| Full name: bridging integrator 2 | Alias Symbol: BRAP-1 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 51411 | HGNC ID: HGNC:1053 | Ensembl Gene: ENSG00000110934 | OMIM ID: 605936 |
| Drug and gene relationship at DGIdb | |||
Expression of BIN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BIN2 | 51411 | 219191_s_at | 0.1211 | 0.9044 | |
| GSE20347 | BIN2 | 51411 | 219191_s_at | 0.0074 | 0.9581 | |
| GSE23400 | BIN2 | 51411 | 219191_s_at | -0.0349 | 0.4931 | |
| GSE26886 | BIN2 | 51411 | 219191_s_at | -0.1519 | 0.4692 | |
| GSE29001 | BIN2 | 51411 | 219191_s_at | -0.1092 | 0.4510 | |
| GSE38129 | BIN2 | 51411 | 219191_s_at | -0.1123 | 0.4386 | |
| GSE45670 | BIN2 | 51411 | 219191_s_at | -0.0140 | 0.9651 | |
| GSE53622 | BIN2 | 51411 | 18350 | 0.0297 | 0.8619 | |
| GSE53624 | BIN2 | 51411 | 18350 | -0.2925 | 0.0550 | |
| GSE63941 | BIN2 | 51411 | 219191_s_at | 0.0740 | 0.7191 | |
| GSE77861 | BIN2 | 51411 | 219191_s_at | -0.0212 | 0.8739 | |
| GSE97050 | BIN2 | 51411 | A_23_P162386 | 0.5796 | 0.1163 | |
| SRP007169 | BIN2 | 51411 | RNAseq | 1.5370 | 0.0774 | |
| SRP064894 | BIN2 | 51411 | RNAseq | 0.4835 | 0.0751 | |
| SRP133303 | BIN2 | 51411 | RNAseq | -0.0260 | 0.8884 | |
| SRP159526 | BIN2 | 51411 | RNAseq | -0.2490 | 0.7514 | |
| SRP193095 | BIN2 | 51411 | RNAseq | 0.3196 | 0.1676 | |
| SRP219564 | BIN2 | 51411 | RNAseq | 0.6036 | 0.1614 | |
| TCGA | BIN2 | 51411 | RNAseq | 0.1646 | 0.3331 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BIN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BIN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BIN2 | 51411 | 8 | 1 | 21 | |
| GSE20123 | BIN2 | 51411 | 8 | 1 | 21 | |
| GSE43470 | BIN2 | 51411 | 4 | 0 | 39 | |
| GSE46452 | BIN2 | 51411 | 8 | 1 | 50 | |
| GSE47630 | BIN2 | 51411 | 11 | 2 | 27 | |
| GSE54993 | BIN2 | 51411 | 0 | 5 | 65 | |
| GSE54994 | BIN2 | 51411 | 3 | 2 | 48 | |
| GSE60625 | BIN2 | 51411 | 0 | 0 | 11 | |
| GSE74703 | BIN2 | 51411 | 3 | 0 | 33 | |
| GSE74704 | BIN2 | 51411 | 5 | 1 | 14 | |
| TCGA | BIN2 | 51411 | 14 | 11 | 71 |
Total number of gains: 64; Total number of losses: 24; Total Number of normals: 400.
Somatic mutations of BIN2:
Generating mutation plots.
Highly correlated genes for BIN2:
Showing top 20/475 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BIN2 | ARHGAP9 | 0.899888 | 5 | 0 | 5 |
| BIN2 | SNX20 | 0.876605 | 5 | 0 | 5 |
| BIN2 | TAGAP | 0.86851 | 4 | 0 | 4 |
| BIN2 | PREX1 | 0.860113 | 3 | 0 | 3 |
| BIN2 | TNFAIP8L2 | 0.829322 | 6 | 0 | 6 |
| BIN2 | P2RY8 | 0.817109 | 3 | 0 | 3 |
| BIN2 | PARVG | 0.801518 | 6 | 0 | 5 |
| BIN2 | ARHGAP15 | 0.785418 | 3 | 0 | 3 |
| BIN2 | C19orf38 | 0.784605 | 3 | 0 | 3 |
| BIN2 | GIMAP5 | 0.783434 | 3 | 0 | 3 |
| BIN2 | SAMD3 | 0.781616 | 5 | 0 | 5 |
| BIN2 | NCKAP1L | 0.771114 | 9 | 0 | 8 |
| BIN2 | PTPN7 | 0.746734 | 10 | 0 | 10 |
| BIN2 | RBP5 | 0.74143 | 4 | 0 | 4 |
| BIN2 | GRAPL | 0.741262 | 4 | 0 | 3 |
| BIN2 | C1orf162 | 0.738254 | 6 | 0 | 5 |
| BIN2 | MYO1F | 0.737991 | 10 | 0 | 9 |
| BIN2 | CR1L | 0.734151 | 4 | 0 | 4 |
| BIN2 | CORO1A | 0.733071 | 9 | 0 | 8 |
| BIN2 | CERKL | 0.727574 | 3 | 0 | 3 |
For details and further investigation, click here
