RAB5A

 

Full name: RAB5A, member RAS oncogene family Alias Symbol: 
Type: protein-coding gene Cytoband: 3p24.3
Entrez ID: 5868 HGNC ID: HGNC:9783 Ensembl Gene: ENSG00000144566 OMIM ID: 179512
Drug and gene relationship at DGIdb

 

RAB5A involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05152Tuberculosis

 

Expression of RAB5A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAB5A 5868 209089_at -0.4689 0.1386
GSE20347 RAB5A 5868 209089_at -0.9879 0.0000
GSE23400 RAB5A 5868 209089_at -0.5546 0.0000
GSE26886 RAB5A 5868 209089_at -1.2840 0.0000
GSE29001 RAB5A 5868 209089_at -0.7253 0.0003
GSE38129 RAB5A 5868 209089_at -0.8556 0.0000
GSE45670 RAB5A 5868 209089_at -0.4878 0.0028
GSE53622 RAB5A 5868 83330 -1.2412 0.0000
GSE53624 RAB5A 5868 83330 -1.0946 0.0000
GSE63941 RAB5A 5868 209089_at -0.5324 0.1612
GSE77861 RAB5A 5868 209089_at -0.9511 0.0005
GSE97050 RAB5A 5868 A_23_P212545 -0.5089 0.1297
SRP007169 RAB5A 5868 RNAseq -2.5147 0.0000
SRP008496 RAB5A 5868 RNAseq -2.2867 0.0000
SRP064894 RAB5A 5868 RNAseq -1.2021 0.0000
SRP133303 RAB5A 5868 RNAseq -0.8074 0.0000
SRP159526 RAB5A 5868 RNAseq -1.2239 0.0000
SRP193095 RAB5A 5868 RNAseq -1.3129 0.0000
SRP219564 RAB5A 5868 RNAseq -1.3180 0.0001
TCGA RAB5A 5868 RNAseq -0.1047 0.0273

Upregulated datasets: 0; Downregulated datasets: 9.  

 

Survival by RAB5A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAB5A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAB5A 5868 0 19 11
GSE20123 RAB5A 5868 0 19 11
GSE43470 RAB5A 5868 0 20 23
GSE46452 RAB5A 5868 2 17 40
GSE47630 RAB5A 5868 1 24 15
GSE54993 RAB5A 5868 6 1 63
GSE54994 RAB5A 5868 1 32 20
GSE60625 RAB5A 5868 5 0 6
GSE74703 RAB5A 5868 0 17 19
GSE74704 RAB5A 5868 0 13 7
TCGA RAB5A 5868 0 69 27

Total number of gains: 15; Total number of losses: 231; Total Number of normals: 242.  

 

Somatic mutations of RAB5A:

 

Generating mutation plots.

 

Highly correlated genes for RAB5A:

 

Showing top 20/1882 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAB5AANO100.87211110010
RAB5AACAA10.865548909
RAB5AKRT780.857773606
RAB5ACYSRT10.847336606
RAB5ACAPN140.836806606
RAB5ASFTA20.827383404
RAB5ALRRFIP20.81918713012
RAB5AA2ML10.816932606
RAB5ASCNN1B0.81569310010
RAB5AFAM3D0.815069606
RAB5AGDPD30.81342710010
RAB5ASMIM50.807149606
RAB5AKCTD60.804147707
RAB5ACWH430.80311210010
RAB5ACLIC30.802713808
RAB5ARMND5B0.80120711011
RAB5AGYS20.79958610010
RAB5AS100A160.79954606
RAB5AGBP60.797465404
RAB5APADI10.796906808

For details and further investigation, click here