| Full name: DExD-box helicase 50 | Alias Symbol: GU2|MGC3199|GUB|RH-II/GuB | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 79009 | HGNC ID: HGNC:17906 | Ensembl Gene: ENSG00000107625 | OMIM ID: 610373 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX50:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX50 | 79009 | 221699_s_at | -0.0011 | 0.9985 | |
| GSE20347 | DDX50 | 79009 | 221699_s_at | 0.3265 | 0.0200 | |
| GSE23400 | DDX50 | 79009 | 221699_s_at | 0.4092 | 0.0000 | |
| GSE26886 | DDX50 | 79009 | 221699_s_at | -0.1924 | 0.3815 | |
| GSE29001 | DDX50 | 79009 | 221699_s_at | 0.2653 | 0.2672 | |
| GSE38129 | DDX50 | 79009 | 221699_s_at | 0.2213 | 0.0534 | |
| GSE45670 | DDX50 | 79009 | 221699_s_at | -0.1554 | 0.2203 | |
| GSE63941 | DDX50 | 79009 | 221699_s_at | 0.0359 | 0.9275 | |
| GSE77861 | DDX50 | 79009 | 221699_s_at | 0.0438 | 0.9026 | |
| GSE97050 | DDX50 | 79009 | A_24_P512054 | -0.0184 | 0.9369 | |
| SRP007169 | DDX50 | 79009 | RNAseq | 0.1360 | 0.7168 | |
| SRP008496 | DDX50 | 79009 | RNAseq | 0.5324 | 0.0240 | |
| SRP064894 | DDX50 | 79009 | RNAseq | -0.1018 | 0.3895 | |
| SRP133303 | DDX50 | 79009 | RNAseq | 0.3122 | 0.0172 | |
| SRP159526 | DDX50 | 79009 | RNAseq | -0.1500 | 0.5514 | |
| SRP193095 | DDX50 | 79009 | RNAseq | -0.0190 | 0.8530 | |
| SRP219564 | DDX50 | 79009 | RNAseq | -0.0146 | 0.9600 | |
| TCGA | DDX50 | 79009 | RNAseq | 0.0627 | 0.2314 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX50 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DDX50:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX50 | 79009 | 3 | 4 | 23 | |
| GSE20123 | DDX50 | 79009 | 3 | 3 | 24 | |
| GSE43470 | DDX50 | 79009 | 1 | 8 | 34 | |
| GSE46452 | DDX50 | 79009 | 0 | 11 | 48 | |
| GSE47630 | DDX50 | 79009 | 2 | 14 | 24 | |
| GSE54993 | DDX50 | 79009 | 8 | 0 | 62 | |
| GSE54994 | DDX50 | 79009 | 2 | 12 | 39 | |
| GSE60625 | DDX50 | 79009 | 0 | 0 | 11 | |
| GSE74703 | DDX50 | 79009 | 1 | 5 | 30 | |
| GSE74704 | DDX50 | 79009 | 1 | 1 | 18 | |
| TCGA | DDX50 | 79009 | 10 | 22 | 64 |
Total number of gains: 31; Total number of losses: 80; Total Number of normals: 377.
Somatic mutations of DDX50:
Generating mutation plots.
Highly correlated genes for DDX50:
Showing top 20/903 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX50 | SAMM50 | 0.767754 | 3 | 0 | 3 |
| DDX50 | ZNF564 | 0.765208 | 3 | 0 | 3 |
| DDX50 | TXNDC16 | 0.763573 | 3 | 0 | 3 |
| DDX50 | ZNF304 | 0.758478 | 3 | 0 | 3 |
| DDX50 | PDK3 | 0.744782 | 3 | 0 | 3 |
| DDX50 | HSF2 | 0.739726 | 6 | 0 | 6 |
| DDX50 | ZFP37 | 0.728532 | 3 | 0 | 3 |
| DDX50 | ZZZ3 | 0.718839 | 5 | 0 | 5 |
| DDX50 | GIN1 | 0.717257 | 3 | 0 | 3 |
| DDX50 | EPS8 | 0.715957 | 3 | 0 | 3 |
| DDX50 | BTAF1 | 0.714116 | 3 | 0 | 3 |
| DDX50 | ELAVL1 | 0.712506 | 6 | 0 | 6 |
| DDX50 | METTL14 | 0.710076 | 3 | 0 | 3 |
| DDX50 | SPATA6 | 0.707721 | 4 | 0 | 4 |
| DDX50 | PSME4 | 0.701953 | 3 | 0 | 3 |
| DDX50 | ZNF644 | 0.700871 | 3 | 0 | 3 |
| DDX50 | ASCC1 | 0.699934 | 9 | 0 | 8 |
| DDX50 | ZNF664 | 0.695063 | 4 | 0 | 3 |
| DDX50 | CRLS1 | 0.693971 | 3 | 0 | 3 |
| DDX50 | EPC1 | 0.683504 | 4 | 0 | 3 |
For details and further investigation, click here
