| Full name: adaptor related protein complex 2 subunit alpha 2 | Alias Symbol: DKFZP564D1864|HYPJ|KIAA0899|HIP9 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 161 | HGNC ID: HGNC:562 | Ensembl Gene: ENSG00000183020 | OMIM ID: 607242 |
| Drug and gene relationship at DGIdb | |||
AP2A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05016 | Huntington's disease |
Expression of AP2A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AP2A2 | 161 | 212159_x_at | -0.1347 | 0.5413 | |
| GSE20347 | AP2A2 | 161 | 212159_x_at | -0.0276 | 0.8761 | |
| GSE23400 | AP2A2 | 161 | 211779_x_at | 0.0983 | 0.1642 | |
| GSE26886 | AP2A2 | 161 | 211779_x_at | 0.3539 | 0.0957 | |
| GSE29001 | AP2A2 | 161 | 215764_x_at | 0.0518 | 0.8253 | |
| GSE38129 | AP2A2 | 161 | 212159_x_at | -0.0985 | 0.4936 | |
| GSE45670 | AP2A2 | 161 | 211779_x_at | -0.0758 | 0.5827 | |
| GSE53622 | AP2A2 | 161 | 96643 | 0.1721 | 0.0062 | |
| GSE53624 | AP2A2 | 161 | 75461 | 0.3119 | 0.0001 | |
| GSE63941 | AP2A2 | 161 | 212159_x_at | -0.6348 | 0.0739 | |
| GSE77861 | AP2A2 | 161 | 215764_x_at | -0.0141 | 0.9461 | |
| GSE97050 | AP2A2 | 161 | A_24_P932418 | -0.2291 | 0.4856 | |
| SRP007169 | AP2A2 | 161 | RNAseq | 1.1008 | 0.0194 | |
| SRP008496 | AP2A2 | 161 | RNAseq | 0.8874 | 0.0034 | |
| SRP064894 | AP2A2 | 161 | RNAseq | 0.3554 | 0.0827 | |
| SRP133303 | AP2A2 | 161 | RNAseq | -0.0375 | 0.8135 | |
| SRP159526 | AP2A2 | 161 | RNAseq | -0.1369 | 0.5537 | |
| SRP193095 | AP2A2 | 161 | RNAseq | 0.1984 | 0.1137 | |
| SRP219564 | AP2A2 | 161 | RNAseq | 0.1123 | 0.7757 | |
| TCGA | AP2A2 | 161 | RNAseq | -0.1355 | 0.0019 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AP2A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AP2A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AP2A2 | 161 | 1 | 11 | 18 | |
| GSE20123 | AP2A2 | 161 | 1 | 12 | 17 | |
| GSE43470 | AP2A2 | 161 | 1 | 10 | 32 | |
| GSE46452 | AP2A2 | 161 | 7 | 8 | 44 | |
| GSE47630 | AP2A2 | 161 | 4 | 12 | 24 | |
| GSE54993 | AP2A2 | 161 | 3 | 1 | 66 | |
| GSE54994 | AP2A2 | 161 | 1 | 12 | 40 | |
| GSE60625 | AP2A2 | 161 | 0 | 0 | 11 | |
| GSE74703 | AP2A2 | 161 | 1 | 8 | 27 | |
| GSE74704 | AP2A2 | 161 | 0 | 8 | 12 | |
| TCGA | AP2A2 | 161 | 9 | 38 | 49 |
Total number of gains: 28; Total number of losses: 120; Total Number of normals: 340.
Somatic mutations of AP2A2:
Generating mutation plots.
Highly correlated genes for AP2A2:
Showing top 20/554 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AP2A2 | RILP | 0.834133 | 3 | 0 | 3 |
| AP2A2 | ABCD2 | 0.774672 | 3 | 0 | 3 |
| AP2A2 | MEOX2 | 0.758647 | 3 | 0 | 3 |
| AP2A2 | PI16 | 0.756657 | 3 | 0 | 3 |
| AP2A2 | RAB7B | 0.755677 | 3 | 0 | 3 |
| AP2A2 | ZNRF3 | 0.751658 | 3 | 0 | 3 |
| AP2A2 | BEND5 | 0.740702 | 3 | 0 | 3 |
| AP2A2 | TMTC1 | 0.739873 | 3 | 0 | 3 |
| AP2A2 | FAM120AOS | 0.738713 | 3 | 0 | 3 |
| AP2A2 | LRRC41 | 0.732767 | 3 | 0 | 3 |
| AP2A2 | MEIS3 | 0.728275 | 4 | 0 | 4 |
| AP2A2 | SUGP1 | 0.718915 | 3 | 0 | 3 |
| AP2A2 | HNRNPUL1 | 0.717656 | 3 | 0 | 3 |
| AP2A2 | EBF1 | 0.715927 | 4 | 0 | 4 |
| AP2A2 | DNALI1 | 0.711426 | 4 | 0 | 4 |
| AP2A2 | CHADL | 0.711257 | 3 | 0 | 3 |
| AP2A2 | PRICKLE2 | 0.710013 | 3 | 0 | 3 |
| AP2A2 | SNTA1 | 0.708003 | 3 | 0 | 3 |
| AP2A2 | RNASEH2C | 0.707796 | 4 | 0 | 3 |
| AP2A2 | LSM11 | 0.706949 | 3 | 0 | 3 |
For details and further investigation, click here
