| Full name: potassium voltage-gated channel subfamily A member regulatory beta subunit 1 | Alias Symbol: AKR6A3|KCNA1B|hKvBeta3|Kvb1.3|hKvb3 | ||
| Type: protein-coding gene | Cytoband: 3q25.31 | ||
| Entrez ID: 7881 | HGNC ID: HGNC:6228 | Ensembl Gene: ENSG00000169282 | OMIM ID: 601141 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNAB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNAB1 | 7881 | 210078_s_at | -1.3606 | 0.0119 | |
| GSE20347 | KCNAB1 | 7881 | 210078_s_at | -0.9853 | 0.0000 | |
| GSE23400 | KCNAB1 | 7881 | 210079_x_at | -0.1119 | 0.0075 | |
| GSE26886 | KCNAB1 | 7881 | 210078_s_at | -2.9332 | 0.0000 | |
| GSE29001 | KCNAB1 | 7881 | 210078_s_at | -1.2797 | 0.0014 | |
| GSE38129 | KCNAB1 | 7881 | 210078_s_at | -1.3614 | 0.0000 | |
| GSE45670 | KCNAB1 | 7881 | 210078_s_at | -2.2035 | 0.0000 | |
| GSE53622 | KCNAB1 | 7881 | 68645 | -1.5712 | 0.0000 | |
| GSE53624 | KCNAB1 | 7881 | 68645 | -1.5480 | 0.0000 | |
| GSE63941 | KCNAB1 | 7881 | 210078_s_at | 0.7185 | 0.2468 | |
| GSE77861 | KCNAB1 | 7881 | 231524_at | -0.0023 | 0.9893 | |
| GSE97050 | KCNAB1 | 7881 | A_24_P182929 | -0.6443 | 0.1238 | |
| SRP007169 | KCNAB1 | 7881 | RNAseq | -1.1926 | 0.0221 | |
| SRP064894 | KCNAB1 | 7881 | RNAseq | -0.9430 | 0.0001 | |
| SRP133303 | KCNAB1 | 7881 | RNAseq | -0.4609 | 0.0888 | |
| SRP159526 | KCNAB1 | 7881 | RNAseq | -0.5877 | 0.1959 | |
| SRP193095 | KCNAB1 | 7881 | RNAseq | -0.0201 | 0.8963 | |
| SRP219564 | KCNAB1 | 7881 | RNAseq | -0.6018 | 0.2659 | |
| TCGA | KCNAB1 | 7881 | RNAseq | -0.7492 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by KCNAB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNAB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNAB1 | 7881 | 21 | 1 | 8 | |
| GSE20123 | KCNAB1 | 7881 | 21 | 1 | 8 | |
| GSE43470 | KCNAB1 | 7881 | 23 | 0 | 20 | |
| GSE46452 | KCNAB1 | 7881 | 18 | 2 | 39 | |
| GSE47630 | KCNAB1 | 7881 | 19 | 3 | 18 | |
| GSE54993 | KCNAB1 | 7881 | 1 | 11 | 58 | |
| GSE54994 | KCNAB1 | 7881 | 38 | 1 | 14 | |
| GSE60625 | KCNAB1 | 7881 | 0 | 6 | 5 | |
| GSE74703 | KCNAB1 | 7881 | 20 | 0 | 16 | |
| GSE74704 | KCNAB1 | 7881 | 14 | 0 | 6 | |
| TCGA | KCNAB1 | 7881 | 73 | 1 | 22 |
Total number of gains: 248; Total number of losses: 26; Total Number of normals: 214.
Somatic mutations of KCNAB1:
Generating mutation plots.
Highly correlated genes for KCNAB1:
Showing top 20/1094 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNAB1 | C1QTNF7 | 0.836914 | 5 | 0 | 5 |
| KCNAB1 | ANGPTL1 | 0.827599 | 5 | 0 | 5 |
| KCNAB1 | CLEC3B | 0.821456 | 3 | 0 | 3 |
| KCNAB1 | GGA3 | 0.80767 | 3 | 0 | 3 |
| KCNAB1 | CGNL1 | 0.796542 | 6 | 0 | 6 |
| KCNAB1 | SNORA68 | 0.792555 | 3 | 0 | 3 |
| KCNAB1 | GPD1L | 0.783892 | 9 | 0 | 9 |
| KCNAB1 | CHADL | 0.779993 | 3 | 0 | 3 |
| KCNAB1 | GPIHBP1 | 0.775452 | 3 | 0 | 3 |
| KCNAB1 | XKR4 | 0.775438 | 5 | 0 | 5 |
| KCNAB1 | SH3BGRL2 | 0.772808 | 6 | 0 | 6 |
| KCNAB1 | FHL5 | 0.769236 | 6 | 0 | 6 |
| KCNAB1 | TMEM132C | 0.768191 | 3 | 0 | 3 |
| KCNAB1 | EIF4E3 | 0.766901 | 7 | 0 | 6 |
| KCNAB1 | SORBS2 | 0.763249 | 9 | 0 | 9 |
| KCNAB1 | GBP6 | 0.75935 | 3 | 0 | 3 |
| KCNAB1 | KCTD6 | 0.758877 | 6 | 0 | 6 |
| KCNAB1 | PLCXD3 | 0.758681 | 5 | 0 | 5 |
| KCNAB1 | PAQR8 | 0.75659 | 6 | 0 | 6 |
| KCNAB1 | CTTNBP2 | 0.75633 | 5 | 0 | 5 |
For details and further investigation, click here
