| Full name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Alias Symbol: APPL | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 26060 | HGNC ID: HGNC:24035 | Ensembl Gene: ENSG00000157500 | OMIM ID: 604299 |
| Drug and gene relationship at DGIdb | |||
APPL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04211 | Longevity regulating pathway - mammal | |
| hsa05200 | Pathways in cancer | |
| hsa05210 | Colorectal cancer |
Expression of APPL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APPL1 | 26060 | 218158_s_at | -0.4057 | 0.3529 | |
| GSE20347 | APPL1 | 26060 | 218158_s_at | -0.9735 | 0.0000 | |
| GSE23400 | APPL1 | 26060 | 218158_s_at | -0.3626 | 0.0000 | |
| GSE26886 | APPL1 | 26060 | 218158_s_at | -1.4029 | 0.0000 | |
| GSE29001 | APPL1 | 26060 | 218158_s_at | -0.6684 | 0.0273 | |
| GSE38129 | APPL1 | 26060 | 218158_s_at | -0.7306 | 0.0000 | |
| GSE45670 | APPL1 | 26060 | 218158_s_at | -0.7258 | 0.0001 | |
| GSE53622 | APPL1 | 26060 | 93049 | -0.9839 | 0.0000 | |
| GSE53624 | APPL1 | 26060 | 93049 | -0.8628 | 0.0000 | |
| GSE63941 | APPL1 | 26060 | 222538_s_at | -0.6463 | 0.1645 | |
| GSE77861 | APPL1 | 26060 | 218158_s_at | -0.9814 | 0.0042 | |
| GSE97050 | APPL1 | 26060 | A_23_P166663 | -0.5525 | 0.0826 | |
| SRP007169 | APPL1 | 26060 | RNAseq | -1.1348 | 0.0003 | |
| SRP008496 | APPL1 | 26060 | RNAseq | -1.0481 | 0.0000 | |
| SRP064894 | APPL1 | 26060 | RNAseq | -0.6178 | 0.0028 | |
| SRP133303 | APPL1 | 26060 | RNAseq | -0.7655 | 0.0000 | |
| SRP159526 | APPL1 | 26060 | RNAseq | -0.6498 | 0.0029 | |
| SRP193095 | APPL1 | 26060 | RNAseq | -0.9466 | 0.0000 | |
| SRP219564 | APPL1 | 26060 | RNAseq | -0.9917 | 0.0118 | |
| TCGA | APPL1 | 26060 | RNAseq | -0.2087 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by APPL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APPL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APPL1 | 26060 | 0 | 17 | 13 | |
| GSE20123 | APPL1 | 26060 | 0 | 18 | 12 | |
| GSE43470 | APPL1 | 26060 | 0 | 17 | 26 | |
| GSE46452 | APPL1 | 26060 | 2 | 17 | 40 | |
| GSE47630 | APPL1 | 26060 | 1 | 24 | 15 | |
| GSE54993 | APPL1 | 26060 | 6 | 2 | 62 | |
| GSE54994 | APPL1 | 26060 | 0 | 32 | 21 | |
| GSE60625 | APPL1 | 26060 | 5 | 0 | 6 | |
| GSE74703 | APPL1 | 26060 | 0 | 14 | 22 | |
| GSE74704 | APPL1 | 26060 | 0 | 11 | 9 | |
| TCGA | APPL1 | 26060 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of APPL1:
Generating mutation plots.
Highly correlated genes for APPL1:
Showing top 20/1803 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APPL1 | CLEC3B | 0.805455 | 3 | 0 | 3 |
| APPL1 | DNAJB14 | 0.803902 | 3 | 0 | 3 |
| APPL1 | NAA35 | 0.798131 | 3 | 0 | 3 |
| APPL1 | EIF4E3 | 0.794931 | 6 | 0 | 6 |
| APPL1 | ATF6 | 0.784212 | 3 | 0 | 3 |
| APPL1 | PPM1K | 0.776187 | 6 | 0 | 6 |
| APPL1 | MTMR10 | 0.763857 | 7 | 0 | 7 |
| APPL1 | TMEM234 | 0.761632 | 4 | 0 | 4 |
| APPL1 | CCDC7 | 0.750775 | 4 | 0 | 3 |
| APPL1 | ZNF436 | 0.749541 | 5 | 0 | 5 |
| APPL1 | AKIRIN1 | 0.74792 | 3 | 0 | 3 |
| APPL1 | NIPSNAP3A | 0.746515 | 7 | 0 | 7 |
| APPL1 | WDR77 | 0.746106 | 3 | 0 | 3 |
| APPL1 | ZNF709 | 0.745707 | 3 | 0 | 3 |
| APPL1 | CYP21A2 | 0.744177 | 3 | 0 | 3 |
| APPL1 | RAB5A | 0.743281 | 10 | 0 | 10 |
| APPL1 | TCAIM | 0.740302 | 6 | 0 | 6 |
| APPL1 | NEIL1 | 0.739606 | 3 | 0 | 3 |
| APPL1 | ZNF823 | 0.73795 | 6 | 0 | 6 |
| APPL1 | LYRM7 | 0.737916 | 5 | 0 | 5 |
For details and further investigation, click here
