| Full name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 | Alias Symbol: KIAA1415|P-REX1 | ||
| Type: protein-coding gene | Cytoband: 20q13.13 | ||
| Entrez ID: 57580 | HGNC ID: HGNC:32594 | Ensembl Gene: ENSG00000124126 | OMIM ID: 606905 |
| Drug and gene relationship at DGIdb | |||
PREX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of PREX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PREX1 | 57580 | 224909_s_at | 0.5204 | 0.4895 | |
| GSE26886 | PREX1 | 57580 | 224925_at | 0.4450 | 0.0669 | |
| GSE45670 | PREX1 | 57580 | 224925_at | -0.3405 | 0.0874 | |
| GSE63941 | PREX1 | 57580 | 224925_at | -0.1849 | 0.7930 | |
| GSE77861 | PREX1 | 57580 | 224925_at | 0.0436 | 0.7272 | |
| GSE97050 | PREX1 | 57580 | A_23_P413641 | 0.4386 | 0.1888 | |
| SRP007169 | PREX1 | 57580 | RNAseq | 1.8480 | 0.0041 | |
| SRP008496 | PREX1 | 57580 | RNAseq | 1.3995 | 0.0014 | |
| SRP064894 | PREX1 | 57580 | RNAseq | 0.4303 | 0.1042 | |
| SRP133303 | PREX1 | 57580 | RNAseq | -0.0572 | 0.7331 | |
| SRP159526 | PREX1 | 57580 | RNAseq | -0.1516 | 0.7794 | |
| SRP193095 | PREX1 | 57580 | RNAseq | 0.6388 | 0.0073 | |
| SRP219564 | PREX1 | 57580 | RNAseq | 0.6655 | 0.0314 | |
| TCGA | PREX1 | 57580 | RNAseq | -0.3387 | 0.0009 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PREX1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PREX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PREX1 | 57580 | 16 | 2 | 12 | |
| GSE20123 | PREX1 | 57580 | 16 | 2 | 12 | |
| GSE43470 | PREX1 | 57580 | 11 | 1 | 31 | |
| GSE46452 | PREX1 | 57580 | 29 | 0 | 30 | |
| GSE47630 | PREX1 | 57580 | 24 | 1 | 15 | |
| GSE54993 | PREX1 | 57580 | 0 | 18 | 52 | |
| GSE54994 | PREX1 | 57580 | 26 | 0 | 27 | |
| GSE60625 | PREX1 | 57580 | 0 | 0 | 11 | |
| GSE74703 | PREX1 | 57580 | 9 | 1 | 26 | |
| GSE74704 | PREX1 | 57580 | 12 | 0 | 8 | |
| TCGA | PREX1 | 57580 | 46 | 3 | 47 |
Total number of gains: 189; Total number of losses: 28; Total Number of normals: 271.
Somatic mutations of PREX1:
Generating mutation plots.
Highly correlated genes for PREX1:
Showing top 20/430 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PREX1 | BIN2 | 0.860113 | 3 | 0 | 3 |
| PREX1 | APBB1IP | 0.854922 | 4 | 0 | 4 |
| PREX1 | SNX20 | 0.827664 | 3 | 0 | 3 |
| PREX1 | PSMB10 | 0.823784 | 3 | 0 | 3 |
| PREX1 | LITAF | 0.820176 | 3 | 0 | 3 |
| PREX1 | PSTPIP2 | 0.819884 | 3 | 0 | 3 |
| PREX1 | RCN1 | 0.818155 | 3 | 0 | 3 |
| PREX1 | PIK3R5 | 0.816187 | 3 | 0 | 3 |
| PREX1 | RUNX3 | 0.810101 | 3 | 0 | 3 |
| PREX1 | ZAP70 | 0.783969 | 3 | 0 | 3 |
| PREX1 | APOBEC3C | 0.783185 | 3 | 0 | 3 |
| PREX1 | STK4 | 0.78216 | 3 | 0 | 3 |
| PREX1 | CTSH | 0.779135 | 3 | 0 | 3 |
| PREX1 | SELPLG | 0.775391 | 5 | 0 | 5 |
| PREX1 | RAC2 | 0.771095 | 3 | 0 | 3 |
| PREX1 | MAN2B1 | 0.7695 | 3 | 0 | 3 |
| PREX1 | SAMD3 | 0.769444 | 3 | 0 | 3 |
| PREX1 | TNFRSF9 | 0.767394 | 3 | 0 | 3 |
| PREX1 | P2RX4 | 0.765859 | 3 | 0 | 3 |
| PREX1 | ZBED1 | 0.762655 | 3 | 0 | 3 |
For details and further investigation, click here
