| Full name: aquaporin 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 343 | HGNC ID: HGNC:642 | Ensembl Gene: ENSG00000103375 | OMIM ID: 603750 |
| Drug and gene relationship at DGIdb | |||
Expression of AQP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AQP8 | 343 | 206784_at | 0.0966 | 0.7443 | |
| GSE20347 | AQP8 | 343 | 206784_at | 0.0216 | 0.8541 | |
| GSE23400 | AQP8 | 343 | 206784_at | -0.0308 | 0.4572 | |
| GSE26886 | AQP8 | 343 | 206784_at | -0.0967 | 0.5195 | |
| GSE29001 | AQP8 | 343 | 206784_at | -0.0878 | 0.6740 | |
| GSE38129 | AQP8 | 343 | 206784_at | -0.0324 | 0.7622 | |
| GSE45670 | AQP8 | 343 | 206784_at | 0.1302 | 0.2292 | |
| GSE53622 | AQP8 | 343 | 14694 | 0.0720 | 0.3949 | |
| GSE53624 | AQP8 | 343 | 14694 | -0.0613 | 0.4602 | |
| GSE63941 | AQP8 | 343 | 206784_at | 0.0790 | 0.6216 | |
| GSE77861 | AQP8 | 343 | 206784_at | -0.0128 | 0.9168 | |
| GSE97050 | AQP8 | 343 | A_23_P26522 | -0.1400 | 0.5259 | |
| TCGA | AQP8 | 343 | RNAseq | -2.2968 | 0.0287 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AQP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AQP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AQP8 | 343 | 4 | 4 | 22 | |
| GSE20123 | AQP8 | 343 | 4 | 3 | 23 | |
| GSE43470 | AQP8 | 343 | 4 | 3 | 36 | |
| GSE46452 | AQP8 | 343 | 38 | 1 | 20 | |
| GSE47630 | AQP8 | 343 | 11 | 6 | 23 | |
| GSE54993 | AQP8 | 343 | 3 | 5 | 62 | |
| GSE54994 | AQP8 | 343 | 4 | 9 | 40 | |
| GSE60625 | AQP8 | 343 | 4 | 0 | 7 | |
| GSE74703 | AQP8 | 343 | 4 | 2 | 30 | |
| GSE74704 | AQP8 | 343 | 2 | 1 | 17 | |
| TCGA | AQP8 | 343 | 19 | 13 | 64 |
Total number of gains: 97; Total number of losses: 47; Total Number of normals: 344.
Somatic mutations of AQP8:
Generating mutation plots.
Highly correlated genes for AQP8:
Showing top 20/944 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AQP8 | YY2 | 0.845832 | 3 | 0 | 3 |
| AQP8 | STRC | 0.835139 | 3 | 0 | 3 |
| AQP8 | KRTAP10-12 | 0.826802 | 3 | 0 | 3 |
| AQP8 | TTLL9 | 0.821764 | 3 | 0 | 3 |
| AQP8 | SLC22A12 | 0.820399 | 3 | 0 | 3 |
| AQP8 | LRRC3C | 0.817074 | 3 | 0 | 3 |
| AQP8 | OR10AD1 | 0.811297 | 3 | 0 | 3 |
| AQP8 | PRSS38 | 0.805658 | 3 | 0 | 3 |
| AQP8 | OR2B11 | 0.805051 | 3 | 0 | 3 |
| AQP8 | PLA2G2C | 0.802814 | 3 | 0 | 3 |
| AQP8 | DCDC1 | 0.797575 | 3 | 0 | 3 |
| AQP8 | OR4C3 | 0.797195 | 3 | 0 | 3 |
| AQP8 | OTOG | 0.795861 | 3 | 0 | 3 |
| AQP8 | DAB1 | 0.788807 | 5 | 0 | 5 |
| AQP8 | LHB | 0.787279 | 3 | 0 | 3 |
| AQP8 | OR2T1 | 0.784176 | 3 | 0 | 3 |
| AQP8 | OR2T27 | 0.783417 | 3 | 0 | 3 |
| AQP8 | PRR23B | 0.775775 | 3 | 0 | 3 |
| AQP8 | C19orf71 | 0.770197 | 3 | 0 | 3 |
| AQP8 | KCP | 0.769564 | 3 | 0 | 3 |
For details and further investigation, click here
