| Full name: COP9 signalosome subunit 3 | Alias Symbol: SGN3|CSN3 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 8533 | HGNC ID: HGNC:2239 | Ensembl Gene: ENSG00000141030 | OMIM ID: 604665 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COPS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS3 | 8533 | 202078_at | 0.0726 | 0.8117 | |
| GSE20347 | COPS3 | 8533 | 202078_at | -0.0200 | 0.9230 | |
| GSE23400 | COPS3 | 8533 | 202078_at | 0.2785 | 0.0001 | |
| GSE26886 | COPS3 | 8533 | 202078_at | -0.0932 | 0.7127 | |
| GSE29001 | COPS3 | 8533 | 202078_at | 0.1215 | 0.7757 | |
| GSE38129 | COPS3 | 8533 | 202078_at | 0.1666 | 0.2506 | |
| GSE45670 | COPS3 | 8533 | 202078_at | 0.1062 | 0.4298 | |
| GSE53622 | COPS3 | 8533 | 80044 | 0.0952 | 0.2657 | |
| GSE53624 | COPS3 | 8533 | 80044 | 0.3206 | 0.0000 | |
| GSE63941 | COPS3 | 8533 | 202078_at | 0.6347 | 0.2511 | |
| GSE77861 | COPS3 | 8533 | 202078_at | 0.0028 | 0.9908 | |
| GSE97050 | COPS3 | 8533 | A_23_P89199 | 0.2632 | 0.3496 | |
| SRP007169 | COPS3 | 8533 | RNAseq | -0.0138 | 0.9709 | |
| SRP008496 | COPS3 | 8533 | RNAseq | -0.0038 | 0.9844 | |
| SRP064894 | COPS3 | 8533 | RNAseq | 0.4935 | 0.0219 | |
| SRP133303 | COPS3 | 8533 | RNAseq | 0.3316 | 0.0216 | |
| SRP159526 | COPS3 | 8533 | RNAseq | 0.0036 | 0.9832 | |
| SRP193095 | COPS3 | 8533 | RNAseq | -0.1386 | 0.3517 | |
| SRP219564 | COPS3 | 8533 | RNAseq | 0.2689 | 0.4245 | |
| TCGA | COPS3 | 8533 | RNAseq | 0.0951 | 0.0476 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COPS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS3 | 8533 | 3 | 3 | 24 | |
| GSE20123 | COPS3 | 8533 | 3 | 4 | 23 | |
| GSE43470 | COPS3 | 8533 | 2 | 5 | 36 | |
| GSE46452 | COPS3 | 8533 | 34 | 1 | 24 | |
| GSE47630 | COPS3 | 8533 | 7 | 1 | 32 | |
| GSE54993 | COPS3 | 8533 | 3 | 3 | 64 | |
| GSE54994 | COPS3 | 8533 | 6 | 5 | 42 | |
| GSE60625 | COPS3 | 8533 | 4 | 0 | 7 | |
| GSE74703 | COPS3 | 8533 | 2 | 2 | 32 | |
| GSE74704 | COPS3 | 8533 | 2 | 1 | 17 | |
| TCGA | COPS3 | 8533 | 18 | 23 | 55 |
Total number of gains: 84; Total number of losses: 48; Total Number of normals: 356.
Somatic mutations of COPS3:
Generating mutation plots.
Highly correlated genes for COPS3:
Showing top 20/592 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS3 | DSE | 0.739066 | 3 | 0 | 3 |
| COPS3 | INTS12 | 0.725547 | 4 | 0 | 4 |
| COPS3 | HYLS1 | 0.722107 | 3 | 0 | 3 |
| COPS3 | RPS27 | 0.71635 | 3 | 0 | 3 |
| COPS3 | KLHL18 | 0.71456 | 3 | 0 | 3 |
| COPS3 | PARG | 0.714165 | 3 | 0 | 3 |
| COPS3 | RCHY1 | 0.706706 | 3 | 0 | 3 |
| COPS3 | PDE8A | 0.700438 | 4 | 0 | 3 |
| COPS3 | PPWD1 | 0.695742 | 4 | 0 | 4 |
| COPS3 | BRD7 | 0.69571 | 3 | 0 | 3 |
| COPS3 | CYB5A | 0.69008 | 3 | 0 | 3 |
| COPS3 | ANKRD28 | 0.684633 | 3 | 0 | 3 |
| COPS3 | NEK7 | 0.683579 | 3 | 0 | 3 |
| COPS3 | CHD1 | 0.679713 | 4 | 0 | 3 |
| COPS3 | CCNC | 0.679475 | 5 | 0 | 4 |
| COPS3 | C1QBP | 0.677307 | 11 | 0 | 9 |
| COPS3 | RRP36 | 0.675355 | 6 | 0 | 6 |
| COPS3 | ZNF628 | 0.672884 | 3 | 0 | 3 |
| COPS3 | TRAPPC1 | 0.672085 | 3 | 0 | 3 |
| COPS3 | CRK | 0.671983 | 5 | 0 | 3 |
For details and further investigation, click here
