PIK3CB

 

Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Alias Symbol: 
Type: protein-coding gene Cytoband: 3q22.3
Entrez ID: 5291 HGNC ID: HGNC:8976 Ensembl Gene: ENSG00000051382 OMIM ID: 602925
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 33/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PIK3CB involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04960Aldosterone-regulated sodium reabsorption
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PIK3CB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PIK3CB 5291 212688_at -0.0466 0.9508
GSE20347 PIK3CB 5291 212688_at -0.1268 0.6069
GSE23400 PIK3CB 5291 212688_at 0.0397 0.6917
GSE26886 PIK3CB 5291 212688_at -0.4193 0.0723
GSE29001 PIK3CB 5291 212688_at 0.0556 0.8811
GSE38129 PIK3CB 5291 212688_at -0.1535 0.3970
GSE45670 PIK3CB 5291 212688_at -0.0278 0.9009
GSE53622 PIK3CB 5291 47856 0.0582 0.5566
GSE53624 PIK3CB 5291 47856 -0.0267 0.6752
GSE63941 PIK3CB 5291 212688_at 0.9796 0.0080
GSE77861 PIK3CB 5291 212688_at -0.5064 0.1250
GSE97050 PIK3CB 5291 A_23_P346969 0.4162 0.2151
SRP007169 PIK3CB 5291 RNAseq 0.5947 0.1463
SRP008496 PIK3CB 5291 RNAseq 0.3116 0.2249
SRP064894 PIK3CB 5291 RNAseq -0.2025 0.2428
SRP133303 PIK3CB 5291 RNAseq 0.1814 0.1459
SRP159526 PIK3CB 5291 RNAseq 0.2378 0.5172
SRP193095 PIK3CB 5291 RNAseq -0.0690 0.5125
SRP219564 PIK3CB 5291 RNAseq -0.3750 0.1731
TCGA PIK3CB 5291 RNAseq 0.0070 0.9022

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PIK3CB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PIK3CB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PIK3CB 5291 17 0 13
GSE20123 PIK3CB 5291 17 0 13
GSE43470 PIK3CB 5291 22 0 21
GSE46452 PIK3CB 5291 15 4 40
GSE47630 PIK3CB 5291 18 3 19
GSE54993 PIK3CB 5291 2 8 60
GSE54994 PIK3CB 5291 32 1 20
GSE60625 PIK3CB 5291 0 6 5
GSE74703 PIK3CB 5291 19 0 17
GSE74704 PIK3CB 5291 11 0 9
TCGA PIK3CB 5291 62 4 30

Total number of gains: 215; Total number of losses: 26; Total Number of normals: 247.  

 

Somatic mutations of PIK3CB:

 

Generating mutation plots.

 

Highly correlated genes for PIK3CB:

 

Showing top 20/431 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PIK3CBCSTF2T0.827609303
PIK3CBTMEM120A0.807836303
PIK3CBTMBIM60.794423303
PIK3CBLCOR0.763106303
PIK3CBPANK10.76054303
PIK3CBNFKB10.753114303
PIK3CBGLUD10.746465303
PIK3CBRHBDD10.744983303
PIK3CBARL60.736734404
PIK3CBC2CD20.735132404
PIK3CBWDR770.734249404
PIK3CBELF20.73008404
PIK3CBLRRC470.728354403
PIK3CBTHAP10.727212303
PIK3CBTHAP20.723412303
PIK3CBATG4C0.722898303
PIK3CBEIF2B10.722331403
PIK3CBMRPS18A0.720995303
PIK3CBZBED50.718415303
PIK3CBRBM40.717872303

For details and further investigation, click here