| Full name: protein tyrosine phosphatase non-receptor type 13 | Alias Symbol: PTP1E|PTP-BAS|PTPL1|PTP-BL | ||
| Type: protein-coding gene | Cytoband: 4q21.3 | ||
| Entrez ID: 5783 | HGNC ID: HGNC:9646 | Ensembl Gene: ENSG00000163629 | OMIM ID: 600267 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PTPN13 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of PTPN13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN13 | 5783 | 204201_s_at | 0.3912 | 0.6626 | |
| GSE20347 | PTPN13 | 5783 | 204201_s_at | -0.9805 | 0.0204 | |
| GSE23400 | PTPN13 | 5783 | 204201_s_at | -0.3100 | 0.0403 | |
| GSE26886 | PTPN13 | 5783 | 204201_s_at | -0.6072 | 0.0044 | |
| GSE29001 | PTPN13 | 5783 | 204201_s_at | -0.5241 | 0.2173 | |
| GSE38129 | PTPN13 | 5783 | 204201_s_at | -0.5430 | 0.1203 | |
| GSE45670 | PTPN13 | 5783 | 204201_s_at | 0.0904 | 0.7408 | |
| GSE53622 | PTPN13 | 5783 | 5888 | -0.5775 | 0.0000 | |
| GSE53624 | PTPN13 | 5783 | 5888 | -0.8804 | 0.0000 | |
| GSE63941 | PTPN13 | 5783 | 204201_s_at | -1.0662 | 0.2189 | |
| GSE77861 | PTPN13 | 5783 | 204201_s_at | -0.4847 | 0.2265 | |
| GSE97050 | PTPN13 | 5783 | A_23_P18493 | -0.1016 | 0.6242 | |
| SRP007169 | PTPN13 | 5783 | RNAseq | -0.3926 | 0.4160 | |
| SRP008496 | PTPN13 | 5783 | RNAseq | -0.4955 | 0.0514 | |
| SRP064894 | PTPN13 | 5783 | RNAseq | -1.1043 | 0.0011 | |
| SRP133303 | PTPN13 | 5783 | RNAseq | -0.5187 | 0.0357 | |
| SRP159526 | PTPN13 | 5783 | RNAseq | -1.3568 | 0.0000 | |
| SRP193095 | PTPN13 | 5783 | RNAseq | -0.6401 | 0.0521 | |
| SRP219564 | PTPN13 | 5783 | RNAseq | -1.2196 | 0.0562 | |
| TCGA | PTPN13 | 5783 | RNAseq | 0.2584 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PTPN13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN13 | 5783 | 3 | 12 | 15 | |
| GSE20123 | PTPN13 | 5783 | 3 | 12 | 15 | |
| GSE43470 | PTPN13 | 5783 | 0 | 13 | 30 | |
| GSE46452 | PTPN13 | 5783 | 2 | 35 | 22 | |
| GSE47630 | PTPN13 | 5783 | 0 | 20 | 20 | |
| GSE54993 | PTPN13 | 5783 | 8 | 0 | 62 | |
| GSE54994 | PTPN13 | 5783 | 1 | 10 | 42 | |
| GSE60625 | PTPN13 | 5783 | 0 | 0 | 11 | |
| GSE74703 | PTPN13 | 5783 | 0 | 11 | 25 | |
| GSE74704 | PTPN13 | 5783 | 2 | 7 | 11 | |
| TCGA | PTPN13 | 5783 | 11 | 36 | 49 |
Total number of gains: 30; Total number of losses: 156; Total Number of normals: 302.
Somatic mutations of PTPN13:
Generating mutation plots.
Highly correlated genes for PTPN13:
Showing top 20/913 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN13 | B4GALT5 | 0.809715 | 3 | 0 | 3 |
| PTPN13 | ASPG | 0.743892 | 3 | 0 | 3 |
| PTPN13 | ACTR6 | 0.736846 | 3 | 0 | 3 |
| PTPN13 | FRS2 | 0.72894 | 3 | 0 | 3 |
| PTPN13 | EPGN | 0.714249 | 3 | 0 | 3 |
| PTPN13 | CPT2 | 0.712939 | 3 | 0 | 3 |
| PTPN13 | KIF21A | 0.702196 | 3 | 0 | 3 |
| PTPN13 | SCD | 0.70102 | 3 | 0 | 3 |
| PTPN13 | PRMT6 | 0.697778 | 3 | 0 | 3 |
| PTPN13 | WDR77 | 0.695554 | 3 | 0 | 3 |
| PTPN13 | DDI2 | 0.692379 | 3 | 0 | 3 |
| PTPN13 | KPNA4 | 0.690706 | 3 | 0 | 3 |
| PTPN13 | RWDD4 | 0.690403 | 3 | 0 | 3 |
| PTPN13 | MED14 | 0.686482 | 4 | 0 | 4 |
| PTPN13 | SEC11C | 0.686392 | 3 | 0 | 3 |
| PTPN13 | PEX2 | 0.685658 | 4 | 0 | 4 |
| PTPN13 | CCND1 | 0.684662 | 3 | 0 | 3 |
| PTPN13 | PGM2 | 0.682923 | 7 | 0 | 6 |
| PTPN13 | CD1E | 0.681631 | 3 | 0 | 3 |
| PTPN13 | SERPINB12 | 0.678184 | 3 | 0 | 3 |
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