0 | 3 |
| NRXN1 | ZNF575 | 0.718589 | 3 | 0 | 3 |
| NRXN1 | SHISA4 | 0.716974 | 3 | 0 | 3 |
| NRXN1 | PNMA3 | 0.707373 | 3 | 0 | 3 |
| NRXN1 | HRC | 0.702664 | 4 | 0 | 3 |
| NRXN1 | IGLON5 | 0.69637 | 3 | 0 | 3 |
| NRXN1 | HAAO | 0.69154 | 3 | 0 | 3 |
| NRXN1 | ADAMTS7 | 0.685814 | 3 | 0 | 3 |
| NRXN1 | THRSP | 0.683514 | 3 | 0 | 3 |
| NRXN1 | CADPS | 0.683137 | 4 | 0 | 4 |
| NRXN1 | CCDC181 | 0.680991 | 6 | 0 | 6 |
| NRXN1 | CDC42EP2 | 0.678555 | 5 | 0 | 3 |
| NRXN1 | ATP7B | 0.678203 | 5 | 0 | 5 |
| NRXN1 | GABRA5 | 0.674479 | 5 | 0 | 4 |
For details and further investigation, click here
