| Full name: biogenesis of lysosomal organelles complex 1 subunit 3 | Alias Symbol: BLOS3|HPS8 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 388552 | HGNC ID: HGNC:20914 | Ensembl Gene: ENSG00000189114 | OMIM ID: 609762 |
| Drug and gene relationship at DGIdb | |||
Expression of BLOC1S3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BLOC1S3 | 388552 | 228244_at | 0.7969 | 0.0250 | |
| GSE26886 | BLOC1S3 | 388552 | 228244_at | 0.3825 | 0.0114 | |
| GSE45670 | BLOC1S3 | 388552 | 228244_at | 0.4994 | 0.0006 | |
| GSE53622 | BLOC1S3 | 388552 | 120680 | 0.3566 | 0.0000 | |
| GSE53624 | BLOC1S3 | 388552 | 120680 | 0.5607 | 0.0000 | |
| GSE63941 | BLOC1S3 | 388552 | 228244_at | -0.3019 | 0.3027 | |
| GSE77861 | BLOC1S3 | 388552 | 230576_at | -0.0273 | 0.8433 | |
| GSE97050 | BLOC1S3 | 388552 | A_33_P3329592 | -0.0653 | 0.9062 | |
| SRP007169 | BLOC1S3 | 388552 | RNAseq | 0.9226 | 0.1648 | |
| SRP008496 | BLOC1S3 | 388552 | RNAseq | 1.2901 | 0.0100 | |
| SRP064894 | BLOC1S3 | 388552 | RNAseq | 0.9754 | 0.0000 | |
| SRP133303 | BLOC1S3 | 388552 | RNAseq | 0.6395 | 0.0000 | |
| SRP159526 | BLOC1S3 | 388552 | RNAseq | 0.8330 | 0.0024 | |
| SRP193095 | BLOC1S3 | 388552 | RNAseq | 0.1925 | 0.0558 | |
| SRP219564 | BLOC1S3 | 388552 | RNAseq | 1.0605 | 0.0003 | |
| TCGA | BLOC1S3 | 388552 | RNAseq | 0.1728 | 0.0074 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by BLOC1S3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BLOC1S3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BLOC1S3 | 388552 | 4 | 5 | 21 | |
| GSE20123 | BLOC1S3 | 388552 | 4 | 4 | 22 | |
| GSE43470 | BLOC1S3 | 388552 | 3 | 11 | 29 | |
| GSE46452 | BLOC1S3 | 388552 | 45 | 1 | 13 | |
| GSE47630 | BLOC1S3 | 388552 | 8 | 6 | 26 | |
| GSE54993 | BLOC1S3 | 388552 | 17 | 4 | 49 | |
| GSE54994 | BLOC1S3 | 388552 | 6 | 12 | 35 | |
| GSE60625 | BLOC1S3 | 388552 | 9 | 0 | 2 | |
| GSE74703 | BLOC1S3 | 388552 | 3 | 7 | 26 | |
| GSE74704 | BLOC1S3 | 388552 | 4 | 2 | 14 | |
| TCGA | BLOC1S3 | 388552 | 14 | 17 | 65 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of BLOC1S3:
Generating mutation plots.
Highly correlated genes for BLOC1S3:
Showing top 20/335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BLOC1S3 | MRPS17 | 0.74169 | 3 | 0 | 3 |
| BLOC1S3 | PODXL2 | 0.737831 | 3 | 0 | 3 |
| BLOC1S3 | TCF15 | 0.730324 | 3 | 0 | 3 |
| BLOC1S3 | ARFRP1 | 0.721535 | 3 | 0 | 3 |
| BLOC1S3 | MTERF3 | 0.717935 | 3 | 0 | 3 |
| BLOC1S3 | IFRD2 | 0.712766 | 3 | 0 | 3 |
| BLOC1S3 | TIGD5 | 0.68962 | 3 | 0 | 3 |
| BLOC1S3 | GAS6-AS1 | 0.684396 | 3 | 0 | 3 |
| BLOC1S3 | TFDP2 | 0.68133 | 3 | 0 | 3 |
| BLOC1S3 | NEBL-AS1 | 0.679798 | 3 | 0 | 3 |
| BLOC1S3 | MEX3D | 0.679248 | 4 | 0 | 4 |
| BLOC1S3 | TMEM132A | 0.678641 | 3 | 0 | 3 |
| BLOC1S3 | ZFAT | 0.670043 | 3 | 0 | 3 |
| BLOC1S3 | CBS | 0.663674 | 4 | 0 | 3 |
| BLOC1S3 | IRF3 | 0.663424 | 4 | 0 | 4 |
| BLOC1S3 | NME3 | 0.659086 | 3 | 0 | 3 |
| BLOC1S3 | TMEM104 | 0.657858 | 5 | 0 | 5 |
| BLOC1S3 | LIMK1 | 0.651093 | 5 | 0 | 4 |
| BLOC1S3 | EMC10 | 0.651038 | 3 | 0 | 3 |
| BLOC1S3 | ZNF628 | 0.648255 | 4 | 0 | 4 |
For details and further investigation, click here
