BRD7

 

Full name: bromodomain containing 7 Alias Symbol: CELTIX1|BP75
Type: protein-coding gene Cytoband: 16q12.1
Entrez ID: 29117 HGNC ID: HGNC:14310 Ensembl Gene: ENSG00000166164 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 54/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of BRD7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BRD7 29117 222737_s_at -0.1720 0.7346
GSE20347 BRD7 29117 221776_s_at -0.1305 0.4300
GSE23400 BRD7 29117 221776_s_at 0.0705 0.4520
GSE26886 BRD7 29117 221776_s_at -0.4382 0.0559
GSE29001 BRD7 29117 221776_s_at -0.2593 0.5869
GSE38129 BRD7 29117 221776_s_at 0.0414 0.7600
GSE45670 BRD7 29117 222737_s_at 0.0317 0.7847
GSE63941 BRD7 29117 221776_s_at 0.0113 0.9735
GSE77861 BRD7 29117 221776_s_at 0.2749 0.1998
GSE97050 BRD7 29117 A_32_P18824 -0.1709 0.3640
SRP007169 BRD7 29117 RNAseq -0.0089 0.9791
SRP008496 BRD7 29117 RNAseq 0.0839 0.7383
SRP064894 BRD7 29117 RNAseq -0.3702 0.0023
SRP133303 BRD7 29117 RNAseq -0.0370 0.7468
SRP159526 BRD7 29117 RNAseq -0.0417 0.8565
SRP193095 BRD7 29117 RNAseq -0.2087 0.0527
SRP219564 BRD7 29117 RNAseq -0.3229 0.2646
TCGA BRD7 29117 RNAseq 0.0616 0.2032

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by BRD7 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of BRD7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BRD7 29117 3 1 26
GSE20123 BRD7 29117 3 1 26
GSE43470 BRD7 29117 2 7 34
GSE46452 BRD7 29117 38 1 20
GSE47630 BRD7 29117 11 7 22
GSE54993 BRD7 29117 2 5 63
GSE54994 BRD7 29117 6 10 37
GSE60625 BRD7 29117 4 0 7
GSE74703 BRD7 29117 2 4 30
GSE74704 BRD7 29117 3 1 16
TCGA BRD7 29117 25 12 59

Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.  

 

Somatic mutations of BRD7:

 

Generating mutation plots.

 

Highly correlated genes for BRD7:

 

Showing top 20/125 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BRD7COPS30.69571303
BRD7GLUD10.682125303
BRD7PPP2R5E0.661004403
BRD7VAMP70.659862404
BRD7NSFL1C0.659104404
BRD7PSMB70.655127505
BRD7STX180.653461403
BRD7YTHDF20.650907303
BRD7UPF20.647703303
BRD7PSMD90.644345404
BRD7BUD130.642398303
BRD7COMMD90.635216303
BRD7HSPA90.633623403
BRD7HNRNPUL20.630632303
BRD7IMPACT0.630179303
BRD7PRMT50.628749404
BRD7ALYREF0.6273303
BRD7XRCC60.625131604
BRD7RAN0.620771404
BRD7MRPS70.613958504

For details and further investigation, click here