TLR1

 

Full name: toll like receptor 1 Alias Symbol: rsc786|KIAA0012|CD281
Type: protein-coding gene Cytoband: 4p14
Entrez ID: 7096 HGNC ID: HGNC:11847 Ensembl Gene: ENSG00000174125 OMIM ID: 601194
Drug and gene relationship at DGIdb

 

TLR1 involved pathways:

KEGG pathway Description View
hsa04620Toll-like receptor signaling pathway
hsa05152Tuberculosis

 

Expression of TLR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TLR1 7096 210176_at 0.0854 0.9534
GSE20347 TLR1 7096 210176_at 0.3368 0.0117
GSE23400 TLR1 7096 210176_at 0.1366 0.0083
GSE26886 TLR1 7096 210176_at 0.1116 0.8304
GSE29001 TLR1 7096 210176_at 0.6284 0.0235
GSE38129 TLR1 7096 210176_at 0.5784 0.0001
GSE45670 TLR1 7096 210176_at -0.2560 0.4412
GSE53622 TLR1 7096 75882 0.5957 0.0001
GSE53624 TLR1 7096 75882 0.5142 0.0023
GSE63941 TLR1 7096 210176_at 0.5555 0.6753
GSE77861 TLR1 7096 210176_at 0.1383 0.4400
GSE97050 TLR1 7096 A_23_P10873 0.5564 0.1670
SRP007169 TLR1 7096 RNAseq 1.3808 0.0098
SRP008496 TLR1 7096 RNAseq 1.2519 0.0010
SRP064894 TLR1 7096 RNAseq 0.6037 0.0288
SRP133303 TLR1 7096 RNAseq 0.5004 0.0402
SRP159526 TLR1 7096 RNAseq 0.5427 0.4746
SRP193095 TLR1 7096 RNAseq 0.8014 0.0006
SRP219564 TLR1 7096 RNAseq 0.4190 0.4252
TCGA TLR1 7096 RNAseq 0.3359 0.0146

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TLR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TLR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TLR1 7096 0 16 14
GSE20123 TLR1 7096 0 16 14
GSE43470 TLR1 7096 0 15 28
GSE46452 TLR1 7096 1 36 22
GSE47630 TLR1 7096 1 19 20
GSE54993 TLR1 7096 8 0 62
GSE54994 TLR1 7096 4 10 39
GSE60625 TLR1 7096 0 0 11
GSE74703 TLR1 7096 0 12 24
GSE74704 TLR1 7096 0 9 11
TCGA TLR1 7096 11 45 40

Total number of gains: 25; Total number of losses: 178; Total Number of normals: 285.  

 

Somatic mutations of TLR1:

 

Generating mutation plots.

 

Highly correlated genes for TLR1:

 

Showing top 20/712 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TLR1FCGR3A0.795317303
TLR1ZNF180.779972303
TLR1GPR1410.761438303
TLR1IL2RA0.756897404
TLR1PIGS0.749599303
TLR1C19orf380.740325303
TLR1CD2260.737736303
TLR1SLC25A50.729964303
TLR1CERKL0.729715303
TLR1TCN20.723188404
TLR1SPPL2A0.719594303
TLR1ASCC10.717186303
TLR1SAMM500.716398303
TLR1ITGAM0.709497908
TLR1FNTA0.706578303
TLR1GUCY1A20.705306303
TLR1ANPEP0.702729403
TLR1PPP1R16B0.698731404
TLR1SLFN110.697525606
TLR1DRG10.697284403

For details and further investigation, click here