| Full name: cytochrome P450 family 3 subfamily A member 7 | Alias Symbol: CP37|P450-HFLA | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 1551 | HGNC ID: HGNC:2640 | Ensembl Gene: ENSG00000160870 | OMIM ID: 605340 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP3A7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CYP3A7 | 1551 | 14814 | -1.6704 | 0.0000 | |
| GSE53624 | CYP3A7 | 1551 | 14814 | -2.7529 | 0.0000 | |
| GSE97050 | CYP3A7 | 1551 | A_23_P358917 | -0.0256 | 0.9636 | |
| TCGA | CYP3A7 | 1551 | RNAseq | 0.5463 | 0.5552 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CYP3A7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP3A7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP3A7 | 1551 | 13 | 0 | 17 | |
| GSE20123 | CYP3A7 | 1551 | 13 | 0 | 17 | |
| GSE43470 | CYP3A7 | 1551 | 6 | 1 | 36 | |
| GSE46452 | CYP3A7 | 1551 | 11 | 1 | 47 | |
| GSE47630 | CYP3A7 | 1551 | 8 | 3 | 29 | |
| GSE54993 | CYP3A7 | 1551 | 1 | 9 | 60 | |
| GSE54994 | CYP3A7 | 1551 | 15 | 4 | 34 | |
| GSE60625 | CYP3A7 | 1551 | 0 | 0 | 11 | |
| GSE74703 | CYP3A7 | 1551 | 6 | 1 | 29 | |
| GSE74704 | CYP3A7 | 1551 | 9 | 0 | 11 | |
| TCGA | CYP3A7 | 1551 | 53 | 5 | 38 |
Total number of gains: 135; Total number of losses: 24; Total Number of normals: 329.
Somatic mutations of CYP3A7:
Generating mutation plots.
Highly correlated genes for CYP3A7:
Showing top 20/301 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP3A7 | CYP3A5 | 0.955948 | 3 | 0 | 3 |
| CYP3A7 | SCNN1B | 0.82606 | 3 | 0 | 3 |
| CYP3A7 | ELN | 0.813877 | 3 | 0 | 3 |
| CYP3A7 | STX19 | 0.811309 | 3 | 0 | 3 |
| CYP3A7 | DEGS2 | 0.807778 | 3 | 0 | 3 |
| CYP3A7 | CEACAM1 | 0.806929 | 3 | 0 | 3 |
| CYP3A7 | CEACAM5 | 0.80231 | 3 | 0 | 3 |
| CYP3A7 | SPATA19 | 0.801976 | 3 | 0 | 3 |
| CYP3A7 | VSIG10L | 0.796106 | 3 | 0 | 3 |
| CYP3A7 | ACOT8 | 0.795525 | 3 | 0 | 3 |
| CYP3A7 | RAET1E | 0.79487 | 3 | 0 | 3 |
| CYP3A7 | CEACAM3 | 0.788838 | 3 | 0 | 3 |
| CYP3A7 | NCCRP1 | 0.785445 | 3 | 0 | 3 |
| CYP3A7 | NCR1 | 0.784456 | 3 | 0 | 3 |
| CYP3A7 | PTK6 | 0.784415 | 3 | 0 | 3 |
| CYP3A7 | SLC13A4 | 0.781806 | 3 | 0 | 3 |
| CYP3A7 | IQCF1 | 0.78071 | 3 | 0 | 3 |
| CYP3A7 | PRSS27 | 0.780658 | 3 | 0 | 3 |
| CYP3A7 | NANOS2 | 0.778611 | 3 | 0 | 3 |
| CYP3A7 | CLCA4 | 0.778151 | 3 | 0 | 3 |
For details and further investigation, click here
