CDK12

 

Full name: cyclin dependent kinase 12 Alias Symbol: CRK7|CRKR|KIAA0904
Type: protein-coding gene Cytoband: 17q12
Entrez ID: 51755 HGNC ID: HGNC:24224 Ensembl Gene: ENSG00000167258 OMIM ID: 615514
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 108/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CDK12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDK12 51755 225697_at 0.1180 0.7573
GSE20347 CDK12 51755 219226_at 0.2947 0.0563
GSE23400 CDK12 51755 213557_at 0.0394 0.5781
GSE26886 CDK12 51755 225694_at 0.8117 0.0085
GSE29001 CDK12 51755 219226_at 0.4782 0.0312
GSE38129 CDK12 51755 219226_at 0.3168 0.0014
GSE45670 CDK12 51755 225697_at 0.1625 0.4346
GSE53622 CDK12 51755 39637 0.3165 0.0000
GSE53624 CDK12 51755 39637 0.1468 0.0306
GSE63941 CDK12 51755 225694_at 0.3980 0.3713
GSE77861 CDK12 51755 225697_at 0.2420 0.0701
GSE97050 CDK12 51755 A_33_P3315801 0.1925 0.4267
SRP007169 CDK12 51755 RNAseq 0.7165 0.0862
SRP008496 CDK12 51755 RNAseq 0.7382 0.0015
SRP064894 CDK12 51755 RNAseq 0.0764 0.7064
SRP133303 CDK12 51755 RNAseq 0.2631 0.0076
SRP159526 CDK12 51755 RNAseq 0.0285 0.9195
SRP193095 CDK12 51755 RNAseq 0.2427 0.0052
SRP219564 CDK12 51755 RNAseq -0.0282 0.9303
TCGA CDK12 51755 RNAseq 0.0833 0.0676

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CDK12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDK12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDK12 51755 8 1 21
GSE20123 CDK12 51755 8 1 21
GSE43470 CDK12 51755 1 1 41
GSE46452 CDK12 51755 34 0 25
GSE47630 CDK12 51755 8 1 31
GSE54993 CDK12 51755 3 4 63
GSE54994 CDK12 51755 8 5 40
GSE60625 CDK12 51755 4 0 7
GSE74703 CDK12 51755 1 0 35
GSE74704 CDK12 51755 5 1 14
TCGA CDK12 51755 23 8 65

Total number of gains: 103; Total number of losses: 22; Total Number of normals: 363.  

 

Somatic mutations of CDK12:

 

Generating mutation plots.

 

Highly correlated genes for CDK12:

 

Showing top 20/144 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDK12RBM430.750614303
CDK12DCPS0.722194303
CDK12ZNF5260.712481303
CDK12UBE2I0.709575404
CDK12CDC340.706604303
CDK12NSUN60.700111303
CDK12PRR150.695626404
CDK12MS4A180.673903303
CDK12STAC30.673639303
CDK12ARFGEF10.672237303
CDK12FEN10.670096505
CDK12GNB1L0.669276303
CDK12ETV30.664462303
CDK12CCNL20.662825403
CDK12TAS2R310.662627303
CDK12ZNF7630.661278303
CDK12WRAP730.653574303
CDK12SLC1A40.649495303
CDK12EMC80.648951404
CDK12KLHL260.646048403

For details and further investigation, click here