| Full name: CD28 molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q33.2 | ||
| Entrez ID: 940 | HGNC ID: HGNC:1653 | Ensembl Gene: ENSG00000178562 | OMIM ID: 186760 |
| Drug and gene relationship at DGIdb | |||
CD28 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04660 | T cell receptor signaling pathway | |
| hsa05162 | Measles |
Expression of CD28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD28 | 940 | 206545_at | 0.1504 | 0.8443 | |
| GSE20347 | CD28 | 940 | 211856_x_at | -0.0066 | 0.9294 | |
| GSE23400 | CD28 | 940 | 211856_x_at | -0.0485 | 0.1203 | |
| GSE26886 | CD28 | 940 | 211856_x_at | 0.0086 | 0.9342 | |
| GSE29001 | CD28 | 940 | 211856_x_at | 0.0436 | 0.7706 | |
| GSE38129 | CD28 | 940 | 211856_x_at | -0.0401 | 0.4815 | |
| GSE45670 | CD28 | 940 | 206545_at | 0.0435 | 0.8840 | |
| GSE53622 | CD28 | 940 | 138813 | -0.3264 | 0.0032 | |
| GSE53624 | CD28 | 940 | 138813 | -0.4952 | 0.0000 | |
| GSE63941 | CD28 | 940 | 211856_x_at | -0.0666 | 0.6088 | |
| GSE77861 | CD28 | 940 | 211856_x_at | -0.0661 | 0.4729 | |
| GSE97050 | CD28 | 940 | A_33_P3259253 | 0.4413 | 0.1956 | |
| SRP007169 | CD28 | 940 | RNAseq | 1.8486 | 0.0319 | |
| SRP064894 | CD28 | 940 | RNAseq | 0.1891 | 0.5296 | |
| SRP133303 | CD28 | 940 | RNAseq | -0.1938 | 0.4765 | |
| SRP159526 | CD28 | 940 | RNAseq | -0.3300 | 0.7003 | |
| SRP193095 | CD28 | 940 | RNAseq | 0.3498 | 0.1762 | |
| SRP219564 | CD28 | 940 | RNAseq | 0.4609 | 0.3261 | |
| TCGA | CD28 | 940 | RNAseq | 0.1498 | 0.5491 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CD28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD28 | 940 | 6 | 4 | 20 | |
| GSE20123 | CD28 | 940 | 6 | 4 | 20 | |
| GSE43470 | CD28 | 940 | 1 | 4 | 38 | |
| GSE46452 | CD28 | 940 | 1 | 4 | 54 | |
| GSE47630 | CD28 | 940 | 4 | 5 | 31 | |
| GSE54993 | CD28 | 940 | 0 | 3 | 67 | |
| GSE54994 | CD28 | 940 | 10 | 8 | 35 | |
| GSE60625 | CD28 | 940 | 0 | 3 | 8 | |
| GSE74703 | CD28 | 940 | 1 | 3 | 32 | |
| GSE74704 | CD28 | 940 | 3 | 2 | 15 | |
| TCGA | CD28 | 940 | 20 | 13 | 63 |
Total number of gains: 52; Total number of losses: 53; Total Number of normals: 383.
Somatic mutations of CD28:
Generating mutation plots.
Highly correlated genes for CD28:
Showing top 20/479 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD28 | CD52 | 0.806418 | 4 | 0 | 4 |
| CD28 | DOCK2 | 0.794464 | 5 | 0 | 5 |
| CD28 | EVI2A | 0.789635 | 3 | 0 | 3 |
| CD28 | CYTIP | 0.772996 | 3 | 0 | 3 |
| CD28 | CCR7 | 0.769289 | 4 | 0 | 4 |
| CD28 | IL10RA | 0.767943 | 4 | 0 | 4 |
| CD28 | DAB1 | 0.754787 | 4 | 0 | 4 |
| CD28 | IGFLR1 | 0.753476 | 4 | 0 | 4 |
| CD28 | PTPRC | 0.749238 | 4 | 0 | 4 |
| CD28 | APOL4 | 0.737628 | 3 | 0 | 3 |
| CD28 | CTSE | 0.719751 | 4 | 0 | 4 |
| CD28 | MPEG1 | 0.712473 | 3 | 0 | 3 |
| CD28 | CCR6 | 0.712411 | 3 | 0 | 3 |
| CD28 | SIGLEC10 | 0.694101 | 5 | 0 | 4 |
| CD28 | BANK1 | 0.685119 | 3 | 0 | 3 |
| CD28 | PLCL2 | 0.684286 | 4 | 0 | 3 |
| CD28 | LRTM2 | 0.680009 | 3 | 0 | 3 |
| CD28 | AQP8 | 0.673558 | 5 | 0 | 4 |
| CD28 | HECW1 | 0.67194 | 6 | 0 | 6 |
| CD28 | LIME1 | 0.671052 | 3 | 0 | 3 |
For details and further investigation, click here
