| Full name: leukocyte receptor cluster member 8 | Alias Symbol: KIAA1932|MGC40108|pp13842 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 114823 | HGNC ID: HGNC:15500 | Ensembl Gene: ENSG00000167615 | OMIM ID: 616575 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LENG8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LENG8 | 114823 | 224673_at | 0.2147 | 0.8455 | |
| GSE26886 | LENG8 | 114823 | 224673_at | 0.4918 | 0.0172 | |
| GSE45670 | LENG8 | 114823 | 224673_at | -0.1376 | 0.3744 | |
| GSE53622 | LENG8 | 114823 | 70688 | -0.1318 | 0.0215 | |
| GSE53624 | LENG8 | 114823 | 70688 | -0.2232 | 0.0022 | |
| GSE63941 | LENG8 | 114823 | 224673_at | 0.3647 | 0.3645 | |
| GSE77861 | LENG8 | 114823 | 224673_at | 0.3246 | 0.2177 | |
| GSE97050 | LENG8 | 114823 | A_33_P3280687 | -0.3071 | 0.1937 | |
| SRP007169 | LENG8 | 114823 | RNAseq | -0.2996 | 0.3874 | |
| SRP008496 | LENG8 | 114823 | RNAseq | -0.1516 | 0.5318 | |
| SRP064894 | LENG8 | 114823 | RNAseq | -0.1489 | 0.5397 | |
| SRP133303 | LENG8 | 114823 | RNAseq | -0.2348 | 0.2253 | |
| SRP159526 | LENG8 | 114823 | RNAseq | -0.2977 | 0.2379 | |
| SRP193095 | LENG8 | 114823 | RNAseq | 0.1374 | 0.3607 | |
| SRP219564 | LENG8 | 114823 | RNAseq | -0.1224 | 0.6357 | |
| TCGA | LENG8 | 114823 | RNAseq | -0.1678 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LENG8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LENG8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LENG8 | 114823 | 3 | 4 | 23 | |
| GSE20123 | LENG8 | 114823 | 3 | 3 | 24 | |
| GSE43470 | LENG8 | 114823 | 2 | 11 | 30 | |
| GSE46452 | LENG8 | 114823 | 45 | 1 | 13 | |
| GSE47630 | LENG8 | 114823 | 8 | 6 | 26 | |
| GSE54993 | LENG8 | 114823 | 17 | 4 | 49 | |
| GSE54994 | LENG8 | 114823 | 4 | 13 | 36 | |
| GSE60625 | LENG8 | 114823 | 9 | 0 | 2 | |
| GSE74703 | LENG8 | 114823 | 2 | 7 | 27 | |
| GSE74704 | LENG8 | 114823 | 3 | 1 | 16 | |
| TCGA | LENG8 | 114823 | 19 | 14 | 63 |
Total number of gains: 115; Total number of losses: 64; Total Number of normals: 309.
Somatic mutations of LENG8:
Generating mutation plots.
Highly correlated genes for LENG8:
Showing top 20/289 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LENG8 | FUBP1 | 0.785382 | 3 | 0 | 3 |
| LENG8 | NFIC | 0.7771 | 3 | 0 | 3 |
| LENG8 | NCKIPSD | 0.775923 | 3 | 0 | 3 |
| LENG8 | SUGP1 | 0.775877 | 3 | 0 | 3 |
| LENG8 | ZNF417 | 0.763855 | 3 | 0 | 3 |
| LENG8 | GSK3A | 0.762798 | 4 | 0 | 3 |
| LENG8 | ZNF358 | 0.76136 | 3 | 0 | 3 |
| LENG8 | TESK1 | 0.755208 | 3 | 0 | 3 |
| LENG8 | MAN1B1 | 0.754582 | 3 | 0 | 3 |
| LENG8 | CPLX1 | 0.751887 | 3 | 0 | 3 |
| LENG8 | CTF1 | 0.742685 | 3 | 0 | 3 |
| LENG8 | NRL | 0.742444 | 3 | 0 | 3 |
| LENG8 | TBC1D25 | 0.740049 | 3 | 0 | 3 |
| LENG8 | ARF1 | 0.73786 | 4 | 0 | 4 |
| LENG8 | CABIN1 | 0.735181 | 4 | 0 | 4 |
| LENG8 | RHOBTB2 | 0.732963 | 3 | 0 | 3 |
| LENG8 | G0S2 | 0.732689 | 3 | 0 | 3 |
| LENG8 | RPL38 | 0.730524 | 3 | 0 | 3 |
| LENG8 | SF1 | 0.727902 | 3 | 0 | 3 |
| LENG8 | FIP1L1 | 0.726441 | 3 | 0 | 3 |
For details and further investigation, click here
