| Full name: apolipoprotein L4 | Alias Symbol: APOLIV | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 80832 | HGNC ID: HGNC:14867 | Ensembl Gene: ENSG00000100336 | OMIM ID: 607254 |
| Drug and gene relationship at DGIdb | |||
Expression of APOL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOL4 | 80832 | 1555600_s_at | 0.2212 | 0.7127 | |
| GSE26886 | APOL4 | 80832 | 223801_s_at | -0.0221 | 0.9030 | |
| GSE45670 | APOL4 | 80832 | 223801_s_at | 0.0222 | 0.8885 | |
| GSE53622 | APOL4 | 80832 | 31684 | 0.6304 | 0.0000 | |
| GSE53624 | APOL4 | 80832 | 31684 | 0.6923 | 0.0000 | |
| GSE63941 | APOL4 | 80832 | 224491_at | -0.0726 | 0.7597 | |
| GSE77861 | APOL4 | 80832 | 1555600_s_at | 0.1690 | 0.5783 | |
| GSE97050 | APOL4 | 80832 | A_33_P3232523 | -0.2585 | 0.4870 | |
| SRP007169 | APOL4 | 80832 | RNAseq | 1.2358 | 0.0115 | |
| SRP064894 | APOL4 | 80832 | RNAseq | 0.6938 | 0.0040 | |
| SRP133303 | APOL4 | 80832 | RNAseq | 0.2269 | 0.0176 | |
| SRP159526 | APOL4 | 80832 | RNAseq | 0.8588 | 0.1190 | |
| SRP193095 | APOL4 | 80832 | RNAseq | 0.2169 | 0.0535 | |
| SRP219564 | APOL4 | 80832 | RNAseq | 1.6364 | 0.0034 | |
| TCGA | APOL4 | 80832 | RNAseq | 0.0199 | 0.9107 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by APOL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOL4 | 80832 | 6 | 6 | 18 | |
| GSE20123 | APOL4 | 80832 | 6 | 5 | 19 | |
| GSE43470 | APOL4 | 80832 | 4 | 6 | 33 | |
| GSE46452 | APOL4 | 80832 | 31 | 1 | 27 | |
| GSE47630 | APOL4 | 80832 | 8 | 5 | 27 | |
| GSE54993 | APOL4 | 80832 | 3 | 6 | 61 | |
| GSE54994 | APOL4 | 80832 | 9 | 9 | 35 | |
| GSE60625 | APOL4 | 80832 | 5 | 0 | 6 | |
| GSE74703 | APOL4 | 80832 | 4 | 4 | 28 | |
| GSE74704 | APOL4 | 80832 | 3 | 2 | 15 | |
| TCGA | APOL4 | 80832 | 27 | 15 | 54 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of APOL4:
Generating mutation plots.
Highly correlated genes for APOL4:
Showing top 20/47 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOL4 | CD28 | 0.737628 | 3 | 0 | 3 |
| APOL4 | CFP | 0.723153 | 3 | 0 | 3 |
| APOL4 | TKTL1 | 0.716965 | 3 | 0 | 3 |
| APOL4 | SIGLEC7 | 0.714245 | 4 | 0 | 3 |
| APOL4 | TSPAN11 | 0.701537 | 3 | 0 | 3 |
| APOL4 | OR7A17 | 0.699315 | 3 | 0 | 3 |
| APOL4 | LDHC | 0.686713 | 3 | 0 | 3 |
| APOL4 | ZNF219 | 0.678317 | 3 | 0 | 3 |
| APOL4 | TLR9 | 0.670832 | 3 | 0 | 3 |
| APOL4 | RENBP | 0.670587 | 4 | 0 | 3 |
| APOL4 | PRAME | 0.663089 | 3 | 0 | 3 |
| APOL4 | LAG3 | 0.658796 | 5 | 0 | 5 |
| APOL4 | GGTLC1 | 0.653585 | 3 | 0 | 3 |
| APOL4 | ZDHHC19 | 0.649906 | 3 | 0 | 3 |
| APOL4 | FMNL1 | 0.64671 | 4 | 0 | 3 |
| APOL4 | CCL26 | 0.642359 | 4 | 0 | 3 |
| APOL4 | SPACA3 | 0.641211 | 4 | 0 | 3 |
| APOL4 | S100A4 | 0.633135 | 3 | 0 | 3 |
| APOL4 | GMFG | 0.631588 | 4 | 0 | 3 |
| APOL4 | CBFA2T3 | 0.61888 | 3 | 0 | 3 |
For details and further investigation, click here
