| Full name: interleukin 22 receptor subunit alpha 2 | Alias Symbol: CRF2-S1|IL-22BP | ||
| Type: protein-coding gene | Cytoband: 6q23.3 | ||
| Entrez ID: 116379 | HGNC ID: HGNC:14901 | Ensembl Gene: ENSG00000164485 | OMIM ID: 606648 |
| Drug and gene relationship at DGIdb | |||
IL22RA2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL22RA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL22RA2 | 116379 | 237493_at | 0.5462 | 0.4530 | |
| GSE26886 | IL22RA2 | 116379 | 237493_at | 0.0235 | 0.9518 | |
| GSE45670 | IL22RA2 | 116379 | 237493_at | 0.3194 | 0.0752 | |
| GSE53622 | IL22RA2 | 116379 | 9514 | 0.8576 | 0.0018 | |
| GSE53624 | IL22RA2 | 116379 | 93610 | 0.3331 | 0.0048 | |
| GSE63941 | IL22RA2 | 116379 | 237493_at | -0.0204 | 0.8939 | |
| GSE77861 | IL22RA2 | 116379 | 237493_at | -0.0381 | 0.5963 | |
| GSE97050 | IL22RA2 | 116379 | A_23_P168288 | 0.0990 | 0.6274 | |
| TCGA | IL22RA2 | 116379 | RNAseq | 1.6219 | 0.0028 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IL22RA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL22RA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL22RA2 | 116379 | 4 | 4 | 22 | |
| GSE20123 | IL22RA2 | 116379 | 3 | 3 | 24 | |
| GSE43470 | IL22RA2 | 116379 | 5 | 0 | 38 | |
| GSE46452 | IL22RA2 | 116379 | 3 | 10 | 46 | |
| GSE47630 | IL22RA2 | 116379 | 9 | 4 | 27 | |
| GSE54993 | IL22RA2 | 116379 | 3 | 2 | 65 | |
| GSE54994 | IL22RA2 | 116379 | 8 | 8 | 37 | |
| GSE60625 | IL22RA2 | 116379 | 0 | 1 | 10 | |
| GSE74703 | IL22RA2 | 116379 | 4 | 0 | 32 | |
| GSE74704 | IL22RA2 | 116379 | 1 | 1 | 18 | |
| TCGA | IL22RA2 | 116379 | 12 | 17 | 67 |
Total number of gains: 52; Total number of losses: 50; Total Number of normals: 386.
Somatic mutations of IL22RA2:
Generating mutation plots.
Highly correlated genes for IL22RA2:
Showing top 20/43 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL22RA2 | HGD | 0.836938 | 3 | 0 | 3 |
| IL22RA2 | SOHLH1 | 0.784148 | 3 | 0 | 3 |
| IL22RA2 | SH2D1B | 0.774822 | 3 | 0 | 3 |
| IL22RA2 | ZNF341 | 0.753319 | 3 | 0 | 3 |
| IL22RA2 | TP53INP1 | 0.748242 | 3 | 0 | 3 |
| IL22RA2 | ARFGEF1 | 0.731272 | 3 | 0 | 3 |
| IL22RA2 | CELA3B | 0.730692 | 3 | 0 | 3 |
| IL22RA2 | PKD2L1 | 0.726917 | 3 | 0 | 3 |
| IL22RA2 | DGKZ | 0.725302 | 3 | 0 | 3 |
| IL22RA2 | SLC34A1 | 0.720052 | 4 | 0 | 4 |
| IL22RA2 | ZNF568 | 0.719514 | 3 | 0 | 3 |
| IL22RA2 | RRP1 | 0.697226 | 3 | 0 | 3 |
| IL22RA2 | BMP8B | 0.695427 | 3 | 0 | 3 |
| IL22RA2 | BEST4 | 0.690141 | 3 | 0 | 3 |
| IL22RA2 | STK32C | 0.683324 | 4 | 0 | 3 |
| IL22RA2 | VILL | 0.68235 | 3 | 0 | 3 |
| IL22RA2 | ANKLE1 | 0.672956 | 4 | 0 | 3 |
| IL22RA2 | TRPS1 | 0.665098 | 3 | 0 | 3 |
| IL22RA2 | FABP6 | 0.664226 | 4 | 0 | 3 |
| IL22RA2 | CEL | 0.659272 | 3 | 0 | 3 |
For details and further investigation, click here
