IRF3

 

Full name: interferon regulatory factor 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 19q13.33
Entrez ID: 3661 HGNC ID: HGNC:6118 Ensembl Gene: ENSG00000126456 OMIM ID: 603734
Drug and gene relationship at DGIdb

 

IRF3 involved pathways:

KEGG pathway Description View
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05133Pertussis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection

 

Expression of IRF3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRF3 3661 202621_at 0.6662 0.1416
GSE20347 IRF3 3661 202621_at 0.3940 0.0014
GSE23400 IRF3 3661 202621_at 0.3462 0.0000
GSE26886 IRF3 3661 202621_at 0.1860 0.3191
GSE29001 IRF3 3661 202621_at 0.2768 0.2559
GSE38129 IRF3 3661 202621_at 0.4289 0.0004
GSE45670 IRF3 3661 202621_at 0.2706 0.0319
GSE53622 IRF3 3661 140972 0.4142 0.0000
GSE53624 IRF3 3661 140972 0.3813 0.0000
GSE63941 IRF3 3661 202621_at 2.1585 0.0000
GSE77861 IRF3 3661 202621_at 0.5001 0.0055
GSE97050 IRF3 3661 A_23_P27677 0.3107 0.2286
SRP007169 IRF3 3661 RNAseq -0.0129 0.9729
SRP008496 IRF3 3661 RNAseq 0.1488 0.6079
SRP064894 IRF3 3661 RNAseq 0.8811 0.0015
SRP133303 IRF3 3661 RNAseq 0.2505 0.1948
SRP159526 IRF3 3661 RNAseq 0.3610 0.0207
SRP193095 IRF3 3661 RNAseq 0.5480 0.0000
SRP219564 IRF3 3661 RNAseq 0.2469 0.3218
TCGA IRF3 3661 RNAseq 0.1182 0.0282

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by IRF3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IRF3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IRF3 3661 4 4 22
GSE20123 IRF3 3661 4 3 23
GSE43470 IRF3 3661 5 11 27
GSE46452 IRF3 3661 45 1 13
GSE47630 IRF3 3661 10 6 24
GSE54993 IRF3 3661 17 4 49
GSE54994 IRF3 3661 4 14 35
GSE60625 IRF3 3661 9 0 2
GSE74703 IRF3 3661 5 7 24
GSE74704 IRF3 3661 4 1 15
TCGA IRF3 3661 14 18 64

Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.  

 

Somatic mutations of IRF3:

 

Generating mutation plots.

 

Highly correlated genes for IRF3:

 

Showing top 20/469 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRF3LEP0.758701303
IRF3PANX20.731909303
IRF3CNOT30.692601706
IRF3PRR150.686534303
IRF3COA60.681676404
IRF3NPW0.679788303
IRF3BLOC1S30.663424404
IRF3COL7A10.65653511010
IRF3GTF3C50.649749504
IRF3LRWD10.647608303
IRF3UCN20.647478403
IRF3JPH10.642637403
IRF3FUT10.641146605
IRF3EGR40.639734303
IRF3EXOSC10.639598303
IRF3PRPF310.63906112011
IRF3TMEM2590.638487403
IRF3DHX340.6367712010
IRF3LINC010000.635667303
IRF3SOGA10.634317303

For details and further investigation, click here