| Full name: spectrin repeat containing nuclear envelope protein 2 | Alias Symbol: SYNE-2|DKFZP434H2235|Nesprin-2|NUANCE|NUA|KIAA1011|Nesp2 | ||
| Type: protein-coding gene | Cytoband: 14q23.2 | ||
| Entrez ID: 23224 | HGNC ID: HGNC:17084 | Ensembl Gene: ENSG00000054654 | OMIM ID: 608442 |
| Drug and gene relationship at DGIdb | |||
Expression of SYNE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYNE2 | 23224 | 202761_s_at | 0.0084 | 0.9908 | |
| GSE20347 | SYNE2 | 23224 | 202761_s_at | -0.3578 | 0.0435 | |
| GSE23400 | SYNE2 | 23224 | 202761_s_at | 0.2649 | 0.0111 | |
| GSE26886 | SYNE2 | 23224 | 202761_s_at | 0.6860 | 0.0041 | |
| GSE29001 | SYNE2 | 23224 | 202761_s_at | -0.0530 | 0.8876 | |
| GSE38129 | SYNE2 | 23224 | 202761_s_at | -0.0843 | 0.6647 | |
| GSE45670 | SYNE2 | 23224 | 202761_s_at | -0.0852 | 0.6300 | |
| GSE53622 | SYNE2 | 23224 | 28788 | 0.5793 | 0.0000 | |
| GSE53624 | SYNE2 | 23224 | 69850 | -0.2705 | 0.0000 | |
| GSE63941 | SYNE2 | 23224 | 202761_s_at | 3.6362 | 0.0001 | |
| GSE77861 | SYNE2 | 23224 | 202761_s_at | -0.0701 | 0.8901 | |
| GSE97050 | SYNE2 | 23224 | A_24_P68311 | 0.2668 | 0.2764 | |
| SRP007169 | SYNE2 | 23224 | RNAseq | 0.5770 | 0.1006 | |
| SRP008496 | SYNE2 | 23224 | RNAseq | 0.3144 | 0.2154 | |
| SRP064894 | SYNE2 | 23224 | RNAseq | -0.0695 | 0.7629 | |
| SRP133303 | SYNE2 | 23224 | RNAseq | -0.1043 | 0.6233 | |
| SRP159526 | SYNE2 | 23224 | RNAseq | -0.0484 | 0.9161 | |
| SRP193095 | SYNE2 | 23224 | RNAseq | 0.0802 | 0.5432 | |
| SRP219564 | SYNE2 | 23224 | RNAseq | -0.1611 | 0.6794 | |
| TCGA | SYNE2 | 23224 | RNAseq | 0.0480 | 0.3706 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SYNE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYNE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYNE2 | 23224 | 7 | 3 | 20 | |
| GSE20123 | SYNE2 | 23224 | 7 | 3 | 20 | |
| GSE43470 | SYNE2 | 23224 | 8 | 2 | 33 | |
| GSE46452 | SYNE2 | 23224 | 16 | 3 | 40 | |
| GSE47630 | SYNE2 | 23224 | 11 | 9 | 20 | |
| GSE54993 | SYNE2 | 23224 | 3 | 9 | 58 | |
| GSE54994 | SYNE2 | 23224 | 18 | 5 | 30 | |
| GSE60625 | SYNE2 | 23224 | 0 | 2 | 9 | |
| GSE74703 | SYNE2 | 23224 | 7 | 2 | 27 | |
| GSE74704 | SYNE2 | 23224 | 3 | 2 | 15 | |
| TCGA | SYNE2 | 23224 | 32 | 14 | 50 |
Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.
Somatic mutations of SYNE2:
Generating mutation plots.
Highly correlated genes for SYNE2:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYNE2 | ENSA | 0.803913 | 3 | 0 | 3 |
| SYNE2 | CNOT10 | 0.795944 | 3 | 0 | 3 |
| SYNE2 | COX15 | 0.789128 | 3 | 0 | 3 |
| SYNE2 | NSMCE4A | 0.785962 | 3 | 0 | 3 |
| SYNE2 | SUGP1 | 0.781821 | 3 | 0 | 3 |
| SYNE2 | RPA1 | 0.778383 | 3 | 0 | 3 |
| SYNE2 | EPB41L5 | 0.77006 | 3 | 0 | 3 |
| SYNE2 | REPS1 | 0.768371 | 3 | 0 | 3 |
| SYNE2 | ASH1L | 0.765759 | 3 | 0 | 3 |
| SYNE2 | UHRF1BP1 | 0.760799 | 3 | 0 | 3 |
| SYNE2 | SFMBT1 | 0.759732 | 3 | 0 | 3 |
| SYNE2 | IRX3 | 0.759108 | 3 | 0 | 3 |
| SYNE2 | RNF13 | 0.753209 | 3 | 0 | 3 |
| SYNE2 | MRPS22 | 0.752149 | 3 | 0 | 3 |
| SYNE2 | C1orf50 | 0.751319 | 3 | 0 | 3 |
| SYNE2 | HMGCS1 | 0.749731 | 3 | 0 | 3 |
| SYNE2 | MRPL3 | 0.747211 | 3 | 0 | 3 |
| SYNE2 | ZNF121 | 0.747141 | 3 | 0 | 3 |
| SYNE2 | HNRNPUL1 | 0.7414 | 3 | 0 | 3 |
| SYNE2 | GINS3 | 0.740743 | 3 | 0 | 3 |
For details and further investigation, click here
