| Full name: acetoacetyl-CoA synthetase | Alias Symbol: FLJ12389|SUR-5|ACSF1 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 65985 | HGNC ID: HGNC:21298 | Ensembl Gene: ENSG00000081760 | OMIM ID: 614364 |
| Drug and gene relationship at DGIdb | |||
Expression of AACS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AACS | 65985 | 218434_s_at | 0.2377 | 0.7727 | |
| GSE20347 | AACS | 65985 | 218434_s_at | -0.5877 | 0.0038 | |
| GSE23400 | AACS | 65985 | 218434_s_at | -0.2329 | 0.0402 | |
| GSE26886 | AACS | 65985 | 218434_s_at | -0.6863 | 0.0093 | |
| GSE29001 | AACS | 65985 | 218434_s_at | -0.2911 | 0.3508 | |
| GSE38129 | AACS | 65985 | 218434_s_at | -0.1438 | 0.5795 | |
| GSE45670 | AACS | 65985 | 218434_s_at | -0.0092 | 0.9653 | |
| GSE53622 | AACS | 65985 | 77801 | -0.4080 | 0.0074 | |
| GSE53624 | AACS | 65985 | 77801 | -0.3916 | 0.0000 | |
| GSE63941 | AACS | 65985 | 218434_s_at | -0.2028 | 0.6265 | |
| GSE77861 | AACS | 65985 | 218434_s_at | -0.3762 | 0.2494 | |
| GSE97050 | AACS | 65985 | A_33_P3403392 | 0.2346 | 0.3909 | |
| SRP007169 | AACS | 65985 | RNAseq | -0.9261 | 0.0112 | |
| SRP008496 | AACS | 65985 | RNAseq | -1.3706 | 0.0000 | |
| SRP064894 | AACS | 65985 | RNAseq | -0.5812 | 0.0004 | |
| SRP133303 | AACS | 65985 | RNAseq | -0.5912 | 0.0059 | |
| SRP159526 | AACS | 65985 | RNAseq | -0.5043 | 0.0591 | |
| SRP193095 | AACS | 65985 | RNAseq | -0.3554 | 0.0009 | |
| SRP219564 | AACS | 65985 | RNAseq | -0.2137 | 0.6407 | |
| TCGA | AACS | 65985 | RNAseq | 0.0364 | 0.6046 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AACS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AACS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AACS | 65985 | 4 | 5 | 21 | |
| GSE20123 | AACS | 65985 | 4 | 5 | 21 | |
| GSE43470 | AACS | 65985 | 2 | 0 | 41 | |
| GSE46452 | AACS | 65985 | 9 | 1 | 49 | |
| GSE47630 | AACS | 65985 | 9 | 3 | 28 | |
| GSE54993 | AACS | 65985 | 0 | 5 | 65 | |
| GSE54994 | AACS | 65985 | 4 | 8 | 41 | |
| GSE60625 | AACS | 65985 | 0 | 0 | 11 | |
| GSE74703 | AACS | 65985 | 2 | 0 | 34 | |
| GSE74704 | AACS | 65985 | 2 | 3 | 15 | |
| TCGA | AACS | 65985 | 21 | 12 | 63 |
Total number of gains: 57; Total number of losses: 42; Total Number of normals: 389.
Somatic mutations of AACS:
Generating mutation plots.
Highly correlated genes for AACS:
Showing top 20/540 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AACS | LCORL | 0.708392 | 3 | 0 | 3 |
| AACS | CNKSR1 | 0.694638 | 5 | 0 | 5 |
| AACS | ARFGEF1 | 0.680225 | 3 | 0 | 3 |
| AACS | RHOV | 0.678511 | 6 | 0 | 5 |
| AACS | MAL2 | 0.669355 | 7 | 0 | 6 |
| AACS | ARAP2 | 0.664468 | 3 | 0 | 3 |
| AACS | TMEM125 | 0.653591 | 3 | 0 | 3 |
| AACS | ZBTB7B | 0.652151 | 6 | 0 | 5 |
| AACS | PROM2 | 0.651058 | 7 | 0 | 6 |
| AACS | HCAR3 | 0.650977 | 7 | 0 | 6 |
| AACS | VDR | 0.648411 | 8 | 0 | 6 |
| AACS | PCAT6 | 0.644347 | 3 | 0 | 3 |
| AACS | MIOS | 0.643633 | 9 | 0 | 8 |
| AACS | CAMSAP3 | 0.64276 | 4 | 0 | 3 |
| AACS | CAPNS2 | 0.642472 | 3 | 0 | 3 |
| AACS | SDC1 | 0.642111 | 8 | 0 | 6 |
| AACS | FDXR | 0.640757 | 6 | 0 | 4 |
| AACS | PERP | 0.636469 | 10 | 0 | 7 |
| AACS | LAD1 | 0.635225 | 11 | 0 | 9 |
| AACS | GNA15 | 0.634538 | 11 | 0 | 10 |
For details and further investigation, click here
