GRIN1

 

Full name: glutamate ionotropic receptor NMDA type subunit 1 Alias Symbol: GluN1
Type: protein-coding gene Cytoband: 9q34.3
Entrez ID: 2902 HGNC ID: HGNC:4584 Ensembl Gene: ENSG00000176884 OMIM ID: 138249
Drug and gene relationship at DGIdb

 

GRIN1 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04724Glutamatergic synapse
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism

 

Expression of GRIN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GRIN1 2902 210782_x_at -0.0542 0.8584
GSE20347 GRIN1 2902 210782_x_at -0.1125 0.1300
GSE23400 GRIN1 2902 210781_x_at -0.1907 0.0000
GSE26886 GRIN1 2902 210782_x_at 0.3259 0.0100
GSE29001 GRIN1 2902 211125_x_at -0.1801 0.3248
GSE38129 GRIN1 2902 210782_x_at -0.2096 0.0050
GSE45670 GRIN1 2902 210782_x_at -0.0308 0.7461
GSE53622 GRIN1 2902 93421 0.0841 0.3404
GSE53624 GRIN1 2902 93421 0.2676 0.0000
GSE63941 GRIN1 2902 210782_x_at -0.1218 0.3854
GSE77861 GRIN1 2902 210782_x_at -0.0630 0.7729
GSE97050 GRIN1 2902 A_23_P257962 -0.0273 0.9096
SRP133303 GRIN1 2902 RNAseq -1.1369 0.0487
SRP159526 GRIN1 2902 RNAseq 1.4176 0.0655
SRP219564 GRIN1 2902 RNAseq -1.4738 0.0430
TCGA GRIN1 2902 RNAseq -0.5541 0.1265

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by GRIN1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GRIN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GRIN1 2902 5 7 18
GSE20123 GRIN1 2902 5 7 18
GSE43470 GRIN1 2902 3 7 33
GSE46452 GRIN1 2902 6 13 40
GSE47630 GRIN1 2902 6 15 19
GSE54993 GRIN1 2902 3 3 64
GSE54994 GRIN1 2902 12 8 33
GSE60625 GRIN1 2902 0 0 11
GSE74703 GRIN1 2902 3 5 28
GSE74704 GRIN1 2902 3 5 12
TCGA GRIN1 2902 29 23 44

Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.  

 

Somatic mutations of GRIN1:

 

Generating mutation plots.

 

Highly correlated genes for GRIN1:

 

Showing top 20/919 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GRIN1GPC20.811243303
GRIN1RALYL0.800797303
GRIN1MGAT5B0.783773303
GRIN1UFSP10.779723303
GRIN1DOK70.774341303
GRIN1STK32C0.772888303
GRIN1FBLL10.771319303
GRIN1C19orf810.770137303
GRIN1WDR900.763534303
GRIN1JSRP10.751931404
GRIN1SCGN0.748772504
GRIN1TLR80.748158303
GRIN1LINC004750.74616303
GRIN1LINC005140.742063303
GRIN1WDR780.738114303
GRIN1GPD10.732595404
GRIN1ACR0.729185505
GRIN1HSD3B10.726476404
GRIN1AMBN0.725976404
GRIN1LRRC460.725794303

For details and further investigation, click here