NCKAP1L

 

Full name: NCK associated protein 1 like Alias Symbol: 
Type: protein-coding gene Cytoband: 12q13.13-q13.2
Entrez ID: 3071 HGNC ID: HGNC:4862 Ensembl Gene: ENSG00000123338 OMIM ID: 141180
Drug and gene relationship at DGIdb

 

NCKAP1L involved pathways:

KEGG pathway Description View
hsa04810Regulation of actin cytoskeleton

 

Expression of NCKAP1L:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NCKAP1L 3071 209734_at 0.2725 0.7944
GSE20347 NCKAP1L 3071 217549_at 0.1065 0.4482
GSE23400 NCKAP1L 3071 209734_at 0.0337 0.5500
GSE26886 NCKAP1L 3071 217549_at 0.1744 0.1743
GSE29001 NCKAP1L 3071 209734_at -0.0135 0.9393
GSE38129 NCKAP1L 3071 209734_at 0.0496 0.8245
GSE45670 NCKAP1L 3071 209734_at 0.0898 0.6748
GSE53622 NCKAP1L 3071 48226 0.0201 0.9216
GSE53624 NCKAP1L 3071 48226 -0.1214 0.4991
GSE63941 NCKAP1L 3071 217549_at 0.1234 0.4991
GSE77861 NCKAP1L 3071 209734_at -0.0240 0.8689
GSE97050 NCKAP1L 3071 A_23_P128201 0.4696 0.1763
SRP007169 NCKAP1L 3071 RNAseq 1.3278 0.0949
SRP008496 NCKAP1L 3071 RNAseq 0.7360 0.1040
SRP064894 NCKAP1L 3071 RNAseq 0.2789 0.3935
SRP133303 NCKAP1L 3071 RNAseq -0.0843 0.6976
SRP159526 NCKAP1L 3071 RNAseq -0.7213 0.3910
SRP193095 NCKAP1L 3071 RNAseq 0.0729 0.7097
SRP219564 NCKAP1L 3071 RNAseq 0.3047 0.4489
TCGA NCKAP1L 3071 RNAseq -0.0392 0.7902

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NCKAP1L expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NCKAP1L:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NCKAP1L 3071 4 1 25
GSE20123 NCKAP1L 3071 4 1 25
GSE43470 NCKAP1L 3071 4 0 39
GSE46452 NCKAP1L 3071 7 1 51
GSE47630 NCKAP1L 3071 10 2 28
GSE54993 NCKAP1L 3071 0 5 65
GSE54994 NCKAP1L 3071 4 1 48
GSE60625 NCKAP1L 3071 0 0 11
GSE74703 NCKAP1L 3071 3 0 33
GSE74704 NCKAP1L 3071 3 1 16
TCGA NCKAP1L 3071 16 11 69

Total number of gains: 55; Total number of losses: 23; Total Number of normals: 410.  

 

Somatic mutations of NCKAP1L:

 

Generating mutation plots.

 

Highly correlated genes for NCKAP1L:

 

Showing top 20/627 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NCKAP1LTAGAP0.835874505
NCKAP1LSNX200.819186605
NCKAP1LGIMAP50.811269404
NCKAP1LCD163L10.802642303
NCKAP1LC19orf380.787558303
NCKAP1LIRF80.78626210010
NCKAP1LPIK3CG0.782256707
NCKAP1LTNFSF80.777886606
NCKAP1LBIN20.771114908
NCKAP1LCD530.770864807
NCKAP1LTNFRSF1B0.7690410010
NCKAP1LC16orf540.768243505
NCKAP1LTNFAIP8L20.768058605
NCKAP1LSLA0.76650210010
NCKAP1LPLCB20.765761707
NCKAP1LSASH30.7585171009
NCKAP1LPARVG0.754991706
NCKAP1LNOA10.753029303
NCKAP1LARHGAP90.752058706
NCKAP1LITGB20.7490921009

For details and further investigation, click here