| Full name: Bruton tyrosine kinase | Alias Symbol: ATK|XLA|PSCTK1 | ||
| Type: protein-coding gene | Cytoband: Xq22.1 | ||
| Entrez ID: 695 | HGNC ID: HGNC:1133 | Ensembl Gene: ENSG00000010671 | OMIM ID: 300300 |
| Drug and gene relationship at DGIdb | |||
BTK involved pathways:
Expression of BTK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BTK | 695 | 205504_at | 0.1593 | 0.8197 | |
| GSE20347 | BTK | 695 | 205504_at | -0.0052 | 0.9686 | |
| GSE23400 | BTK | 695 | 205504_at | -0.0358 | 0.3897 | |
| GSE26886 | BTK | 695 | 205504_at | 0.1560 | 0.3480 | |
| GSE29001 | BTK | 695 | 205504_at | 0.1219 | 0.6571 | |
| GSE38129 | BTK | 695 | 205504_at | -0.0753 | 0.7043 | |
| GSE45670 | BTK | 695 | 205504_at | -0.2015 | 0.4531 | |
| GSE53622 | BTK | 695 | 89443 | -0.0826 | 0.0621 | |
| GSE53624 | BTK | 695 | 32464 | -0.1845 | 0.0008 | |
| GSE63941 | BTK | 695 | 205504_at | 0.3340 | 0.0226 | |
| GSE77861 | BTK | 695 | 205504_at | 0.0229 | 0.8486 | |
| GSE97050 | BTK | 695 | A_33_P3277514 | 0.2533 | 0.3508 | |
| SRP007169 | BTK | 695 | RNAseq | 0.8332 | 0.3384 | |
| SRP064894 | BTK | 695 | RNAseq | 0.5164 | 0.0912 | |
| SRP133303 | BTK | 695 | RNAseq | -0.2720 | 0.3287 | |
| SRP159526 | BTK | 695 | RNAseq | -0.7266 | 0.3920 | |
| SRP193095 | BTK | 695 | RNAseq | 0.2192 | 0.4357 | |
| SRP219564 | BTK | 695 | RNAseq | 0.7008 | 0.1104 | |
| TCGA | BTK | 695 | RNAseq | -0.1417 | 0.5155 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BTK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BTK:
No record found for this gene.
Somatic mutations of BTK:
Generating mutation plots.
Highly correlated genes for BTK:
Showing top 20/257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BTK | NUDT13 | 0.76349 | 3 | 0 | 3 |
| BTK | SIRPD | 0.748882 | 3 | 0 | 3 |
| BTK | ESPNL | 0.745263 | 3 | 0 | 3 |
| BTK | SPN | 0.744992 | 3 | 0 | 3 |
| BTK | CSF2RB | 0.728026 | 4 | 0 | 4 |
| BTK | CD27 | 0.727006 | 7 | 0 | 6 |
| BTK | FGD5 | 0.71457 | 4 | 0 | 4 |
| BTK | IL10RA | 0.714264 | 8 | 0 | 6 |
| BTK | POM121L12 | 0.711888 | 3 | 0 | 3 |
| BTK | RNF144A-AS1 | 0.70952 | 3 | 0 | 3 |
| BTK | PRSS38 | 0.709067 | 3 | 0 | 3 |
| BTK | SP6 | 0.708544 | 4 | 0 | 4 |
| BTK | BMF | 0.700236 | 4 | 0 | 4 |
| BTK | AXIN1 | 0.695082 | 4 | 0 | 4 |
| BTK | NLRC3 | 0.692939 | 4 | 0 | 4 |
| BTK | NLRP5 | 0.692932 | 3 | 0 | 3 |
| BTK | LINC01215 | 0.692016 | 3 | 0 | 3 |
| BTK | CYTIP | 0.691466 | 5 | 0 | 4 |
| BTK | CD48 | 0.689421 | 8 | 0 | 6 |
| BTK | ZNF687 | 0.686568 | 3 | 0 | 3 |
For details and further investigation, click here
