| Full name: Rho GDP dissociation inhibitor gamma | Alias Symbol: RHOGDI-3 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 398 | HGNC ID: HGNC:680 | Ensembl Gene: ENSG00000242173 | OMIM ID: 602844 |
| Drug and gene relationship at DGIdb | |||
ARHGDIG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway | |
| hsa04962 | Vasopressin-regulated water reabsorption |
Expression of ARHGDIG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGDIG | 398 | 206888_s_at | -0.2438 | 0.2459 | |
| GSE20347 | ARHGDIG | 398 | 206888_s_at | -0.0260 | 0.8020 | |
| GSE23400 | ARHGDIG | 398 | 206888_s_at | -0.1263 | 0.0001 | |
| GSE26886 | ARHGDIG | 398 | 206888_s_at | 0.0552 | 0.6482 | |
| GSE29001 | ARHGDIG | 398 | 206888_s_at | -0.0679 | 0.5817 | |
| GSE38129 | ARHGDIG | 398 | 206888_s_at | -0.1698 | 0.0675 | |
| GSE45670 | ARHGDIG | 398 | 206888_s_at | 0.0728 | 0.4681 | |
| GSE53622 | ARHGDIG | 398 | 100711 | -0.3466 | 0.0046 | |
| GSE53624 | ARHGDIG | 398 | 100711 | -0.5562 | 0.0000 | |
| GSE63941 | ARHGDIG | 398 | 206888_s_at | 0.1598 | 0.5377 | |
| GSE77861 | ARHGDIG | 398 | 206888_s_at | -0.0136 | 0.9419 | |
| GSE97050 | ARHGDIG | 398 | A_24_P215882 | 0.0437 | 0.8963 | |
| TCGA | ARHGDIG | 398 | RNAseq | -4.0564 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ARHGDIG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGDIG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGDIG | 398 | 5 | 5 | 20 | |
| GSE20123 | ARHGDIG | 398 | 5 | 4 | 21 | |
| GSE43470 | ARHGDIG | 398 | 3 | 7 | 33 | |
| GSE46452 | ARHGDIG | 398 | 38 | 1 | 20 | |
| GSE47630 | ARHGDIG | 398 | 13 | 6 | 21 | |
| GSE54993 | ARHGDIG | 398 | 3 | 5 | 62 | |
| GSE54994 | ARHGDIG | 398 | 4 | 10 | 39 | |
| GSE60625 | ARHGDIG | 398 | 4 | 0 | 7 | |
| GSE74703 | ARHGDIG | 398 | 3 | 5 | 28 | |
| GSE74704 | ARHGDIG | 398 | 3 | 2 | 15 | |
| TCGA | ARHGDIG | 398 | 20 | 15 | 61 |
Total number of gains: 101; Total number of losses: 60; Total Number of normals: 327.
Somatic mutations of ARHGDIG:
Generating mutation plots.
Highly correlated genes for ARHGDIG:
Showing top 20/673 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGDIG | CRB2 | 0.785308 | 3 | 0 | 3 |
| ARHGDIG | RCOR2 | 0.778971 | 3 | 0 | 3 |
| ARHGDIG | JSRP1 | 0.774559 | 3 | 0 | 3 |
| ARHGDIG | FAM71F1 | 0.746581 | 3 | 0 | 3 |
| ARHGDIG | STX1B | 0.746174 | 3 | 0 | 3 |
| ARHGDIG | C7orf61 | 0.744302 | 3 | 0 | 3 |
| ARHGDIG | LGALS12 | 0.729516 | 3 | 0 | 3 |
| ARHGDIG | DEFB108B | 0.720124 | 3 | 0 | 3 |
| ARHGDIG | TXNDC2 | 0.712073 | 4 | 0 | 4 |
| ARHGDIG | MRAP | 0.708326 | 4 | 0 | 3 |
| ARHGDIG | COL20A1 | 0.700998 | 4 | 0 | 3 |
| ARHGDIG | CD300LB | 0.700767 | 3 | 0 | 3 |
| ARHGDIG | MOGAT3 | 0.695371 | 3 | 0 | 3 |
| ARHGDIG | PTPRCAP | 0.692954 | 3 | 0 | 3 |
| ARHGDIG | ZGLP1 | 0.690981 | 3 | 0 | 3 |
| ARHGDIG | LCN8 | 0.689777 | 3 | 0 | 3 |
| ARHGDIG | LRFN2 | 0.685752 | 3 | 0 | 3 |
| ARHGDIG | SLC18A3 | 0.679562 | 4 | 0 | 3 |
| ARHGDIG | FCRL2 | 0.678987 | 5 | 0 | 5 |
| ARHGDIG | VCX2 | 0.675251 | 5 | 0 | 3 |
For details and further investigation, click here
