| Full name: WD repeat domain 77 | Alias Symbol: MEP50|p44 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 79084 | HGNC ID: HGNC:29652 | Ensembl Gene: ENSG00000116455 | OMIM ID: 611734 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WDR77:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR77 | 79084 | 201421_s_at | 0.0803 | 0.9050 | |
| GSE20347 | WDR77 | 79084 | 201421_s_at | 0.0417 | 0.7299 | |
| GSE23400 | WDR77 | 79084 | 201420_s_at | 0.2669 | 0.0000 | |
| GSE26886 | WDR77 | 79084 | 201421_s_at | -1.1134 | 0.0003 | |
| GSE29001 | WDR77 | 79084 | 201421_s_at | 0.2630 | 0.2832 | |
| GSE38129 | WDR77 | 79084 | 201421_s_at | 0.2480 | 0.0194 | |
| GSE45670 | WDR77 | 79084 | 201421_s_at | 0.2719 | 0.0715 | |
| GSE53622 | WDR77 | 79084 | 136214 | -0.2135 | 0.0061 | |
| GSE53624 | WDR77 | 79084 | 136214 | 0.0098 | 0.9183 | |
| GSE63941 | WDR77 | 79084 | 201420_s_at | 1.2859 | 0.0338 | |
| GSE77861 | WDR77 | 79084 | 201420_s_at | -0.0108 | 0.9420 | |
| GSE97050 | WDR77 | 79084 | A_23_P115149 | 0.2722 | 0.3085 | |
| SRP007169 | WDR77 | 79084 | RNAseq | 0.2788 | 0.4844 | |
| SRP008496 | WDR77 | 79084 | RNAseq | -0.1662 | 0.5473 | |
| SRP064894 | WDR77 | 79084 | RNAseq | 0.1950 | 0.3114 | |
| SRP133303 | WDR77 | 79084 | RNAseq | 0.2152 | 0.1818 | |
| SRP159526 | WDR77 | 79084 | RNAseq | -0.3231 | 0.0909 | |
| SRP193095 | WDR77 | 79084 | RNAseq | -0.0772 | 0.4523 | |
| SRP219564 | WDR77 | 79084 | RNAseq | 0.0473 | 0.8884 | |
| TCGA | WDR77 | 79084 | RNAseq | 0.0928 | 0.0800 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by WDR77 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR77:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR77 | 79084 | 0 | 10 | 20 | |
| GSE20123 | WDR77 | 79084 | 0 | 10 | 20 | |
| GSE43470 | WDR77 | 79084 | 0 | 8 | 35 | |
| GSE46452 | WDR77 | 79084 | 2 | 1 | 56 | |
| GSE47630 | WDR77 | 79084 | 9 | 5 | 26 | |
| GSE54993 | WDR77 | 79084 | 0 | 1 | 69 | |
| GSE54994 | WDR77 | 79084 | 7 | 4 | 42 | |
| GSE60625 | WDR77 | 79084 | 0 | 0 | 11 | |
| GSE74703 | WDR77 | 79084 | 0 | 7 | 29 | |
| GSE74704 | WDR77 | 79084 | 0 | 6 | 14 | |
| TCGA | WDR77 | 79084 | 7 | 27 | 62 |
Total number of gains: 25; Total number of losses: 79; Total Number of normals: 384.
Somatic mutations of WDR77:
Generating mutation plots.
Highly correlated genes for WDR77:
Showing top 20/480 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR77 | C2CD2 | 0.889342 | 3 | 0 | 3 |
| WDR77 | MSL3 | 0.844102 | 3 | 0 | 3 |
| WDR77 | NDUFA9 | 0.836224 | 3 | 0 | 3 |
| WDR77 | MKRN1 | 0.820278 | 3 | 0 | 3 |
| WDR77 | LPCAT3 | 0.807208 | 3 | 0 | 3 |
| WDR77 | ZNF436 | 0.806073 | 3 | 0 | 3 |
| WDR77 | TMEM218 | 0.793825 | 3 | 0 | 3 |
| WDR77 | TET2 | 0.784573 | 3 | 0 | 3 |
| WDR77 | CSTF2T | 0.778907 | 3 | 0 | 3 |
| WDR77 | GNL3 | 0.775871 | 3 | 0 | 3 |
| WDR77 | TNKS2 | 0.77573 | 3 | 0 | 3 |
| WDR77 | COMMD2 | 0.774243 | 3 | 0 | 3 |
| WDR77 | VPS26B | 0.77317 | 4 | 0 | 4 |
| WDR77 | MBNL3 | 0.772688 | 3 | 0 | 3 |
| WDR77 | AGPAT3 | 0.764763 | 3 | 0 | 3 |
| WDR77 | SMAD3 | 0.763515 | 3 | 0 | 3 |
| WDR77 | MGAT4A | 0.763497 | 3 | 0 | 3 |
| WDR77 | TAB3 | 0.762124 | 3 | 0 | 3 |
| WDR77 | FBXW2 | 0.760823 | 3 | 0 | 3 |
| WDR77 | DRAM2 | 0.758871 | 3 | 0 | 3 |
For details and further investigation, click here
