| Full name: REL proto-oncogene, NF-kB subunit | Alias Symbol: I-Rel|c-Rel | ||
| Type: protein-coding gene | Cytoband: 2p16.1 | ||
| Entrez ID: 5966 | HGNC ID: HGNC:9954 | Ensembl Gene: ENSG00000162924 | OMIM ID: 164910 |
| Drug and gene relationship at DGIdb | |||
REL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of REL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | REL | 5966 | 235242_at | 0.9223 | 0.0288 | |
| GSE20347 | REL | 5966 | 206036_s_at | 0.3475 | 0.0390 | |
| GSE23400 | REL | 5966 | 206035_at | -0.0443 | 0.3018 | |
| GSE26886 | REL | 5966 | 228812_at | 0.3315 | 0.2403 | |
| GSE29001 | REL | 5966 | 206035_at | -0.0376 | 0.9032 | |
| GSE38129 | REL | 5966 | 206036_s_at | 0.4753 | 0.0162 | |
| GSE45670 | REL | 5966 | 235242_at | 0.5716 | 0.0008 | |
| GSE53622 | REL | 5966 | 29321 | 0.5580 | 0.0000 | |
| GSE53624 | REL | 5966 | 29321 | 0.1298 | 0.1012 | |
| GSE63941 | REL | 5966 | 235242_at | 2.1270 | 0.0009 | |
| GSE77861 | REL | 5966 | 235242_at | 0.8427 | 0.0066 | |
| GSE97050 | REL | 5966 | A_23_P56938 | 0.5532 | 0.1483 | |
| SRP007169 | REL | 5966 | RNAseq | 0.5638 | 0.1157 | |
| SRP008496 | REL | 5966 | RNAseq | 0.4965 | 0.0539 | |
| SRP064894 | REL | 5966 | RNAseq | 0.2959 | 0.2880 | |
| SRP133303 | REL | 5966 | RNAseq | 0.5769 | 0.0017 | |
| SRP159526 | REL | 5966 | RNAseq | 0.3550 | 0.1931 | |
| SRP193095 | REL | 5966 | RNAseq | 0.4187 | 0.0014 | |
| SRP219564 | REL | 5966 | RNAseq | 0.7277 | 0.1583 | |
| TCGA | REL | 5966 | RNAseq | 0.2754 | 0.0043 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by REL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of REL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | REL | 5966 | 12 | 0 | 18 | |
| GSE20123 | REL | 5966 | 11 | 0 | 19 | |
| GSE43470 | REL | 5966 | 7 | 0 | 36 | |
| GSE46452 | REL | 5966 | 2 | 3 | 54 | |
| GSE47630 | REL | 5966 | 8 | 0 | 32 | |
| GSE54993 | REL | 5966 | 0 | 6 | 64 | |
| GSE54994 | REL | 5966 | 12 | 0 | 41 | |
| GSE60625 | REL | 5966 | 0 | 3 | 8 | |
| GSE74703 | REL | 5966 | 7 | 0 | 29 | |
| GSE74704 | REL | 5966 | 10 | 0 | 10 | |
| TCGA | REL | 5966 | 36 | 2 | 58 |
Total number of gains: 105; Total number of losses: 14; Total Number of normals: 369.
Somatic mutations of REL:
Generating mutation plots.
Highly correlated genes for REL:
Showing top 20/901 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| REL | MRPL30 | 0.775769 | 3 | 0 | 3 |
| REL | ERCC4 | 0.7563 | 3 | 0 | 3 |
| REL | TMEM170A | 0.7521 | 3 | 0 | 3 |
| REL | IRF2BPL | 0.741838 | 3 | 0 | 3 |
| REL | ZNF343 | 0.737612 | 3 | 0 | 3 |
| REL | GSR | 0.735594 | 3 | 0 | 3 |
| REL | UGGT1 | 0.734853 | 3 | 0 | 3 |
| REL | PPIF | 0.733864 | 3 | 0 | 3 |
| REL | ADAM15 | 0.732344 | 3 | 0 | 3 |
| REL | TRUB1 | 0.732189 | 3 | 0 | 3 |
| REL | YWHAG | 0.730535 | 5 | 0 | 4 |
| REL | RMI1 | 0.729734 | 4 | 0 | 4 |
| REL | CMTM4 | 0.727583 | 4 | 0 | 3 |
| REL | NUCKS1 | 0.725685 | 4 | 0 | 3 |
| REL | MIF | 0.724914 | 3 | 0 | 3 |
| REL | ASCC1 | 0.715131 | 3 | 0 | 3 |
| REL | TNRC18 | 0.712937 | 3 | 0 | 3 |
| REL | TRMT6 | 0.711283 | 4 | 0 | 3 |
| REL | LRRC39 | 0.70954 | 3 | 0 | 3 |
| REL | MARK1 | 0.702122 | 5 | 0 | 5 |
For details and further investigation, click here
