| Full name: GRB2 related adaptor protein like | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 400581 | HGNC ID: HGNC:37240 | Ensembl Gene: ENSG00000189152 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of GRAPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRAPL | 400581 | 239074_at | 0.1683 | 0.5263 | |
| GSE26886 | GRAPL | 400581 | 239074_at | -0.3110 | 0.0188 | |
| GSE45670 | GRAPL | 400581 | 239074_at | 0.2171 | 0.0507 | |
| GSE63941 | GRAPL | 400581 | 239074_at | 0.0662 | 0.7413 | |
| GSE77861 | GRAPL | 400581 | 1560524_at | -0.0831 | 0.4731 | |
| GSE97050 | GRAPL | 400581 | A_24_P299355 | 0.5684 | 0.1939 | |
| SRP133303 | GRAPL | 400581 | RNAseq | -0.6676 | 0.0524 | |
| TCGA | GRAPL | 400581 | RNAseq | -0.7653 | 0.3300 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRAPL expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GRAPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRAPL | 400581 | 4 | 3 | 23 | |
| GSE20123 | GRAPL | 400581 | 4 | 4 | 22 | |
| GSE43470 | GRAPL | 400581 | 1 | 5 | 37 | |
| GSE46452 | GRAPL | 400581 | 34 | 1 | 24 | |
| GSE47630 | GRAPL | 400581 | 7 | 1 | 32 | |
| GSE54993 | GRAPL | 400581 | 3 | 3 | 64 | |
| GSE54994 | GRAPL | 400581 | 6 | 6 | 41 | |
| GSE60625 | GRAPL | 400581 | 4 | 0 | 7 | |
| GSE74703 | GRAPL | 400581 | 1 | 2 | 33 | |
| GSE74704 | GRAPL | 400581 | 3 | 1 | 16 | |
| TCGA | GRAPL | 400581 | 19 | 24 | 53 |
Total number of gains: 86; Total number of losses: 50; Total Number of normals: 352.
Somatic mutations of GRAPL:
Generating mutation plots.
Highly correlated genes for GRAPL:
Showing top 20/59 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRAPL | SNX20 | 0.81744 | 3 | 0 | 3 |
| GRAPL | IL18BP | 0.801475 | 3 | 0 | 3 |
| GRAPL | SMAP2 | 0.780274 | 3 | 0 | 3 |
| GRAPL | VASH1 | 0.764976 | 3 | 0 | 3 |
| GRAPL | ITGB2 | 0.758586 | 3 | 0 | 3 |
| GRAPL | MTHFD1L | 0.758454 | 3 | 0 | 3 |
| GRAPL | EVI2B | 0.745816 | 3 | 0 | 3 |
| GRAPL | BIN2 | 0.741262 | 4 | 0 | 3 |
| GRAPL | CCDC7 | 0.732959 | 3 | 0 | 3 |
| GRAPL | CHIC2 | 0.728213 | 3 | 0 | 3 |
| GRAPL | UBE2W | 0.725195 | 3 | 0 | 3 |
| GRAPL | MBTPS1 | 0.718234 | 3 | 0 | 3 |
| GRAPL | TNFAIP8L2 | 0.71774 | 3 | 0 | 3 |
| GRAPL | RBP5 | 0.707319 | 3 | 0 | 3 |
| GRAPL | ARPC4 | 0.705881 | 3 | 0 | 3 |
| GRAPL | PPP2R2A | 0.69994 | 3 | 0 | 3 |
| GRAPL | LPXN | 0.696805 | 3 | 0 | 3 |
| GRAPL | CD3E | 0.681959 | 4 | 0 | 3 |
| GRAPL | SCML4 | 0.674132 | 4 | 0 | 3 |
| GRAPL | RAB2A | 0.671531 | 3 | 0 | 3 |
For details and further investigation, click here
