| Full name: HECT domain E3 ubiquitin protein ligase 1 | Alias Symbol: KIAA1131 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 25831 | HGNC ID: HGNC:20157 | Ensembl Gene: ENSG00000092148 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of HECTD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HECTD1 | 25831 | 224481_s_at | 0.1571 | 0.8501 | |
| GSE26886 | HECTD1 | 25831 | 224481_s_at | -1.2759 | 0.0000 | |
| GSE45670 | HECTD1 | 25831 | 224481_s_at | -0.4377 | 0.0043 | |
| GSE53622 | HECTD1 | 25831 | 136936 | -0.9103 | 0.0000 | |
| GSE53624 | HECTD1 | 25831 | 136936 | -1.0344 | 0.0000 | |
| GSE63941 | HECTD1 | 25831 | 224481_s_at | -0.2065 | 0.7223 | |
| GSE77861 | HECTD1 | 25831 | 224481_s_at | -0.4971 | 0.1737 | |
| GSE97050 | HECTD1 | 25831 | A_23_P54006 | -0.2707 | 0.2185 | |
| SRP007169 | HECTD1 | 25831 | RNAseq | -0.6495 | 0.1050 | |
| SRP008496 | HECTD1 | 25831 | RNAseq | -0.8197 | 0.0055 | |
| SRP064894 | HECTD1 | 25831 | RNAseq | -1.5401 | 0.0000 | |
| SRP133303 | HECTD1 | 25831 | RNAseq | -0.5852 | 0.0006 | |
| SRP159526 | HECTD1 | 25831 | RNAseq | -1.0761 | 0.0001 | |
| SRP193095 | HECTD1 | 25831 | RNAseq | -1.0934 | 0.0000 | |
| SRP219564 | HECTD1 | 25831 | RNAseq | -0.9908 | 0.0499 | |
| TCGA | HECTD1 | 25831 | RNAseq | -0.1225 | 0.0104 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by HECTD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HECTD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HECTD1 | 25831 | 9 | 4 | 17 | |
| GSE20123 | HECTD1 | 25831 | 9 | 4 | 17 | |
| GSE43470 | HECTD1 | 25831 | 10 | 2 | 31 | |
| GSE46452 | HECTD1 | 25831 | 18 | 2 | 39 | |
| GSE47630 | HECTD1 | 25831 | 11 | 10 | 19 | |
| GSE54993 | HECTD1 | 25831 | 3 | 11 | 56 | |
| GSE54994 | HECTD1 | 25831 | 19 | 5 | 29 | |
| GSE60625 | HECTD1 | 25831 | 0 | 2 | 9 | |
| GSE74703 | HECTD1 | 25831 | 9 | 2 | 25 | |
| GSE74704 | HECTD1 | 25831 | 4 | 3 | 13 | |
| TCGA | HECTD1 | 25831 | 33 | 15 | 48 |
Total number of gains: 125; Total number of losses: 60; Total Number of normals: 303.
Somatic mutations of HECTD1:
Generating mutation plots.
Highly correlated genes for HECTD1:
Showing top 20/723 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HECTD1 | NCCRP1 | 0.829214 | 3 | 0 | 3 |
| HECTD1 | FAM163B | 0.815149 | 3 | 0 | 3 |
| HECTD1 | APOA1 | 0.81348 | 3 | 0 | 3 |
| HECTD1 | KRT13 | 0.788823 | 5 | 0 | 5 |
| HECTD1 | MUC22 | 0.778919 | 3 | 0 | 3 |
| HECTD1 | ABLIM3 | 0.777017 | 6 | 0 | 6 |
| HECTD1 | VSIG10L | 0.775409 | 6 | 0 | 5 |
| HECTD1 | KRTAP20-1 | 0.774692 | 3 | 0 | 3 |
| HECTD1 | PMM1 | 0.774191 | 6 | 0 | 6 |
| HECTD1 | TTC9 | 0.771324 | 5 | 0 | 5 |
| HECTD1 | DEGS2 | 0.770992 | 6 | 0 | 6 |
| HECTD1 | KPRP | 0.768272 | 3 | 0 | 3 |
| HECTD1 | PRSS27 | 0.766897 | 6 | 0 | 6 |
| HECTD1 | CEACAM1 | 0.761839 | 5 | 0 | 5 |
| HECTD1 | SLURP1 | 0.761524 | 6 | 0 | 5 |
| HECTD1 | HES5 | 0.760355 | 4 | 0 | 4 |
| HECTD1 | CAPN5 | 0.760155 | 5 | 0 | 5 |
| HECTD1 | SH3BGRL2 | 0.758844 | 5 | 0 | 5 |
| HECTD1 | SPINK7 | 0.756453 | 6 | 0 | 6 |
| HECTD1 | SCNN1B | 0.755934 | 6 | 0 | 6 |
For details and further investigation, click here
