| Full name: Rho guanine nucleotide exchange factor 28 | Alias Symbol: RGNEF|p190RhoGEF|RIP2 | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 64283 | HGNC ID: HGNC:30322 | Ensembl Gene: ENSG00000214944 | OMIM ID: 612790 |
Expression of ARHGEF28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF28 | 64283 | 1554003_at | -0.1716 | 0.7853 | |
| GSE20347 | ARHGEF28 | 64283 | 219610_at | -0.1154 | 0.4560 | |
| GSE23400 | ARHGEF28 | 64283 | 219610_at | 0.0070 | 0.8866 | |
| GSE26886 | ARHGEF28 | 64283 | 219610_at | 0.1308 | 0.7470 | |
| GSE29001 | ARHGEF28 | 64283 | 219610_at | -0.5081 | 0.1307 | |
| GSE38129 | ARHGEF28 | 64283 | 219610_at | -0.0958 | 0.5679 | |
| GSE45670 | ARHGEF28 | 64283 | 232994_s_at | 0.3283 | 0.1061 | |
| GSE53622 | ARHGEF28 | 64283 | 37393 | -0.1091 | 0.4164 | |
| GSE53624 | ARHGEF28 | 64283 | 37393 | -0.2837 | 0.0029 | |
| GSE63941 | ARHGEF28 | 64283 | 1554003_at | -0.2205 | 0.7634 | |
| GSE77861 | ARHGEF28 | 64283 | 1554003_at | -0.1955 | 0.3719 | |
| SRP007169 | ARHGEF28 | 64283 | RNAseq | -0.1083 | 0.8008 | |
| SRP008496 | ARHGEF28 | 64283 | RNAseq | -0.1632 | 0.5669 | |
| SRP064894 | ARHGEF28 | 64283 | RNAseq | -0.2352 | 0.2831 | |
| SRP133303 | ARHGEF28 | 64283 | RNAseq | -0.5916 | 0.0675 | |
| SRP159526 | ARHGEF28 | 64283 | RNAseq | 0.4289 | 0.0831 | |
| SRP193095 | ARHGEF28 | 64283 | RNAseq | -0.4910 | 0.0056 | |
| SRP219564 | ARHGEF28 | 64283 | RNAseq | -0.9498 | 0.0904 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGEF28 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ARHGEF28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF28 | 64283 | 1 | 13 | 16 | |
| GSE20123 | ARHGEF28 | 64283 | 1 | 13 | 16 | |
| GSE43470 | ARHGEF28 | 64283 | 1 | 13 | 29 | |
| GSE46452 | ARHGEF28 | 64283 | 0 | 28 | 31 | |
| GSE47630 | ARHGEF28 | 64283 | 1 | 19 | 20 | |
| GSE54993 | ARHGEF28 | 64283 | 8 | 1 | 61 | |
| GSE54994 | ARHGEF28 | 64283 | 1 | 19 | 33 | |
| GSE60625 | ARHGEF28 | 64283 | 0 | 0 | 11 | |
| GSE74703 | ARHGEF28 | 64283 | 1 | 9 | 26 | |
| GSE74704 | ARHGEF28 | 64283 | 1 | 6 | 13 | |
| TCGA | ARHGEF28 | 64283 | 5 | 50 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of ARHGEF28:
Generating mutation plots.
Highly correlated genes for ARHGEF28:
Showing all 16 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF28 | CTNNBIP1 | 0.609462 | 5 | 0 | 3 |
| ARHGEF28 | PIK3CB | 0.592169 | 4 | 0 | 3 |
| ARHGEF28 | BHMT | 0.590515 | 3 | 0 | 3 |
| ARHGEF28 | PTPN13 | 0.581353 | 3 | 0 | 3 |
| ARHGEF28 | RRH | 0.577752 | 3 | 0 | 3 |
| ARHGEF28 | H6PD | 0.576893 | 3 | 0 | 3 |
| ARHGEF28 | FRAT1 | 0.564287 | 5 | 0 | 4 |
| ARHGEF28 | RNF39 | 0.559541 | 4 | 0 | 3 |
| ARHGEF28 | CADM1 | 0.557318 | 3 | 0 | 3 |
| ARHGEF28 | MYCBP2 | 0.556088 | 3 | 0 | 3 |
| ARHGEF28 | TMEM62 | 0.544852 | 3 | 0 | 3 |
| ARHGEF28 | ACBD5 | 0.523443 | 4 | 0 | 3 |
| ARHGEF28 | BDH1 | 0.518664 | 7 | 0 | 3 |
| ARHGEF28 | UBE4B | 0.516378 | 5 | 0 | 3 |
| ARHGEF28 | FRAT2 | 0.515936 | 6 | 0 | 3 |
| ARHGEF28 | SUSD4 | 0.514526 | 5 | 0 | 3 |
For details and further investigation, click here
