NFKB1

 

Full name: nuclear factor kappa B subunit 1 Alias Symbol: KBF1|p105|NFKB-p50|p50|NF-kappaB|NFkappaB|NF-kB1
Type: protein-coding gene Cytoband: 4q24
Entrez ID: 4790 HGNC ID: HGNC:7794 Ensembl Gene: ENSG00000109320 OMIM ID: 164011
Drug and gene relationship at DGIdb
Screen Evidence:

 

NFKB1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04066HIF-1 signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04917Prolactin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05030Cocaine addiction
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of NFKB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFKB1 4790 209239_at 0.2884 0.3835
GSE20347 NFKB1 4790 209239_at -0.2226 0.0818
GSE23400 NFKB1 4790 209239_at 0.0388 0.5499
GSE26886 NFKB1 4790 209239_at -0.6293 0.0082
GSE29001 NFKB1 4790 209239_at -0.0690 0.8418
GSE38129 NFKB1 4790 209239_at -0.1793 0.1467
GSE45670 NFKB1 4790 209239_at 0.0637 0.6195
GSE53622 NFKB1 4790 107107 0.1097 0.2401
GSE53624 NFKB1 4790 107107 -0.0144 0.9170
GSE63941 NFKB1 4790 209239_at 0.3967 0.2107
GSE77861 NFKB1 4790 209239_at -0.0758 0.8063
GSE97050 NFKB1 4790 A_23_P30024 0.3806 0.2501
SRP007169 NFKB1 4790 RNAseq 0.2054 0.6062
SRP008496 NFKB1 4790 RNAseq 0.0988 0.6765
SRP064894 NFKB1 4790 RNAseq -0.0385 0.8240
SRP133303 NFKB1 4790 RNAseq 0.3636 0.0195
SRP159526 NFKB1 4790 RNAseq -0.4817 0.0478
SRP193095 NFKB1 4790 RNAseq 0.2847 0.0111
SRP219564 NFKB1 4790 RNAseq -0.0248 0.9165
TCGA NFKB1 4790 RNAseq 0.0351 0.4736

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NFKB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NFKB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFKB1 4790 1 12 17
GSE20123 NFKB1 4790 1 12 17
GSE43470 NFKB1 4790 0 13 30
GSE46452 NFKB1 4790 1 36 22
GSE47630 NFKB1 4790 0 20 20
GSE54993 NFKB1 4790 9 0 61
GSE54994 NFKB1 4790 1 10 42
GSE60625 NFKB1 4790 0 3 8
GSE74703 NFKB1 4790 0 11 25
GSE74704 NFKB1 4790 0 6 14
TCGA NFKB1 4790 8 39 49

Total number of gains: 21; Total number of losses: 162; Total Number of normals: 305.  

 

Somatic mutations of NFKB1:

 

Generating mutation plots.

 

Highly correlated genes for NFKB1:

 

Showing top 20/645 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFKB1RPP380.817774303
NFKB1PPIL30.801457303
NFKB1MAD2L20.79342303
NFKB1HSPA90.789314303
NFKB1API50.786832303
NFKB1SETD70.766313303
NFKB1NIT20.766105303
NFKB1ZNHIT10.759866303
NFKB1KLHL90.759609303
NFKB1BBS70.754921303
NFKB1PIK3CB0.753114303
NFKB1TTI20.751908403
NFKB1BIRC20.751457303
NFKB1NPAT0.745849303
NFKB1AATF0.744597303
NFKB1RNF2070.744117303
NFKB1TMEM2080.744033303
NFKB1ARPC1A0.743991404
NFKB1ADNP0.743879303
NFKB1MRPS140.741969303

For details and further investigation, click here