| Full name: ubiquitination factor E4B | Alias Symbol: UBOX3|E4|UFD2|KIAA0684 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 10277 | HGNC ID: HGNC:12500 | Ensembl Gene: ENSG00000130939 | OMIM ID: 613565 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE4B | 10277 | 202317_s_at | -0.2077 | 0.6697 | |
| GSE20347 | UBE4B | 10277 | 202317_s_at | -0.1674 | 0.2144 | |
| GSE23400 | UBE4B | 10277 | 202317_s_at | -0.0755 | 0.2222 | |
| GSE26886 | UBE4B | 10277 | 202317_s_at | -0.5719 | 0.0017 | |
| GSE29001 | UBE4B | 10277 | 202317_s_at | -0.2405 | 0.4476 | |
| GSE38129 | UBE4B | 10277 | 202317_s_at | -0.2951 | 0.0107 | |
| GSE45670 | UBE4B | 10277 | 202317_s_at | -0.2093 | 0.0589 | |
| GSE53622 | UBE4B | 10277 | 40982 | -0.6693 | 0.0000 | |
| GSE53624 | UBE4B | 10277 | 40982 | -0.4321 | 0.0000 | |
| GSE63941 | UBE4B | 10277 | 202317_s_at | -0.4117 | 0.4592 | |
| GSE77861 | UBE4B | 10277 | 202317_s_at | -0.1453 | 0.5059 | |
| GSE97050 | UBE4B | 10277 | A_23_P201279 | -0.5136 | 0.1752 | |
| SRP007169 | UBE4B | 10277 | RNAseq | -0.2914 | 0.4659 | |
| SRP008496 | UBE4B | 10277 | RNAseq | -0.1301 | 0.6181 | |
| SRP064894 | UBE4B | 10277 | RNAseq | -0.2235 | 0.1187 | |
| SRP133303 | UBE4B | 10277 | RNAseq | -0.2545 | 0.0733 | |
| SRP159526 | UBE4B | 10277 | RNAseq | -0.2745 | 0.2831 | |
| SRP193095 | UBE4B | 10277 | RNAseq | -0.0508 | 0.6795 | |
| SRP219564 | UBE4B | 10277 | RNAseq | -0.5680 | 0.0567 | |
| TCGA | UBE4B | 10277 | RNAseq | -0.0950 | 0.0408 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBE4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE4B | 10277 | 0 | 5 | 25 | |
| GSE20123 | UBE4B | 10277 | 0 | 3 | 27 | |
| GSE43470 | UBE4B | 10277 | 6 | 5 | 32 | |
| GSE46452 | UBE4B | 10277 | 7 | 1 | 51 | |
| GSE47630 | UBE4B | 10277 | 8 | 4 | 28 | |
| GSE54993 | UBE4B | 10277 | 3 | 1 | 66 | |
| GSE54994 | UBE4B | 10277 | 12 | 4 | 37 | |
| GSE60625 | UBE4B | 10277 | 0 | 0 | 11 | |
| GSE74703 | UBE4B | 10277 | 5 | 3 | 28 | |
| GSE74704 | UBE4B | 10277 | 0 | 0 | 20 | |
| TCGA | UBE4B | 10277 | 10 | 24 | 62 |
Total number of gains: 51; Total number of losses: 50; Total Number of normals: 387.
Somatic mutations of UBE4B:
Generating mutation plots.
Highly correlated genes for UBE4B:
Showing top 20/735 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE4B | MKRN1 | 0.845146 | 3 | 0 | 3 |
| UBE4B | ZNF564 | 0.800345 | 3 | 0 | 3 |
| UBE4B | SLC25A3 | 0.779123 | 4 | 0 | 4 |
| UBE4B | MRPS36 | 0.76829 | 3 | 0 | 3 |
| UBE4B | AP3M1 | 0.762272 | 4 | 0 | 4 |
| UBE4B | GGA3 | 0.749572 | 4 | 0 | 4 |
| UBE4B | ICA1L | 0.748893 | 3 | 0 | 3 |
| UBE4B | FBXO10 | 0.745391 | 3 | 0 | 3 |
| UBE4B | HADHA | 0.736456 | 3 | 0 | 3 |
| UBE4B | NBR1 | 0.733997 | 4 | 0 | 4 |
| UBE4B | CYB5D1 | 0.733865 | 3 | 0 | 3 |
| UBE4B | CCDC3 | 0.733069 | 3 | 0 | 3 |
| UBE4B | TTC19 | 0.729272 | 3 | 0 | 3 |
| UBE4B | TMEM218 | 0.728865 | 3 | 0 | 3 |
| UBE4B | TOB2 | 0.726858 | 3 | 0 | 3 |
| UBE4B | HINT3 | 0.724744 | 3 | 0 | 3 |
| UBE4B | PPP1R3B | 0.723387 | 3 | 0 | 3 |
| UBE4B | MEAF6 | 0.722435 | 4 | 0 | 4 |
| UBE4B | LIN7B | 0.721662 | 3 | 0 | 3 |
| UBE4B | APPBP2 | 0.71899 | 5 | 0 | 5 |
For details and further investigation, click here
