| Full name: lymphocyte activating 3 | Alias Symbol: CD223 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 3902 | HGNC ID: HGNC:6476 | Ensembl Gene: ENSG00000089692 | OMIM ID: 153337 |
| Drug and gene relationship at DGIdb | |||
Expression of LAG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAG3 | 3902 | 206486_at | 0.5916 | 0.3484 | |
| GSE20347 | LAG3 | 3902 | 206486_at | 0.2232 | 0.1009 | |
| GSE23400 | LAG3 | 3902 | 206486_at | -0.0289 | 0.6549 | |
| GSE26886 | LAG3 | 3902 | 206486_at | 0.1494 | 0.3855 | |
| GSE29001 | LAG3 | 3902 | 206486_at | 0.0058 | 0.9785 | |
| GSE38129 | LAG3 | 3902 | 206486_at | 0.1009 | 0.4951 | |
| GSE45670 | LAG3 | 3902 | 206486_at | 0.4924 | 0.0195 | |
| GSE53622 | LAG3 | 3902 | 23840 | 0.5962 | 0.0023 | |
| GSE53624 | LAG3 | 3902 | 23840 | 0.8400 | 0.0000 | |
| GSE63941 | LAG3 | 3902 | 206486_at | 0.1165 | 0.6932 | |
| GSE77861 | LAG3 | 3902 | 206486_at | -0.1778 | 0.3073 | |
| GSE97050 | LAG3 | 3902 | A_23_P116942 | 0.0838 | 0.7716 | |
| SRP064894 | LAG3 | 3902 | RNAseq | 0.3150 | 0.2383 | |
| SRP133303 | LAG3 | 3902 | RNAseq | 0.9908 | 0.0391 | |
| SRP159526 | LAG3 | 3902 | RNAseq | 0.7265 | 0.0830 | |
| SRP219564 | LAG3 | 3902 | RNAseq | 0.9531 | 0.2350 | |
| TCGA | LAG3 | 3902 | RNAseq | 0.6797 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LAG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAG3 | 3902 | 9 | 3 | 18 | |
| GSE20123 | LAG3 | 3902 | 9 | 3 | 18 | |
| GSE43470 | LAG3 | 3902 | 8 | 3 | 32 | |
| GSE46452 | LAG3 | 3902 | 10 | 1 | 48 | |
| GSE47630 | LAG3 | 3902 | 12 | 2 | 26 | |
| GSE54993 | LAG3 | 3902 | 1 | 10 | 59 | |
| GSE54994 | LAG3 | 3902 | 10 | 2 | 41 | |
| GSE60625 | LAG3 | 3902 | 0 | 1 | 10 | |
| GSE74703 | LAG3 | 3902 | 7 | 2 | 27 | |
| GSE74704 | LAG3 | 3902 | 5 | 2 | 13 | |
| TCGA | LAG3 | 3902 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.
Somatic mutations of LAG3:
Generating mutation plots.
Highly correlated genes for LAG3:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAG3 | NXF3 | 0.745118 | 3 | 0 | 3 |
| LAG3 | PRF1 | 0.693263 | 11 | 0 | 10 |
| LAG3 | GZMB | 0.682651 | 10 | 0 | 9 |
| LAG3 | EMID1 | 0.672575 | 3 | 0 | 3 |
| LAG3 | GNLY | 0.670054 | 10 | 0 | 9 |
| LAG3 | KLHDC7B | 0.665663 | 4 | 0 | 3 |
| LAG3 | CCR5 | 0.660829 | 8 | 0 | 6 |
| LAG3 | APOL4 | 0.658796 | 5 | 0 | 5 |
| LAG3 | NLRC5 | 0.652791 | 6 | 0 | 5 |
| LAG3 | IL10RA | 0.641352 | 10 | 0 | 9 |
| LAG3 | LAIR1 | 0.638443 | 8 | 0 | 7 |
| LAG3 | SPTBN5 | 0.637713 | 3 | 0 | 3 |
| LAG3 | GBP5 | 0.636595 | 6 | 0 | 5 |
| LAG3 | SIGLEC10 | 0.63327 | 7 | 0 | 7 |
| LAG3 | CXCL11 | 0.632009 | 9 | 0 | 7 |
| LAG3 | GZMH | 0.6318 | 9 | 0 | 8 |
| LAG3 | JAKMIP1 | 0.631438 | 6 | 0 | 5 |
| LAG3 | BATF2 | 0.63141 | 8 | 0 | 5 |
| LAG3 | SIGLEC7 | 0.630397 | 5 | 0 | 3 |
| LAG3 | IL2RB | 0.626754 | 10 | 0 | 8 |
For details and further investigation, click here
