| Full name: transmembrane serine protease 11A | Alias Symbol: ECRG1 | ||
| Type: protein-coding gene | Cytoband: 4q13.2 | ||
| Entrez ID: 339967 | HGNC ID: HGNC:27954 | Ensembl Gene: ENSG00000187054 | OMIM ID: 611704 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS11A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | TMPRSS11A | 339967 | 45582 | -3.2235 | 0.0000 | |
| GSE53624 | TMPRSS11A | 339967 | 45582 | -3.8042 | 0.0000 | |
| GSE97050 | TMPRSS11A | 339967 | A_24_P109101 | -1.2647 | 0.1727 | |
| SRP007169 | TMPRSS11A | 339967 | RNAseq | -3.1402 | 0.0000 | |
| SRP008496 | TMPRSS11A | 339967 | RNAseq | -4.1823 | 0.0000 | |
| SRP064894 | TMPRSS11A | 339967 | RNAseq | -2.6470 | 0.0012 | |
| SRP133303 | TMPRSS11A | 339967 | RNAseq | -2.3592 | 0.0024 | |
| SRP159526 | TMPRSS11A | 339967 | RNAseq | -3.9579 | 0.0000 | |
| SRP219564 | TMPRSS11A | 339967 | RNAseq | -4.7053 | 0.0011 | |
| TCGA | TMPRSS11A | 339967 | RNAseq | 0.8521 | 0.0864 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by TMPRSS11A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS11A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS11A | 339967 | 2 | 11 | 17 | |
| GSE20123 | TMPRSS11A | 339967 | 2 | 12 | 16 | |
| GSE43470 | TMPRSS11A | 339967 | 0 | 13 | 30 | |
| GSE46452 | TMPRSS11A | 339967 | 2 | 35 | 22 | |
| GSE47630 | TMPRSS11A | 339967 | 0 | 19 | 21 | |
| GSE54993 | TMPRSS11A | 339967 | 7 | 0 | 63 | |
| GSE54994 | TMPRSS11A | 339967 | 1 | 9 | 43 | |
| GSE60625 | TMPRSS11A | 339967 | 0 | 0 | 11 | |
| GSE74703 | TMPRSS11A | 339967 | 0 | 11 | 25 | |
| GSE74704 | TMPRSS11A | 339967 | 1 | 8 | 11 | |
| TCGA | TMPRSS11A | 339967 | 18 | 26 | 52 |
Total number of gains: 33; Total number of losses: 144; Total Number of normals: 311.
Somatic mutations of TMPRSS11A:
Generating mutation plots.
Highly correlated genes for TMPRSS11A:
Showing top 20/417 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS11A | TMPRSS11E | 0.906233 | 3 | 0 | 3 |
| TMPRSS11A | IL36A | 0.902195 | 3 | 0 | 3 |
| TMPRSS11A | C19orf57 | 0.897984 | 3 | 0 | 3 |
| TMPRSS11A | CEACAM3 | 0.886148 | 3 | 0 | 3 |
| TMPRSS11A | IQCF1 | 0.874975 | 3 | 0 | 3 |
| TMPRSS11A | PRSS27 | 0.862941 | 4 | 0 | 4 |
| TMPRSS11A | VSIG10L | 0.850801 | 3 | 0 | 3 |
| TMPRSS11A | KLK13 | 0.848382 | 4 | 0 | 4 |
| TMPRSS11A | APOA1 | 0.844304 | 3 | 0 | 3 |
| TMPRSS11A | LMO7 | 0.843702 | 3 | 0 | 3 |
| TMPRSS11A | CEACAM7 | 0.841251 | 4 | 0 | 4 |
| TMPRSS11A | CLCA4 | 0.840844 | 4 | 0 | 4 |
| TMPRSS11A | OTOP3 | 0.839745 | 3 | 0 | 3 |
| TMPRSS11A | SPATA19 | 0.837849 | 3 | 0 | 3 |
| TMPRSS11A | SCEL | 0.836524 | 4 | 0 | 4 |
| TMPRSS11A | EPS8L2 | 0.834807 | 3 | 0 | 3 |
| TMPRSS11A | NCR1 | 0.828364 | 3 | 0 | 3 |
| TMPRSS11A | DEGS2 | 0.826026 | 3 | 0 | 3 |
| TMPRSS11A | CD24 | 0.826012 | 3 | 0 | 3 |
| TMPRSS11A | S100A8 | 0.82275 | 3 | 0 | 3 |
For details and further investigation, click here
