PTPN7

 

Full name: protein tyrosine phosphatase non-receptor type 7 Alias Symbol: HEPTP|LC-PTP
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 5778 HGNC ID: HGNC:9659 Ensembl Gene: ENSG00000143851 OMIM ID: 176889
Drug and gene relationship at DGIdb
Screen Evidence:

 

PTPN7 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway

 

Expression of PTPN7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTPN7 5778 204852_s_at 0.4833 0.4649
GSE20347 PTPN7 5778 204852_s_at 0.1088 0.4973
GSE23400 PTPN7 5778 204852_s_at -0.0493 0.2657
GSE26886 PTPN7 5778 204852_s_at -0.1237 0.3198
GSE29001 PTPN7 5778 204852_s_at -0.2268 0.0876
GSE38129 PTPN7 5778 204852_s_at 0.0656 0.7201
GSE45670 PTPN7 5778 204852_s_at 0.2706 0.0778
GSE53622 PTPN7 5778 25145 0.4184 0.0345
GSE53624 PTPN7 5778 51753 0.0081 0.9613
GSE63941 PTPN7 5778 204852_s_at 0.1737 0.3477
GSE77861 PTPN7 5778 204852_s_at -0.1424 0.3927
GSE97050 PTPN7 5778 A_23_P201778 0.7776 0.1502
SRP007169 PTPN7 5778 RNAseq 1.0425 0.2506
SRP064894 PTPN7 5778 RNAseq 0.4782 0.0630
SRP133303 PTPN7 5778 RNAseq 0.0215 0.9388
SRP159526 PTPN7 5778 RNAseq -0.7167 0.3798
SRP193095 PTPN7 5778 RNAseq 0.0802 0.7381
SRP219564 PTPN7 5778 RNAseq 0.8308 0.0906
TCGA PTPN7 5778 RNAseq 0.2037 0.2456

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PTPN7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTPN7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTPN7 5778 11 0 19
GSE20123 PTPN7 5778 11 0 19
GSE43470 PTPN7 5778 6 0 37
GSE46452 PTPN7 5778 3 1 55
GSE47630 PTPN7 5778 14 0 26
GSE54993 PTPN7 5778 0 6 64
GSE54994 PTPN7 5778 15 0 38
GSE60625 PTPN7 5778 0 0 11
GSE74703 PTPN7 5778 6 0 30
GSE74704 PTPN7 5778 5 0 15
TCGA PTPN7 5778 43 4 49

Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.  

 

Somatic mutations of PTPN7:

 

Generating mutation plots.

 

Highly correlated genes for PTPN7:

 

Showing top 20/403 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTPN7SCML40.795002303
PTPN7SUSD30.75436404
PTPN7SNX200.753397605
PTPN7PIK3R50.750497505
PTPN7BIN20.74673410010
PTPN7SLFNL10.74663303
PTPN7C1orf1620.74478505
PTPN7SASH30.73781009
PTPN7POU2F20.725841403
PTPN7POU2AF10.721822303
PTPN7CERKL0.721683303
PTPN7SLC43A20.721469303
PTPN7PIK3AP10.718938404
PTPN7PVRIG0.709287808
PTPN7IL2RB0.708129806
PTPN7CCR50.705638908
PTPN7HAVCR20.700212403
PTPN7CORO1A0.695851009
PTPN7CYTH40.692615908
PTPN7IL2RG0.6904311010

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