| Full name: gamma-glutamyltransferase light chain 1 | Alias Symbol: dJ831C21.2|dJ831C21.1 | ||
| Type: protein-coding gene | Cytoband: 20p11.21 | ||
| Entrez ID: 92086 | HGNC ID: HGNC:16437 | Ensembl Gene: ENSG00000149435 | OMIM ID: 612338 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GGTLC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GGTLC1 | 92086 | 211416_x_at | 0.1340 | 0.6880 | |
| GSE20347 | GGTLC1 | 92086 | 211416_x_at | -0.0796 | 0.5987 | |
| GSE23400 | GGTLC1 | 92086 | 211416_x_at | -0.1021 | 0.0469 | |
| GSE26886 | GGTLC1 | 92086 | 211416_x_at | 0.3700 | 0.1003 | |
| GSE29001 | GGTLC1 | 92086 | 211416_x_at | -0.0714 | 0.7795 | |
| GSE38129 | GGTLC1 | 92086 | 211416_x_at | -0.0745 | 0.6136 | |
| GSE45670 | GGTLC1 | 92086 | 211416_x_at | 0.3659 | 0.0073 | |
| GSE53622 | GGTLC1 | 92086 | 22957 | -0.1270 | 0.1699 | |
| GSE53624 | GGTLC1 | 92086 | 22957 | -0.5872 | 0.0000 | |
| GSE63941 | GGTLC1 | 92086 | 211416_x_at | 0.4209 | 0.3251 | |
| GSE77861 | GGTLC1 | 92086 | 211416_x_at | 0.0364 | 0.8192 | |
| GSE97050 | GGTLC1 | A_21_P0012336 | -0.0469 | 0.8715 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GGTLC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GGTLC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GGTLC1 | 92086 | 12 | 2 | 16 | |
| GSE20123 | GGTLC1 | 92086 | 12 | 2 | 16 | |
| GSE43470 | GGTLC1 | 92086 | 12 | 1 | 30 | |
| GSE46452 | GGTLC1 | 92086 | 27 | 1 | 31 | |
| GSE47630 | GGTLC1 | 92086 | 17 | 4 | 19 | |
| GSE54993 | GGTLC1 | 92086 | 0 | 17 | 53 | |
| GSE54994 | GGTLC1 | 92086 | 27 | 1 | 25 | |
| GSE60625 | GGTLC1 | 92086 | 0 | 0 | 11 | |
| GSE74703 | GGTLC1 | 92086 | 10 | 1 | 25 | |
| GSE74704 | GGTLC1 | 92086 | 7 | 1 | 12 | |
| TCGA | GGTLC1 | 92086 | 44 | 9 | 43 |
Total number of gains: 168; Total number of losses: 39; Total Number of normals: 281.
Somatic mutations of GGTLC1:
Generating mutation plots.
Highly correlated genes for GGTLC1:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GGTLC1 | IL27RA | 0.782492 | 3 | 0 | 3 |
| GGTLC1 | RHPN1 | 0.780304 | 3 | 0 | 3 |
| GGTLC1 | C7orf61 | 0.775312 | 3 | 0 | 3 |
| GGTLC1 | RPA4 | 0.756768 | 3 | 0 | 3 |
| GGTLC1 | SALL3 | 0.751428 | 3 | 0 | 3 |
| GGTLC1 | PCSK1N | 0.749357 | 3 | 0 | 3 |
| GGTLC1 | ATP6AP1L | 0.724959 | 3 | 0 | 3 |
| GGTLC1 | MEP1A | 0.720537 | 3 | 0 | 3 |
| GGTLC1 | ANXA10 | 0.714182 | 3 | 0 | 3 |
| GGTLC1 | CAPN13 | 0.709165 | 3 | 0 | 3 |
| GGTLC1 | PAX3 | 0.696936 | 3 | 0 | 3 |
| GGTLC1 | ODF3B | 0.691548 | 3 | 0 | 3 |
| GGTLC1 | HK3 | 0.68679 | 4 | 0 | 4 |
| GGTLC1 | SSTR2 | 0.684526 | 3 | 0 | 3 |
| GGTLC1 | CDH4 | 0.678097 | 4 | 0 | 3 |
| GGTLC1 | SLC2A11 | 0.675647 | 4 | 0 | 3 |
| GGTLC1 | EBF4 | 0.675088 | 3 | 0 | 3 |
| GGTLC1 | ARHGAP22 | 0.671495 | 3 | 0 | 3 |
| GGTLC1 | TMC8 | 0.670996 | 3 | 0 | 3 |
| GGTLC1 | SPEF1 | 0.668632 | 5 | 0 | 4 |
For details and further investigation, click here
