| Full name: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 9563 | HGNC ID: HGNC:4795 | Ensembl Gene: ENSG00000049239 | OMIM ID: 138090 |
| Drug and gene relationship at DGIdb | |||
Expression of H6PD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | H6PD | 9563 | 226160_at | 0.0200 | 0.9817 | |
| GSE20347 | H6PD | 9563 | 221892_at | -0.0795 | 0.5461 | |
| GSE23400 | H6PD | 9563 | 221892_at | -0.0558 | 0.2046 | |
| GSE26886 | H6PD | 9563 | 226160_at | 0.2950 | 0.2492 | |
| GSE29001 | H6PD | 9563 | 221892_at | -0.1065 | 0.6145 | |
| GSE38129 | H6PD | 9563 | 221892_at | -0.1131 | 0.3453 | |
| GSE45670 | H6PD | 9563 | 221892_at | -0.2016 | 0.1777 | |
| GSE53622 | H6PD | 9563 | 41274 | -0.2232 | 0.0364 | |
| GSE53624 | H6PD | 9563 | 41274 | -0.1521 | 0.3147 | |
| GSE63941 | H6PD | 9563 | 226160_at | 0.2516 | 0.6529 | |
| GSE77861 | H6PD | 9563 | 226160_at | -0.0029 | 0.9915 | |
| GSE97050 | H6PD | 9563 | A_24_P626850 | 0.1477 | 0.4486 | |
| SRP007169 | H6PD | 9563 | RNAseq | 0.3831 | 0.3925 | |
| SRP008496 | H6PD | 9563 | RNAseq | 0.5802 | 0.0472 | |
| SRP064894 | H6PD | 9563 | RNAseq | 0.2342 | 0.1596 | |
| SRP133303 | H6PD | 9563 | RNAseq | -0.1912 | 0.2865 | |
| SRP159526 | H6PD | 9563 | RNAseq | -0.0146 | 0.9590 | |
| SRP193095 | H6PD | 9563 | RNAseq | 0.0513 | 0.6383 | |
| SRP219564 | H6PD | 9563 | RNAseq | 0.6505 | 0.1193 | |
| TCGA | H6PD | 9563 | RNAseq | -0.1695 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by H6PD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of H6PD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | H6PD | 9563 | 1 | 5 | 24 | |
| GSE20123 | H6PD | 9563 | 1 | 3 | 26 | |
| GSE43470 | H6PD | 9563 | 6 | 5 | 32 | |
| GSE46452 | H6PD | 9563 | 7 | 1 | 51 | |
| GSE47630 | H6PD | 9563 | 8 | 4 | 28 | |
| GSE54993 | H6PD | 9563 | 3 | 2 | 65 | |
| GSE54994 | H6PD | 9563 | 12 | 4 | 37 | |
| GSE60625 | H6PD | 9563 | 0 | 0 | 11 | |
| GSE74703 | H6PD | 9563 | 5 | 3 | 28 | |
| GSE74704 | H6PD | 9563 | 1 | 0 | 19 | |
| TCGA | H6PD | 9563 | 10 | 24 | 62 |
Total number of gains: 54; Total number of losses: 51; Total Number of normals: 383.
Somatic mutations of H6PD:
Generating mutation plots.
Highly correlated genes for H6PD:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| H6PD | TCN2 | 0.704668 | 3 | 0 | 3 |
| H6PD | RGS18 | 0.690358 | 3 | 0 | 3 |
| H6PD | IL5RA | 0.6858 | 3 | 0 | 3 |
| H6PD | COL23A1 | 0.681366 | 3 | 0 | 3 |
| H6PD | ADAMDEC1 | 0.670955 | 3 | 0 | 3 |
| H6PD | PIGM | 0.669599 | 3 | 0 | 3 |
| H6PD | TGFBR1 | 0.66523 | 3 | 0 | 3 |
| H6PD | PRLR | 0.664691 | 4 | 0 | 3 |
| H6PD | RHOH | 0.664354 | 4 | 0 | 3 |
| H6PD | KLHL11 | 0.65974 | 3 | 0 | 3 |
| H6PD | KAT7 | 0.658225 | 3 | 0 | 3 |
| H6PD | VPS53 | 0.655788 | 3 | 0 | 3 |
| H6PD | C9orf40 | 0.654515 | 3 | 0 | 3 |
| H6PD | ZNF512 | 0.653401 | 3 | 0 | 3 |
| H6PD | ETS1 | 0.651893 | 3 | 0 | 3 |
| H6PD | SLFN12 | 0.651431 | 4 | 0 | 3 |
| H6PD | ESD | 0.651312 | 3 | 0 | 3 |
| H6PD | ZNF467 | 0.648364 | 4 | 0 | 3 |
| H6PD | MYCT1 | 0.647674 | 4 | 0 | 3 |
| H6PD | VPS41 | 0.646186 | 3 | 0 | 3 |
For details and further investigation, click here
