| Full name: activating signal cointegrator 1 complex subunit 1 | Alias Symbol: CGI-18|ASC1p50|Em:AC022392.3|p50 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 51008 | HGNC ID: HGNC:24268 | Ensembl Gene: ENSG00000138303 | OMIM ID: 614215 |
| Drug and gene relationship at DGIdb | |||
Expression of ASCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASCC1 | 51008 | 1554627_a_at | 0.0132 | 0.9890 | |
| GSE20347 | ASCC1 | 51008 | 219336_s_at | 0.3058 | 0.1605 | |
| GSE23400 | ASCC1 | 51008 | 219336_s_at | 0.2230 | 0.0000 | |
| GSE26886 | ASCC1 | 51008 | 219336_s_at | 0.1794 | 0.3439 | |
| GSE29001 | ASCC1 | 51008 | 219336_s_at | 0.1976 | 0.4691 | |
| GSE38129 | ASCC1 | 51008 | 219336_s_at | 0.3597 | 0.0646 | |
| GSE45670 | ASCC1 | 51008 | 1554627_a_at | 0.2643 | 0.1465 | |
| GSE53622 | ASCC1 | 51008 | 63532 | 0.3160 | 0.0000 | |
| GSE53624 | ASCC1 | 51008 | 63532 | 0.4076 | 0.0000 | |
| GSE63941 | ASCC1 | 51008 | 1554627_a_at | 1.3148 | 0.0029 | |
| GSE77861 | ASCC1 | 51008 | 1554627_a_at | 0.2382 | 0.4151 | |
| GSE97050 | ASCC1 | 51008 | A_23_P1280 | 0.3209 | 0.2494 | |
| SRP007169 | ASCC1 | 51008 | RNAseq | 0.6518 | 0.1139 | |
| SRP008496 | ASCC1 | 51008 | RNAseq | 0.8851 | 0.0055 | |
| SRP064894 | ASCC1 | 51008 | RNAseq | 0.1087 | 0.4394 | |
| SRP133303 | ASCC1 | 51008 | RNAseq | 0.2750 | 0.0178 | |
| SRP159526 | ASCC1 | 51008 | RNAseq | 0.2689 | 0.3443 | |
| SRP193095 | ASCC1 | 51008 | RNAseq | 0.1658 | 0.0201 | |
| SRP219564 | ASCC1 | 51008 | RNAseq | -0.1063 | 0.5963 | |
| TCGA | ASCC1 | 51008 | RNAseq | 0.0747 | 0.1757 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ASCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASCC1 | 51008 | 3 | 4 | 23 | |
| GSE20123 | ASCC1 | 51008 | 3 | 3 | 24 | |
| GSE43470 | ASCC1 | 51008 | 1 | 8 | 34 | |
| GSE46452 | ASCC1 | 51008 | 0 | 11 | 48 | |
| GSE47630 | ASCC1 | 51008 | 2 | 14 | 24 | |
| GSE54993 | ASCC1 | 51008 | 7 | 0 | 63 | |
| GSE54994 | ASCC1 | 51008 | 2 | 11 | 40 | |
| GSE60625 | ASCC1 | 51008 | 0 | 0 | 11 | |
| GSE74703 | ASCC1 | 51008 | 1 | 5 | 30 | |
| GSE74704 | ASCC1 | 51008 | 2 | 1 | 17 | |
| TCGA | ASCC1 | 51008 | 11 | 23 | 62 |
Total number of gains: 32; Total number of losses: 80; Total Number of normals: 376.
Somatic mutations of ASCC1:
Generating mutation plots.
Highly correlated genes for ASCC1:
Showing top 20/808 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASCC1 | TCEANC2 | 0.803312 | 3 | 0 | 3 |
| ASCC1 | ALDOC | 0.766077 | 3 | 0 | 3 |
| ASCC1 | HAUS1 | 0.75197 | 3 | 0 | 3 |
| ASCC1 | UEVLD | 0.748211 | 3 | 0 | 3 |
| ASCC1 | SMARCAD1 | 0.740598 | 3 | 0 | 3 |
| ASCC1 | CD2BP2 | 0.73865 | 3 | 0 | 3 |
| ASCC1 | AFTPH | 0.738396 | 3 | 0 | 3 |
| ASCC1 | NAA30 | 0.734435 | 3 | 0 | 3 |
| ASCC1 | SNAPC2 | 0.726061 | 3 | 0 | 3 |
| ASCC1 | SORL1 | 0.722907 | 4 | 0 | 4 |
| ASCC1 | TLR1 | 0.717186 | 3 | 0 | 3 |
| ASCC1 | REL | 0.715131 | 3 | 0 | 3 |
| ASCC1 | C12orf66 | 0.711458 | 3 | 0 | 3 |
| ASCC1 | CYB5RL | 0.707284 | 3 | 0 | 3 |
| ASCC1 | CWF19L1 | 0.705539 | 6 | 0 | 6 |
| ASCC1 | CALCRL | 0.702998 | 4 | 0 | 3 |
| ASCC1 | CGRRF1 | 0.702538 | 3 | 0 | 3 |
| ASCC1 | NFKB1 | 0.70231 | 4 | 0 | 3 |
| ASCC1 | DDX50 | 0.699934 | 9 | 0 | 8 |
| ASCC1 | CD109 | 0.69727 | 3 | 0 | 3 |
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