| Full name: cystathionine beta-synthase | Alias Symbol: HIP4 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 875 | HGNC ID: HGNC:1550 | Ensembl Gene: ENSG00000160200 | OMIM ID: 613381 |
| Drug and gene relationship at DGIdb | |||
Expression of CBS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBS | 875 | 1553972_a_at | 1.3338 | 0.0548 | |
| GSE20347 | CBS | 875 | 212816_s_at | 1.4454 | 0.0000 | |
| GSE23400 | CBS | 875 | 212816_s_at | 0.4292 | 0.0000 | |
| GSE26886 | CBS | 875 | 240517_at | 0.4802 | 0.0009 | |
| GSE29001 | CBS | 875 | 212816_s_at | 1.2147 | 0.0001 | |
| GSE38129 | CBS | 875 | 212816_s_at | 1.4104 | 0.0000 | |
| GSE45670 | CBS | 875 | 1553972_a_at | 0.7123 | 0.0062 | |
| GSE63941 | CBS | 875 | 1553972_a_at | 0.5120 | 0.6797 | |
| GSE77861 | CBS | 875 | 240517_at | -0.0387 | 0.8064 | |
| GSE97050 | CBS | 875 | A_23_P166306 | 0.3037 | 0.2987 | |
| SRP007169 | CBS | 875 | RNAseq | 6.8721 | 0.0000 | |
| SRP008496 | CBS | 875 | RNAseq | 7.1452 | 0.0000 | |
| SRP133303 | CBS | 875 | RNAseq | 1.7290 | 0.0003 | |
| SRP159526 | CBS | 875 | RNAseq | 3.7326 | 0.0003 | |
| SRP219564 | CBS | 875 | RNAseq | 2.4785 | 0.0003 | |
| TCGA | CBS | 875 | RNAseq | -0.0680 | 0.7140 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by CBS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CBS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBS | 875 | 2 | 8 | 20 | |
| GSE20123 | CBS | 875 | 2 | 8 | 20 | |
| GSE43470 | CBS | 875 | 0 | 13 | 30 | |
| GSE46452 | CBS | 875 | 1 | 21 | 37 | |
| GSE47630 | CBS | 875 | 6 | 17 | 17 | |
| GSE54993 | CBS | 875 | 8 | 1 | 61 | |
| GSE54994 | CBS | 875 | 4 | 8 | 41 | |
| GSE60625 | CBS | 875 | 0 | 0 | 11 | |
| GSE74703 | CBS | 875 | 0 | 10 | 26 | |
| GSE74704 | CBS | 875 | 1 | 4 | 15 | |
| TCGA | CBS | 875 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of CBS:
Generating mutation plots.
Highly correlated genes for CBS:
Showing top 20/597 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBS | TFR2 | 0.814812 | 3 | 0 | 3 |
| CBS | GAS6-AS1 | 0.762722 | 3 | 0 | 3 |
| CBS | FAM53A | 0.761842 | 3 | 0 | 3 |
| CBS | FBXO44 | 0.759019 | 3 | 0 | 3 |
| CBS | C21orf58 | 0.745609 | 3 | 0 | 3 |
| CBS | ZNF574 | 0.742508 | 3 | 0 | 3 |
| CBS | CHTF18 | 0.732767 | 3 | 0 | 3 |
| CBS | GPC2 | 0.724214 | 3 | 0 | 3 |
| CBS | HDAC7 | 0.716899 | 3 | 0 | 3 |
| CBS | TNK2 | 0.71659 | 3 | 0 | 3 |
| CBS | PLD4 | 0.714214 | 3 | 0 | 3 |
| CBS | AP2A1 | 0.707513 | 3 | 0 | 3 |
| CBS | DLG4 | 0.695908 | 3 | 0 | 3 |
| CBS | ZNF316 | 0.692555 | 3 | 0 | 3 |
| CBS | ASB6 | 0.691568 | 4 | 0 | 4 |
| CBS | DOHH | 0.69006 | 4 | 0 | 4 |
| CBS | MBD6 | 0.676484 | 3 | 0 | 3 |
| CBS | SLC39A3 | 0.675147 | 4 | 0 | 4 |
| CBS | PTDSS1 | 0.672541 | 6 | 0 | 6 |
| CBS | CDH4 | 0.672383 | 3 | 0 | 3 |
For details and further investigation, click here
