| Full name: mitochondrial ribosomal protein S17 | Alias Symbol: HSPC011|RPMS17|MRP-S17 | ||
| Type: protein-coding gene | Cytoband: 7p11.2 | ||
| Entrez ID: 51373 | HGNC ID: HGNC:14047 | Ensembl Gene: ENSG00000239789 | OMIM ID: 611980 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPS17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS17 | 51373 | 218982_s_at | 1.3030 | 0.0248 | |
| GSE20347 | MRPS17 | 51373 | 218982_s_at | 1.1745 | 0.0007 | |
| GSE23400 | MRPS17 | 51373 | 218982_s_at | 1.1375 | 0.0000 | |
| GSE26886 | MRPS17 | 51373 | 218982_s_at | 1.3649 | 0.0000 | |
| GSE29001 | MRPS17 | 51373 | 218982_s_at | 0.8972 | 0.0065 | |
| GSE38129 | MRPS17 | 51373 | 218982_s_at | 1.2673 | 0.0000 | |
| GSE45670 | MRPS17 | 51373 | 218982_s_at | 1.0342 | 0.0000 | |
| GSE63941 | MRPS17 | 51373 | 218982_s_at | 1.5420 | 0.0100 | |
| GSE77861 | MRPS17 | 51373 | 218982_s_at | 0.6360 | 0.1064 | |
| GSE97050 | MRPS17 | 51373 | A_23_P258321 | 0.4238 | 0.2272 | |
| SRP007169 | MRPS17 | 51373 | RNAseq | 1.0610 | 0.0175 | |
| SRP008496 | MRPS17 | 51373 | RNAseq | 1.2068 | 0.0037 | |
| SRP064894 | MRPS17 | 51373 | RNAseq | 0.8767 | 0.0027 | |
| SRP133303 | MRPS17 | 51373 | RNAseq | 0.6195 | 0.0001 | |
| SRP159526 | MRPS17 | 51373 | RNAseq | 0.8771 | 0.0094 | |
| SRP193095 | MRPS17 | 51373 | RNAseq | 0.4511 | 0.0013 | |
| SRP219564 | MRPS17 | 51373 | RNAseq | 0.3773 | 0.3291 | |
| TCGA | MRPS17 | 51373 | RNAseq | 0.3533 | 0.0003 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by MRPS17 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPS17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS17 | 51373 | 13 | 0 | 17 | |
| GSE20123 | MRPS17 | 51373 | 11 | 0 | 19 | |
| GSE43470 | MRPS17 | 51373 | 5 | 0 | 38 | |
| GSE46452 | MRPS17 | 51373 | 13 | 0 | 46 | |
| GSE47630 | MRPS17 | 51373 | 10 | 1 | 29 | |
| GSE54993 | MRPS17 | 51373 | 0 | 8 | 62 | |
| GSE54994 | MRPS17 | 51373 | 16 | 2 | 35 | |
| GSE60625 | MRPS17 | 51373 | 0 | 0 | 11 | |
| GSE74703 | MRPS17 | 51373 | 5 | 0 | 31 | |
| GSE74704 | MRPS17 | 51373 | 6 | 0 | 14 | |
| TCGA | MRPS17 | 51373 | 54 | 6 | 36 |
Total number of gains: 133; Total number of losses: 17; Total Number of normals: 338.
Somatic mutations of MRPS17:
Generating mutation plots.
Highly correlated genes for MRPS17:
Showing top 20/1347 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS17 | CCT6A | 0.820935 | 9 | 0 | 9 |
| MRPS17 | SFR1 | 0.816114 | 3 | 0 | 3 |
| MRPS17 | DHX37 | 0.814311 | 3 | 0 | 3 |
| MRPS17 | NTMT1 | 0.796192 | 3 | 0 | 3 |
| MRPS17 | RRP15 | 0.756413 | 8 | 0 | 8 |
| MRPS17 | WDR66 | 0.75173 | 5 | 0 | 5 |
| MRPS17 | BOLA3 | 0.749552 | 4 | 0 | 4 |
| MRPS17 | SLC25A32 | 0.748115 | 8 | 0 | 8 |
| MRPS17 | MPLKIP | 0.745778 | 5 | 0 | 4 |
| MRPS17 | POLR1A | 0.744381 | 4 | 0 | 4 |
| MRPS17 | CMSS1 | 0.742773 | 5 | 0 | 5 |
| MRPS17 | BLOC1S3 | 0.74169 | 3 | 0 | 3 |
| MRPS17 | CCDC86 | 0.74156 | 8 | 0 | 7 |
| MRPS17 | CBX3 | 0.738601 | 9 | 0 | 9 |
| MRPS17 | GNPNAT1 | 0.737436 | 4 | 0 | 4 |
| MRPS17 | CHCHD2 | 0.736339 | 10 | 0 | 9 |
| MRPS17 | CCM2 | 0.73623 | 4 | 0 | 3 |
| MRPS17 | PSMB2 | 0.730845 | 8 | 0 | 8 |
| MRPS17 | WDR53 | 0.728238 | 5 | 0 | 4 |
| MRPS17 | UBE2C | 0.725128 | 9 | 0 | 8 |
For details and further investigation, click here
