| Full name: RUN and FYVE domain containing 3 | Alias Symbol: RIPx|KIAA0871|Singar1|ZFYVE30 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 22902 | HGNC ID: HGNC:30285 | Ensembl Gene: ENSG00000018189 | OMIM ID: 611194 |
| Drug and gene relationship at DGIdb | |||
Expression of RUFY3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RUFY3 | 22902 | 213939_s_at | -0.3229 | 0.6898 | |
| GSE20347 | RUFY3 | 22902 | 213939_s_at | -1.1162 | 0.0000 | |
| GSE23400 | RUFY3 | 22902 | 213939_s_at | -0.6231 | 0.0000 | |
| GSE26886 | RUFY3 | 22902 | 213939_s_at | -1.1489 | 0.0002 | |
| GSE29001 | RUFY3 | 22902 | 213939_s_at | -0.8937 | 0.0358 | |
| GSE38129 | RUFY3 | 22902 | 213939_s_at | -0.9742 | 0.0000 | |
| GSE45670 | RUFY3 | 22902 | 213939_s_at | -0.8197 | 0.0010 | |
| GSE63941 | RUFY3 | 22902 | 229334_at | 1.4294 | 0.0362 | |
| GSE77861 | RUFY3 | 22902 | 213939_s_at | -0.8694 | 0.0338 | |
| GSE97050 | RUFY3 | 22902 | A_24_P221575 | -0.1163 | 0.6370 | |
| SRP007169 | RUFY3 | 22902 | RNAseq | -0.4524 | 0.1970 | |
| SRP008496 | RUFY3 | 22902 | RNAseq | -0.4956 | 0.0398 | |
| SRP064894 | RUFY3 | 22902 | RNAseq | -0.8022 | 0.0000 | |
| SRP133303 | RUFY3 | 22902 | RNAseq | -0.6908 | 0.0000 | |
| SRP159526 | RUFY3 | 22902 | RNAseq | -0.9911 | 0.0044 | |
| SRP193095 | RUFY3 | 22902 | RNAseq | -1.0473 | 0.0000 | |
| SRP219564 | RUFY3 | 22902 | RNAseq | -0.9141 | 0.0073 | |
| TCGA | RUFY3 | 22902 | RNAseq | -0.1997 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by RUFY3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RUFY3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUFY3 | 22902 | 0 | 11 | 19 | |
| GSE20123 | RUFY3 | 22902 | 0 | 11 | 19 | |
| GSE43470 | RUFY3 | 22902 | 0 | 13 | 30 | |
| GSE46452 | RUFY3 | 22902 | 2 | 35 | 22 | |
| GSE47630 | RUFY3 | 22902 | 1 | 19 | 20 | |
| GSE54993 | RUFY3 | 22902 | 7 | 0 | 63 | |
| GSE54994 | RUFY3 | 22902 | 1 | 9 | 43 | |
| GSE60625 | RUFY3 | 22902 | 0 | 0 | 11 | |
| GSE74703 | RUFY3 | 22902 | 0 | 11 | 25 | |
| GSE74704 | RUFY3 | 22902 | 0 | 6 | 14 | |
| TCGA | RUFY3 | 22902 | 16 | 28 | 52 |
Total number of gains: 27; Total number of losses: 143; Total Number of normals: 318.
Somatic mutations of RUFY3:
Generating mutation plots.
Highly correlated genes for RUFY3:
Showing top 20/936 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUFY3 | MPHOSPH10 | 0.805603 | 3 | 0 | 3 |
| RUFY3 | TAB3 | 0.786479 | 4 | 0 | 4 |
| RUFY3 | PLEKHH1 | 0.782682 | 3 | 0 | 3 |
| RUFY3 | GPBP1 | 0.770389 | 3 | 0 | 3 |
| RUFY3 | ASH1L | 0.764665 | 3 | 0 | 3 |
| RUFY3 | STRADB | 0.758869 | 5 | 0 | 5 |
| RUFY3 | CGNL1 | 0.753555 | 4 | 0 | 4 |
| RUFY3 | FCHO2 | 0.752758 | 4 | 0 | 4 |
| RUFY3 | NAA15 | 0.747881 | 3 | 0 | 3 |
| RUFY3 | TIFA | 0.74785 | 4 | 0 | 4 |
| RUFY3 | TMPRSS11B | 0.744962 | 3 | 0 | 3 |
| RUFY3 | RBM20 | 0.735758 | 5 | 0 | 5 |
| RUFY3 | SPPL3 | 0.732329 | 3 | 0 | 3 |
| RUFY3 | SNAPC3 | 0.729248 | 4 | 0 | 4 |
| RUFY3 | C15orf62 | 0.72823 | 4 | 0 | 4 |
| RUFY3 | ZNF823 | 0.727237 | 4 | 0 | 4 |
| RUFY3 | PKN2 | 0.725485 | 7 | 0 | 7 |
| RUFY3 | HSBP1L1 | 0.724584 | 4 | 0 | 4 |
| RUFY3 | MPP7 | 0.724209 | 5 | 0 | 5 |
| RUFY3 | CCDC84 | 0.723974 | 3 | 0 | 3 |
For details and further investigation, click here
