AXIN1

 

Full name: axin 1 Alias Symbol: PPP1R49
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 8312 HGNC ID: HGNC:903 Ensembl Gene: ENSG00000103126 OMIM ID: 603816
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

AXIN1 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa05213Endometrial cancer

 

Expression of AXIN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AXIN1 8312 212849_at 0.6388 0.1299
GSE20347 AXIN1 8312 212849_at 0.2512 0.0037
GSE23400 AXIN1 8312 212849_at 0.1066 0.0270
GSE26886 AXIN1 8312 212849_at 0.1642 0.3764
GSE29001 AXIN1 8312 212849_at 0.0535 0.7348
GSE38129 AXIN1 8312 212849_at 0.1603 0.0196
GSE45670 AXIN1 8312 212849_at 0.2440 0.0022
GSE53622 AXIN1 8312 28386 0.0920 0.2732
GSE53624 AXIN1 8312 28386 -0.3230 0.0009
GSE63941 AXIN1 8312 212849_at 0.7337 0.0047
GSE77861 AXIN1 8312 212849_at 0.2011 0.2748
GSE97050 AXIN1 8312 A_24_P22488 0.1780 0.4132
SRP007169 AXIN1 8312 RNAseq 0.2922 0.4788
SRP008496 AXIN1 8312 RNAseq 0.4865 0.1422
SRP064894 AXIN1 8312 RNAseq 0.3092 0.1137
SRP133303 AXIN1 8312 RNAseq 0.3523 0.0223
SRP159526 AXIN1 8312 RNAseq 0.3968 0.1008
SRP193095 AXIN1 8312 RNAseq 0.4544 0.0000
SRP219564 AXIN1 8312 RNAseq 0.3141 0.2980
TCGA AXIN1 8312 RNAseq 0.1400 0.0052

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by AXIN1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AXIN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AXIN1 8312 5 5 20
GSE20123 AXIN1 8312 5 4 21
GSE43470 AXIN1 8312 3 7 33
GSE46452 AXIN1 8312 38 1 20
GSE47630 AXIN1 8312 13 6 21
GSE54993 AXIN1 8312 3 5 62
GSE54994 AXIN1 8312 4 10 39
GSE60625 AXIN1 8312 4 0 7
GSE74703 AXIN1 8312 3 5 28
GSE74704 AXIN1 8312 3 2 15
TCGA AXIN1 8312 20 15 61

Total number of gains: 101; Total number of losses: 60; Total Number of normals: 327.  

 

Somatic mutations of AXIN1:

 

Generating mutation plots.

 

Highly correlated genes for AXIN1:

 

Showing top 20/332 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AXIN1TP53BP10.844376303
AXIN1CC2D1B0.779245303
AXIN1PRR150.774642303
AXIN1G6PD0.760224303
AXIN1PTCH20.725772303
AXIN1GRIN10.725606303
AXIN1PARS20.722341404
AXIN1RCC20.72084303
AXIN1EMID10.699059404
AXIN1SNORA71A0.696087403
AXIN1BTK0.695082404
AXIN1TAS2R390.691211303
AXIN1PGC0.686841303
AXIN1TNN0.68451303
AXIN1C20orf1440.680301403
AXIN1UBXN110.678209303
AXIN1FUT70.674247303
AXIN1SIGLEC70.671673403
AXIN1TBX100.668147303
AXIN1WDR900.667573503

For details and further investigation, click here