| Full name: activating transcription factor 6 | Alias Symbol: ATF6A | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 22926 | HGNC ID: HGNC:791 | Ensembl Gene: ENSG00000118217 | OMIM ID: 605537 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ATF6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05010 | Alzheimer's disease |
Expression of ATF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATF6 | 22926 | 226941_at | -0.3385 | 0.3303 | |
| GSE20347 | ATF6 | 22926 | 203952_at | -0.2061 | 0.0516 | |
| GSE23400 | ATF6 | 22926 | 203952_at | 0.0235 | 0.4844 | |
| GSE26886 | ATF6 | 22926 | 226941_at | 0.4922 | 0.1103 | |
| GSE29001 | ATF6 | 22926 | 203952_at | -0.4049 | 0.0432 | |
| GSE38129 | ATF6 | 22926 | 203952_at | -0.0929 | 0.2608 | |
| GSE45670 | ATF6 | 22926 | 226941_at | -0.7496 | 0.0001 | |
| GSE53622 | ATF6 | 22926 | 68766 | 0.1294 | 0.0115 | |
| GSE53624 | ATF6 | 22926 | 68766 | 0.1309 | 0.1520 | |
| GSE63941 | ATF6 | 22926 | 203952_at | 0.6493 | 0.0427 | |
| GSE77861 | ATF6 | 22926 | 203952_at | 0.1421 | 0.4580 | |
| GSE97050 | ATF6 | 22926 | A_23_P62907 | 0.0114 | 0.9712 | |
| SRP007169 | ATF6 | 22926 | RNAseq | -0.2690 | 0.3810 | |
| SRP008496 | ATF6 | 22926 | RNAseq | 0.1270 | 0.5522 | |
| SRP064894 | ATF6 | 22926 | RNAseq | -0.0970 | 0.4054 | |
| SRP133303 | ATF6 | 22926 | RNAseq | 0.0925 | 0.3796 | |
| SRP159526 | ATF6 | 22926 | RNAseq | 0.2050 | 0.5336 | |
| SRP193095 | ATF6 | 22926 | RNAseq | -0.0459 | 0.5464 | |
| SRP219564 | ATF6 | 22926 | RNAseq | 0.1175 | 0.7007 | |
| TCGA | ATF6 | 22926 | RNAseq | -0.0369 | 0.4149 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATF6 | 22926 | 10 | 0 | 20 | |
| GSE20123 | ATF6 | 22926 | 10 | 0 | 20 | |
| GSE43470 | ATF6 | 22926 | 7 | 2 | 34 | |
| GSE46452 | ATF6 | 22926 | 2 | 1 | 56 | |
| GSE47630 | ATF6 | 22926 | 14 | 0 | 26 | |
| GSE54993 | ATF6 | 22926 | 0 | 5 | 65 | |
| GSE54994 | ATF6 | 22926 | 16 | 0 | 37 | |
| GSE60625 | ATF6 | 22926 | 0 | 0 | 11 | |
| GSE74703 | ATF6 | 22926 | 7 | 2 | 27 | |
| GSE74704 | ATF6 | 22926 | 4 | 0 | 16 | |
| TCGA | ATF6 | 22926 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of ATF6:
Generating mutation plots.
Highly correlated genes for ATF6:
Showing top 20/389 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATF6 | APPL1 | 0.784212 | 3 | 0 | 3 |
| ATF6 | TMEM50A | 0.759442 | 3 | 0 | 3 |
| ATF6 | DERA | 0.758594 | 3 | 0 | 3 |
| ATF6 | MACROD2 | 0.755428 | 3 | 0 | 3 |
| ATF6 | YPEL2 | 0.742404 | 3 | 0 | 3 |
| ATF6 | RNF125 | 0.740946 | 4 | 0 | 4 |
| ATF6 | SMARCA2 | 0.735884 | 3 | 0 | 3 |
| ATF6 | CCNY | 0.73555 | 4 | 0 | 4 |
| ATF6 | ZBTB44 | 0.734498 | 3 | 0 | 3 |
| ATF6 | N4BP2L1 | 0.731244 | 4 | 0 | 4 |
| ATF6 | LPAR1 | 0.729744 | 3 | 0 | 3 |
| ATF6 | MFAP1 | 0.72626 | 3 | 0 | 3 |
| ATF6 | CEP44 | 0.725345 | 5 | 0 | 5 |
| ATF6 | PPIL3 | 0.723381 | 3 | 0 | 3 |
| ATF6 | EPB41L5 | 0.722527 | 3 | 0 | 3 |
| ATF6 | TMBIM4 | 0.721127 | 4 | 0 | 3 |
| ATF6 | SWT1 | 0.716512 | 3 | 0 | 3 |
| ATF6 | AK3 | 0.716242 | 4 | 0 | 3 |
| ATF6 | SMU1 | 0.714916 | 4 | 0 | 4 |
| ATF6 | KIF16B | 0.714878 | 3 | 0 | 3 |
For details and further investigation, click here
